Gene Card
Best human hits
C3; C5; CD109
Unique Gene ID
Cirobu.g00000199
Gene Model ID
KH2012:KH.C1.1179
Location
KhC1:8335014..8362599
Transcript Models and Sequences
KH2012:KH.C1.1179.v1.A.ND1-1
KH2012:KH.C1.1179.v1.A.nonSL2-1
ciad011b22
Plate: R1CiGC02i03
ciad028a04
Plate: R1CiGC03f03
n/a
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You can Press 'Ctrl' Key + Left Mouse Click on nodes to do a multiple selection.

IPR Term | Analysis | Definition |
---|---|---|
MacrogloblnA2_CS | ProSitePatterns | Alpha-2-macroglobulin, conserved site |
A-macroglobulin_rcpt-bd | SMART | Alpha-macroglobulin, receptor-binding |
Netrin_domain | ProSiteProfiles | Netrin domain |
A2M_N_2 | Pfam | Alpha-2-macroglobulin, N-terminal 2 |
Macroglobln_a2 | SMART | Alpha-2-macroglobulin |
Macroglobln_a2 | Pfam | Alpha-2-macroglobulin |
Netrin_module_non-TIMP | Pfam | Netrin module, non-TIMP type |
A-macroglobulin_rcpt-bd | Pfam | Alpha-macroglobulin, receptor-binding |
Ig-like_fold | Gene3D | Immunoglobulin-like fold |
A2M_N_2 | SMART | Alpha-2-macroglobulin, N-terminal 2 |
A2M_comp | Pfam | Alpha-macroglobulin complement component |
TIMP-like_OB-fold | SUPERFAMILY | Tissue inhibitor of metalloproteinases-like, OB-fold |
Terpenoid_cyclase/PrenylTrfase | SUPERFAMILY | Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid |
A2M_N | Pfam | Alpha-2-macroglobulin, N-terminal |
A-macroglobulin_rcpt-bd_sf | SUPERFAMILY | Alpha-macroglobulin, receptor-binding domain superfamily |
A-macroglobulin_rcpt-bd_sf | Gene3D | Alpha-macroglobulin, receptor-binding domain superfamily |
MacrogloblnA2_thiol-ester-bond | Pfam | Alpha-2-macroglobulin, thiol-ester bond-forming |
GO Term | Annotation Origin | Type |
---|---|---|
immune system process | Orthology | biological process |
serine-type endopeptidase activity | Orthology | molecular function |
receptor binding | Orthology | molecular function |
protein binding | Orthology | molecular function |
extracellular region | Orthology | cellular component |
extracellular space | Orthology | cellular component |
endoplasmic reticulum lumen | Orthology | cellular component |
plasma membrane | Orthology | cellular component |
proteolysis | Orthology | biological process |
chemotaxis | Orthology | biological process |
immune response | Orthology | biological process |
signal transduction | Orthology | biological process |
cell surface receptor signaling pathway | Orthology | biological process |
G-protein coupled receptor signaling pathway | Orthology | biological process |
cell surface | Blast | cellular component |
membrane | Blast | cellular component |
macromolecular complex | Orthology | cellular component |
innate immune response | Orthology | biological process |
extracellular exosome | Orthology | cellular component |
cell junction | Orthology | cellular component |
axon | Orthology | cellular component |
cell projection | Orthology | cellular component |
neuronal cell body | Orthology | cellular component |
synapse | Orthology | cellular component |
positive regulation of catalytic activity | Orthology | biological process |
intracellular signal transduction | Orthology | biological process |
protein serine/threonine kinase activity | Orthology | molecular function |
positive regulation of signal transduction | Orthology | biological process |
protein phosphorylation | Orthology | biological process |
endopeptidase activity | Orthology | molecular function |
enzyme regulator activity | Orthology | molecular function |
enzyme binding | Orthology | molecular function |
integral component of plasma membrane | Orthology | cellular component |
organic substance metabolic process | Orthology | biological process |
cellular metabolic process | Orthology | biological process |
membrane organization | Orthology | biological process |
organelle organization | Orthology | biological process |
defense response | Orthology | biological process |
protein metabolic process | Orthology | biological process |
cell migration | Orthology | biological process |
molecular function regulator | Orthology | molecular function |
signaling receptor activity | Orthology | molecular function |
regulation of signal transduction | Orthology | biological process |
cellular process | Orthology | biological process |
intracellular organelle part | Orthology | cellular component |
cytoplasmic vesicle | Orthology | cellular component |
endomembrane system | Orthology | cellular component |
intracellular organelle lumen | Orthology | cellular component |
lysosome | Orthology | cellular component |
vacuolar part | Orthology | cellular component |
cellular protein modification process | Orthology | biological process |
angiogenesis | Orthology | biological process |
binding | Orthology | molecular function |
peptidase activity | Blast | molecular function |
whole membrane | Blast | cellular component |
bounding membrane of organelle | Blast | cellular component |
intrinsic component of membrane | Blast | cellular component |
GO Term | SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae |
