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GENE CARD

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Gene Card

Best human hits

C3; C4B; C5

Species

H.roretzi

Unique Gene ID

Harore.g00008540

Gene Model ID

Harore.CG.MTP2014.S56.g08540

Location

S56:331362..344938

Transcript Models and Sequences

  Harore.CG.MTP2014.S56.g08540.01.t

External Database Gene Card

External database links

No result

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WashU Genome Browser

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Genomicus Synteny Browser

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Regulatory Regions

Regulatory Regions

No result

n/a

Gene Phylogeny

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Gene Annotations

InterPro

17 results

IPR Term Analysis Definition
Ig-like_fold Gene3D Immunoglobulin-like fold
Netrin_module_non-TIMP Pfam Netrin module, non-TIMP type
Macroglobln_a2 Pfam Alpha-2-macroglobulin
Macroglobln_a2 SMART Alpha-2-macroglobulin
A-macroglobulin_rcpt-bd SMART Alpha-macroglobulin, receptor-binding
MacrogloblnA2_thiol-ester-bond Pfam Alpha-2-macroglobulin, thiol-ester bond-forming
Terpenoid_cyclase/PrenylTrfase SUPERFAMILY Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
TIMP-like_OB-fold SUPERFAMILY Tissue inhibitor of metalloproteinases-like, OB-fold
A-macroglobulin_rcpt-bd_sf SUPERFAMILY Alpha-macroglobulin, receptor-binding domain superfamily
A2M_comp Pfam Alpha-macroglobulin complement component
A-macroglobulin_rcpt-bd Pfam Alpha-macroglobulin, receptor-binding
A2M_N_2 Pfam Alpha-2-macroglobulin, N-terminal 2
Netrin_domain ProSiteProfiles Netrin domain
A-macroglobulin_rcpt-bd_sf Gene3D Alpha-macroglobulin, receptor-binding domain superfamily
A2M_N_2 SMART Alpha-2-macroglobulin, N-terminal 2
A2M_N Pfam Alpha-2-macroglobulin, N-terminal
MacrogloblnA2_CS ProSitePatterns Alpha-2-macroglobulin, conserved site

GOSlim

51 results

GO Term Annotation Origin Type
immune system process Orthology biological process
serine-type endopeptidase activity Orthology molecular function
receptor binding Orthology molecular function
protein binding Orthology molecular function
extracellular region Orthology cellular component
extracellular space Orthology cellular component
endoplasmic reticulum lumen Orthology cellular component
plasma membrane Orthology cellular component
proteolysis Orthology biological process
chemotaxis Orthology biological process
immune response Orthology biological process
signal transduction Orthology biological process
cell surface receptor signaling pathway Orthology biological process
G-protein coupled receptor signaling pathway Orthology biological process
cell junction Orthology cellular component
axon Orthology cellular component
macromolecular complex Orthology cellular component
cell projection Orthology cellular component
innate immune response Orthology biological process
synapse Orthology cellular component
extracellular exosome Orthology cellular component
neuronal cell body Orthology cellular component
positive regulation of catalytic activity Orthology biological process
intracellular signal transduction Orthology biological process
protein serine/threonine kinase activity Orthology molecular function
positive regulation of signal transduction Orthology biological process
protein phosphorylation Orthology biological process
endopeptidase activity Orthology molecular function
enzyme regulator activity Orthology molecular function
enzyme binding Orthology molecular function
integral component of plasma membrane Orthology cellular component
organic substance metabolic process Orthology biological process
cellular metabolic process Orthology biological process
membrane organization Orthology biological process
organelle organization Orthology biological process
defense response Orthology biological process
protein metabolic process Orthology biological process
cell migration Orthology biological process
molecular function regulator Orthology molecular function
signaling receptor activity Orthology molecular function
regulation of signal transduction Orthology biological process
cellular process Orthology biological process
binding Orthology molecular function
intracellular organelle part Orthology cellular component
cytoplasmic vesicle Orthology cellular component
endomembrane system Orthology cellular component
intracellular organelle lumen Orthology cellular component
lysosome Orthology cellular component
vacuolar part Orthology cellular component
cellular protein modification process Orthology biological process
angiogenesis Orthology biological process

