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GENE CARD

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Gene Card

Best human hits

HDAC1; HDAC2; HDAC3

Species

H.roretzi

Unique Gene ID

Harore.g00002432

Gene Model ID

Harore.CG.MTP2014.S929.g02432

Location

S929:4480..8583

Transcript Models and Sequences

  Harore.CG.MTP2014.S929.g02432.01.t

External Database Gene Card

External database links

No result

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WashU Genome Browser

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Genomicus Synteny Browser

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Regulatory Regions

Regulatory Regions

No result

n/a

Gene Phylogeny

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Gene Annotations

InterPro

6 results

IPR Term Analysis Definition
Ureohydrolase_dom_sf SUPERFAMILY Ureohydrolase domain superfamily
His_deacetylse_1 PRINTS Histone deacetylase
His_deacetylse_dom_sf Gene3D Histone deacetylase domain superfamily
His_deacetylse_dom Pfam Histone deacetylase domain
His_deacetylse PRINTS Histone deacetylase superfamily
His_deacetylse PANTHER Histone deacetylase superfamily

GOSlim

66 results

GO Term Annotation Origin Type
negative regulation of transcription from RNA polymerase II promoter Orthology biological process
transcription regulatory region sequence-specific DNA binding Orthology molecular function
RNA polymerase II core promoter proximal region sequence-specific DNA binding Orthology molecular function
chromatin binding Orthology molecular function
transcription factor activity, sequence-specific DNA binding Orthology molecular function
transcription corepressor activity Blast molecular function
RNA binding Orthology molecular function
protein binding Orthology molecular function
nucleus Orthology cellular component
nucleoplasm Orthology cellular component
cytoplasm Orthology cellular component
Golgi apparatus Blast cellular component
cytosol Orthology cellular component
plasma membrane Blast cellular component
transcription, DNA-templated Orthology biological process
regulation of transcription, DNA-templated Orthology biological process
blood coagulation Orthology biological process
transcription factor binding Orthology molecular function
positive regulation of cell proliferation Orthology biological process
negative regulation of gene expression Orthology biological process
membrane Orthology cellular component
integral component of membrane Orthology cellular component
hydrolase activity Orthology molecular function
enzyme binding Orthology molecular function
response to lipopolysaccharide Orthology biological process
macromolecular complex Orthology cellular component
negative regulation of apoptotic process Orthology biological process
sequence-specific DNA binding Orthology molecular function
transcription regulatory region DNA binding Orthology molecular function
negative regulation of transcription, DNA-templated Orthology biological process
positive regulation of transcription, DNA-templated Orthology biological process
positive regulation of transcription from RNA polymerase II promoter Orthology biological process
metal ion binding Orthology molecular function
protein N-terminus binding Orthology molecular function
negative regulation of canonical Wnt signaling pathway Orthology biological process
nucleoplasm part Orthology cellular component
intracellular organelle part Orthology cellular component
intracellular non-membrane-bounded organelle Orthology cellular component
nuclear lumen Orthology cellular component
RNA polymerase II regulatory region sequence-specific DNA binding Orthology molecular function
response to organic substance Orthology biological process
organelle organization Orthology biological process
cellular protein modification process Orthology biological process
DNA metabolic process Orthology biological process
anatomical structure development Orthology biological process
cell differentiation Orthology biological process
animal organ development Orthology biological process
neuron projection development Orthology biological process
macromolecular complex binding Orthology molecular function
DNA binding Orthology molecular function
regulation of gene expression Orthology biological process
cellular response to stress Orthology biological process
cell surface receptor signaling pathway Orthology biological process
positive regulation of signal transduction Orthology biological process
protein phosphorylation Orthology biological process
regulation of molecular function Orthology biological process
regulation of RNA biosynthetic process Orthology biological process
proteolysis Orthology biological process
cell development Orthology biological process
generation of neurons Orthology biological process
central nervous system development Orthology biological process
response to stress Orthology biological process
response to oxidative stress Orthology biological process
response to lipid Orthology biological process
cellular response to organic substance Orthology biological process
microtubule Blast cellular component

GO (Orthology)