Type |
---|---|---|
activation of MAPK activity | Hs | biological process |
positive regulation of protein phosphorylation | Hs | biological process |
immune system process | Hs | biological process |
serine-type endopeptidase activity | Hs | molecular function |
endopeptidase inhibitor activity | Hs | molecular function |
receptor binding | Hs | molecular function |
protein binding | Hs | molecular function |
extracellular region | Hs | cellular component |
membrane attack complex | Hs | cellular component |
extracellular space | Hs | cellular component |
endoplasmic reticulum lumen | Hs | cellular component |
plasma membrane | Hs | cellular component |
proteolysis | Hs | biological process |
lipid metabolic process | Hs | biological process |
fatty acid metabolic process | Hs | biological process |
phagocytosis, engulfment | Hs | biological process |
chemotaxis | Hs | biological process |
inflammatory response | Hs | biological process |
immune response | Hs | biological process |
complement activation | Hs | biological process |
complement activation, alternative pathway | Hs | biological process |
complement activation, classical pathway | Hs | biological process |
signal transduction | Hs | biological process |
cell surface receptor signaling pathway | Hs | biological process |
G-protein coupled receptor signaling pathway | Hs | biological process |
chemokine activity | Hs | molecular function |
positive regulation of vascular endothelial growth factor production | Hs | biological process |
regulation of triglyceride biosynthetic process | Hs | biological process |
positive regulation of lipid storage | Hs | biological process |
negative regulation of endopeptidase activity | Hs | biological process |
cytolysis | Hs | biological process |
C5L2 anaphylatoxin chemotactic receptor binding | Hs | molecular function |
macromolecular complex | Hs | cellular component |
secretory granule lumen | Hs | cellular component |
azurophil granule lumen | Hs | cellular component |
post-translational protein modification | Hs | biological process |
innate immune response | Hs | biological process |
positive regulation of G-protein coupled receptor protein signaling pathway | Hs | biological process |
positive regulation of angiogenesis | Hs | biological process |
positive regulation of phagocytosis | Hs | biological process |
regulation of immune response | Hs | biological process |
cell chemotaxis | Hs | biological process |
extracellular exosome | Hs | cellular component |
blood microparticle | Hs | cellular component |
complement binding | Hs | molecular function |
complement component C1q binding | Hs | molecular function |
cell junction | Hs | cellular component |
carbohydrate binding | Hs | molecular function |
axon | Hs | cellular component |
dendrite | Hs | cellular component |
cell projection | Hs | cellular component |
neuronal cell body | Hs | cellular component |
other organism cell | Hs | cellular component |
synapse | Hs | cellular component |
GO Term | SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae |
Type | Score | E-value |
---|---|---|---|---|
serine-type endopeptidase activity | Hs | molecular function | 232 | 5.07e-61 |
endopeptidase inhibitor activity | Hs | molecular function | 232 | 5.07e-61 |
serine-type endopeptidase inhibitor activity | Hs | molecular function | 200 | 2.12e-51 |
receptor binding | Hs | molecular function | 232 | 5.07e-61 |
protein binding | Hs | molecular function | 232 | 5.07e-61 |
extracellular region | Hs | cellular component | 232 | 5.07e-61 |
membrane attack complex | Hs | cellular component | 199 | 3.54e-51 |
extracellular space | Hs | cellular component | 232 | 5.07e-61 |
endoplasmic reticulum lumen | Hs | cellular component | 232 | 5.07e-61 |
plasma membrane | Hs | cellular component | 232 | 5.07e-61 |
chemokine activity | Hs | molecular function | 199 | 3.54e-51 |
cell surface | Hs | cellular component | 200 | 2.12e-51 |
membrane | Hs | cellular component | 200 | 2.12e-51 |
peptidase inhibitor activity | Hs | molecular function | 200 | 2.12e-51 |
platelet alpha granule membrane | Hs | cellular component | 200 | 2.12e-51 |
anchored component of membrane | Hs | cellular component | 200 | 2.12e-51 |
C5L2 anaphylatoxin chemotactic receptor binding | Hs | molecular function | 232 | 5.07e-61 |
macromolecular complex | Hs | cellular component | 232 | 5.07e-61 |
secretory granule lumen | Hs | cellular component | 232 | 5.07e-61 |
azurophil granule lumen | Hs | cellular component | 232 | 5.07e-61 |
transforming growth factor beta binding | Hs | molecular function | 200 | 2.12e-51 |
extracellular exosome | Hs | cellular component | 232 | 5.07e-61 |
blood microparticle | Hs | cellular component | 232 | 5.07e-61 |
GO Term | Analysis | Type | e-value |
---|---|---|---|
endopeptidase inhibitor activity | SMART | molecular function | 1.3E-17 |
protein binding | ProSiteProfiles | molecular function | 9.177 |
extracellular region | Gene3D | cellular component | 2.6E-134 |
extracellular space | Pfam | cellular component | 1.8E-74 |