GO (Orthology)

54 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type
activation of MAPK activity Hs biological process
complement binding Hs molecular function
positive regulation of protein phosphorylation Hs biological process
immune system process Hs biological process
serine-type endopeptidase activity Hs molecular function
endopeptidase inhibitor activity Hs molecular function
receptor binding Hs molecular function
protein binding Hs molecular function
extracellular region Hs cellular component
membrane attack complex Hs cellular component
extracellular space Hs cellular component
endoplasmic reticulum lumen Hs cellular component
plasma membrane Hs cellular component
proteolysis Hs biological process
lipid metabolic process Hs biological process
fatty acid metabolic process Hs biological process
phagocytosis, engulfment Hs biological process
chemotaxis Hs biological process
inflammatory response Hs biological process
immune response Hs biological process
complement activation Hs biological process
complement activation, alternative pathway Hs biological process
complement activation, classical pathway Hs biological process
signal transduction Hs biological process
cell surface receptor signaling pathway Hs biological process
G-protein coupled receptor signaling pathway Hs biological process
chemokine activity Hs molecular function
positive regulation of vascular endothelial growth factor production Hs biological process
regulation of triglyceride biosynthetic process Hs biological process
positive regulation of lipid storage Hs biological process
negative regulation of endopeptidase activity Hs biological process
cytolysis Hs biological process
cell junction Hs cellular component
carbohydrate binding Hs molecular function
axon Hs cellular component
dendrite Hs cellular component
C5L2 anaphylatoxin chemotactic receptor binding Hs molecular function
macromolecular complex Hs cellular component
secretory granule lumen Hs cellular component
azurophil granule lumen Hs cellular component
cell projection Hs cellular component
post-translational protein modification Hs biological process
other organism cell Hs cellular component
innate immune response Hs biological process
synapse Hs cellular component
positive regulation of G-protein coupled receptor protein signaling pathway Hs biological process
positive regulation of angiogenesis Hs biological process
positive regulation of phagocytosis Hs biological process
regulation of immune response Hs biological process
cell chemotaxis Hs biological process
extracellular exosome Hs cellular component
blood microparticle Hs cellular component
complement component C1q binding Hs molecular function
neuronal cell body Hs cellular component

GO (Blast)

24 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type Score E-value
complement binding Hs molecular function 332 4.94e-92
serine-type endopeptidase activity Hs molecular function 413 2.02e-118
endopeptidase inhibitor activity Hs molecular function 413 2.02e-118
receptor binding Hs molecular function 413 2.02e-118
protein binding Hs molecular function 413 2.02e-118
extracellular region Hs cellular component 413 2.02e-118
membrane attack complex Hs cellular component 342 1.85e-95
extracellular space Hs cellular component 413 2.02e-118
endoplasmic reticulum lumen Hs cellular component 413 2.02e-118
plasma membrane Hs cellular component 413 2.02e-118
chemokine activity Hs molecular function 342 1.85e-95
cell junction Hs cellular component 332 4.94e-92
carbohydrate binding Hs molecular function 332 4.94e-92
axon Hs cellular component 332 4.94e-92
dendrite Hs cellular component 332 4.94e-92
C5L2 anaphylatoxin chemotactic receptor binding Hs molecular function 413 2.02e-118
macromolecular complex Hs cellular component 413 2.02e-118
secretory granule lumen Hs cellular component 413 2.02e-118
azurophil granule lumen Hs cellular component 413 2.02e-118
cell projection Hs cellular component 332 4.94e-92
other organism cell Hs cellular component 332 4.94e-92
synapse Hs cellular component 332 4.94e-92
extracellular exosome Hs cellular component 413 2.02e-118
blood microparticle Hs cellular component 413 2.02e-118

GO (InterProScan)

4 results

GO Term Analysis Type e-value
endopeptidase inhibitor activity SMART molecular function 9.0E-19
protein binding ProSiteProfiles molecular function 11.679
extracellular region Gene3D cellular component 8.8E-142
extracellular space Pfam cellular component 3.7E-66

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