88 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type
histone deacetylase complex Hs cellular component
negative regulation of transcription from RNA polymerase II promoter Hs biological process
chromatin Hs cellular component
nuclear chromatin Hs cellular component
transcription regulatory region sequence-specific DNA binding Hs molecular function
RNA polymerase II core promoter proximal region sequence-specific DNA binding Hs molecular function
RNA polymerase II distal enhancer sequence-specific DNA binding Hs molecular function
core promoter sequence-specific DNA binding Hs molecular function
core promoter binding Hs molecular function
RNA polymerase II transcription factor binding Hs molecular function
RNA polymerase II repressing transcription factor binding Hs molecular function
RNA polymerase II transcription corepressor activity Hs molecular function
response to amphetamine Hs biological process
p53 binding Hs molecular function
chromatin binding Hs molecular function
transcription factor activity, sequence-specific DNA binding Hs molecular function
RNA binding Hs molecular function
histone deacetylase activity Hs molecular function
protein binding Hs molecular function
nucleus Hs cellular component
nucleoplasm Hs cellular component
cytoplasm Hs cellular component
cytosol Hs cellular component
chromatin organization Hs biological process
chromatin remodeling Hs biological process
methylation-dependent chromatin silencing Hs biological process
transcription, DNA-templated Hs biological process
regulation of transcription, DNA-templated Hs biological process
protein deacetylation Hs biological process
blood coagulation Hs biological process
transcription factor binding Hs molecular function
positive regulation of cell proliferation Hs biological process
epidermal cell differentiation Hs biological process
negative regulation of gene expression Hs biological process
positive regulation of epithelial to mesenchymal transition Hs biological process
negative regulation of neuron projection development Hs biological process
membrane Hs cellular component
integral component of membrane Hs cellular component
viral process Hs biological process
dendrite development Hs biological process
histone deacetylation Hs biological process
Sin3 complex Hs cellular component
NuRD complex Hs cellular component
hydrolase activity Hs molecular function
deacetylase activity Hs molecular function
enzyme binding Hs molecular function
response to caffeine Hs biological process
heat shock protein binding Hs molecular function
nucleosomal DNA binding Hs molecular function
NAD-dependent histone deacetylase activity (H3-K14 specific) Hs molecular function
response to lipopolysaccharide Hs biological process
circadian regulation of gene expression Hs biological process
macromolecular complex Hs cellular component
protein deacetylase activity Hs molecular function
activating transcription factor binding Hs molecular function
cellular response to heat Hs biological process
response to nicotine Hs biological process
ESC/E(Z) complex Hs cellular component
response to cocaine Hs biological process
response to drug Hs biological process
positive regulation of tyrosine phosphorylation of STAT protein Hs biological process
histone deacetylase binding Hs molecular function
ATP-dependent chromatin remodeling Hs biological process
negative regulation of apoptotic process Hs biological process
negative regulation of DNA binding Hs biological process
negative regulation of sequence-specific DNA binding transcription factor activity Hs biological process
sequence-specific DNA binding Hs molecular function
negative regulation by host of viral transcription Hs biological process
transcription regulatory region DNA binding Hs molecular function
positive regulation of proteolysis Hs biological process
negative regulation of transcription, DNA-templated Hs biological process
positive regulation of transcription, DNA-templated Hs biological process
positive regulation of transcription from RNA polymerase II promoter Hs biological process
metal ion binding Hs molecular function
protein N-terminus binding Hs molecular function
behavioral response to ethanol Hs biological process
rhythmic process Hs biological process
positive regulation of oligodendrocyte differentiation Hs biological process
NF-kappaB binding Hs molecular function
response to hyperoxia Hs biological process
cellular response to hydrogen peroxide Hs biological process
repressing transcription factor binding Hs molecular function
histone H3 deacetylation Hs biological process
cellular response to retinoic acid Hs biological process
cellular response to transforming growth factor beta stimulus Hs biological process
negative regulation of canonical Wnt signaling pathway Hs biological process
cellular response to dopamine Hs biological process
promoter-specific chromatin binding Hs molecular function

GO (Blast)

50 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type Score E-value
histone deacetylase complex Hs cellular component 775 0.0
chromatin Hs cellular component 790 0.0
nuclear chromatin Hs cellular component 790 0.0
transcription regulatory region sequence-specific DNA binding Hs molecular function 775 0.0
RNA polymerase II core promoter proximal region sequence-specific DNA binding Hs molecular function 790 0.0
RNA polymerase II distal enhancer sequence-specific DNA binding Hs molecular function 790 0.0
core promoter sequence-specific DNA binding Hs molecular function 775 0.0
core promoter binding Hs molecular function 775 0.0
RNA polymerase II transcription factor binding Hs molecular function 775 0.0
RNA polymerase II repressing transcription factor binding Hs molecular function 790 0.0
RNA polymerase II transcription corepressor activity Hs molecular function 775 0.0
p53 binding Hs molecular function 775 0.0
chromatin binding Hs molecular function 790 0.0
transcription factor activity, sequence-specific DNA binding Hs molecular function 775 0.0
transcription corepressor activity Hs molecular function 558 0.0
RNA binding Hs molecular function 790 0.0
histone deacetylase activity Hs molecular function 790 0.0
protein binding Hs molecular function 790 0.0
nucleus Hs cellular component 790 0.0
nucleoplasm Hs cellular component 790 0.0
cytoplasm Hs cellular component 790 0.0
Golgi apparatus Hs cellular component 558 0.0
cytosol Hs cellular component 775 0.0
spindle microtubule Hs cellular component 558 0.0
plasma membrane Hs cellular component 558 0.0
transcription factor binding Hs molecular function 790 0.0
membrane Hs cellular component 790 0.0
integral component of membrane Hs cellular component 790 0.0
Sin3 complex Hs cellular component 790 0.0
NuRD complex Hs cellular component 790 0.0
hydrolase activity Hs molecular function 790 0.0
transcriptional repressor complex Hs cellular component 558 0.0
deacetylase activity Hs molecular function 790 0.0
enzyme binding Hs molecular function 790 0.0
cyclin binding Hs molecular function 558 0.0
heat shock protein binding Hs molecular function 790 0.0
nucleosomal DNA binding Hs molecular function 790 0.0
NAD-dependent histone deacetylase activity (H3-K14 specific) Hs molecular function 790 0.0
macromolecular complex Hs cellular component 790 0.0
protein deacetylase activity Hs molecular function 790 0.0
activating transcription factor binding Hs molecular function 775 0.0
ESC/E(Z) complex Hs cellular component 790 0.0
histone deacetylase binding Hs molecular function 790 0.0
sequence-specific DNA binding Hs molecular function 790 0.0
transcription regulatory region DNA binding Hs molecular function 775 0.0
metal ion binding Hs molecular function 775 0.0
protein N-terminus binding Hs molecular function 775 0.0
NF-kappaB binding Hs molecular function 790 0.0
repressing transcription factor binding Hs molecular function 775 0.0
promoter-specific chromatin binding Hs molecular function 790 0.0

GO (InterProScan)

2 results

GO Term Analysis Type e-value
histone deacetylase activity PRINTS molecular function 5.7E-71
histone deacetylation PRINTS biological process 5.7E-71

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