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GENE CARD

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Gene Card

Best human hits

C3; C5; CD109

Unique Gene ID

Cirobu.g00000199

Gene Model ID

KH2012:KH.C1.1179

Location

KhC1:8335014..8362599

External Database Gene Card

External database links

No result

Collections

Gene collection 1 (N. Satoh)

2 results

ciad011b22

Plate: R1CiGC02i03

ciad028a04

Plate: R1CiGC03f03

WashU Genome Browser

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Genomicus Synteny Browser

Genomicus browser link

Regulatory Regions

Regulatory Regions

No result

n/a

Gene Phylogeny

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Gene Annotations

InterPro

17 results

IPR Term Analysis Definition
MacrogloblnA2_CS ProSitePatterns Alpha-2-macroglobulin, conserved site
A-macroglobulin_rcpt-bd SMART Alpha-macroglobulin, receptor-binding
Netrin_domain ProSiteProfiles Netrin domain
A2M_N_2 Pfam Alpha-2-macroglobulin, N-terminal 2
Macroglobln_a2 SMART Alpha-2-macroglobulin
Macroglobln_a2 Pfam Alpha-2-macroglobulin
Netrin_module_non-TIMP Pfam Netrin module, non-TIMP type
A-macroglobulin_rcpt-bd Pfam Alpha-macroglobulin, receptor-binding
Ig-like_fold Gene3D Immunoglobulin-like fold
A2M_N_2 SMART Alpha-2-macroglobulin, N-terminal 2
A2M_comp Pfam Alpha-macroglobulin complement component
TIMP-like_OB-fold SUPERFAMILY Tissue inhibitor of metalloproteinases-like, OB-fold
Terpenoid_cyclase/PrenylTrfase SUPERFAMILY Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
A2M_N Pfam Alpha-2-macroglobulin, N-terminal
A-macroglobulin_rcpt-bd_sf SUPERFAMILY Alpha-macroglobulin, receptor-binding domain superfamily
A-macroglobulin_rcpt-bd_sf Gene3D Alpha-macroglobulin, receptor-binding domain superfamily
MacrogloblnA2_thiol-ester-bond Pfam Alpha-2-macroglobulin, thiol-ester bond-forming

GOSlim

57 results

GO Term Annotation Origin Type
immune system process Orthology biological process
serine-type endopeptidase activity Orthology molecular function
receptor binding Orthology molecular function
protein binding Orthology molecular function
extracellular region Orthology cellular component
extracellular space Orthology cellular component
endoplasmic reticulum lumen Orthology cellular component
plasma membrane Orthology cellular component
proteolysis Orthology biological process
chemotaxis Orthology biological process
immune response Orthology biological process
signal transduction Orthology biological process
cell surface receptor signaling pathway Orthology biological process
G-protein coupled receptor signaling pathway Orthology biological process
cell surface Blast cellular component
membrane Blast cellular component
macromolecular complex Orthology cellular component
innate immune response Orthology biological process
extracellular exosome Orthology cellular component
cell junction Orthology cellular component
axon Orthology cellular component
cell projection Orthology cellular component
neuronal cell body Orthology cellular component
synapse Orthology cellular component
positive regulation of catalytic activity Orthology biological process
intracellular signal transduction Orthology biological process
protein serine/threonine kinase activity Orthology molecular function
positive regulation of signal transduction Orthology biological process
protein phosphorylation Orthology biological process
endopeptidase activity Orthology molecular function
enzyme regulator activity Orthology molecular function
enzyme binding Orthology molecular function
integral component of plasma membrane Orthology cellular component
organic substance metabolic process Orthology biological process
cellular metabolic process Orthology biological process
membrane organization Orthology biological process
organelle organization Orthology biological process
defense response Orthology biological process
protein metabolic process Orthology biological process
cell migration Orthology biological process
molecular function regulator Orthology molecular function
signaling receptor activity Orthology molecular function
regulation of signal transduction Orthology biological process
cellular process Orthology biological process
intracellular organelle part Orthology cellular component
cytoplasmic vesicle Orthology cellular component
endomembrane system Orthology cellular component
intracellular organelle lumen Orthology cellular component
lysosome Orthology cellular component
vacuolar part Orthology cellular component
cellular protein modification process Orthology biological process
angiogenesis Orthology biological process
binding Orthology molecular function
peptidase activity Blast molecular function
whole membrane Blast cellular component
bounding membrane of organelle Blast cellular component
intrinsic component of membrane Blast cellular component

GO (Orthology)

54 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae
Type
activation of MAPK activity Hs biological process
positive regulation of protein phosphorylation Hs biological process
immune system process Hs biological process
serine-type endopeptidase activity Hs molecular function
endopeptidase inhibitor activity Hs molecular function
receptor binding Hs molecular function
protein binding Hs molecular function
extracellular region Hs cellular component
membrane attack complex Hs cellular component
extracellular space Hs cellular component
endoplasmic reticulum lumen Hs cellular component
plasma membrane Hs cellular component
proteolysis Hs biological process
lipid metabolic process Hs biological process
fatty acid metabolic process Hs biological process
phagocytosis, engulfment Hs biological process
chemotaxis Hs biological process
inflammatory response Hs biological process
immune response Hs biological process
complement activation Hs biological process
complement activation, alternative pathway Hs biological process
complement activation, classical pathway Hs biological process
signal transduction Hs biological process
cell surface receptor signaling pathway Hs biological process
G-protein coupled receptor signaling pathway Hs biological process
chemokine activity Hs molecular function
positive regulation of vascular endothelial growth factor production Hs biological process
regulation of triglyceride biosynthetic process Hs biological process
positive regulation of lipid storage Hs biological process
negative regulation of endopeptidase activity Hs biological process
cytolysis Hs biological process
C5L2 anaphylatoxin chemotactic receptor binding Hs molecular function
macromolecular complex Hs cellular component
secretory granule lumen Hs cellular component
azurophil granule lumen Hs cellular component
post-translational protein modification Hs biological process
innate immune response Hs biological process
positive regulation of G-protein coupled receptor protein signaling pathway Hs biological process
positive regulation of angiogenesis Hs biological process
positive regulation of phagocytosis Hs biological process
regulation of immune response Hs biological process
cell chemotaxis Hs biological process
extracellular exosome Hs cellular component
blood microparticle Hs cellular component
complement binding Hs molecular function
complement component C1q binding Hs molecular function
cell junction Hs cellular component
carbohydrate binding Hs molecular function
axon Hs cellular component
dendrite Hs cellular component
cell projection Hs cellular component
neuronal cell body Hs cellular component
other organism cell Hs cellular component
synapse Hs cellular component

GO (Blast)

23 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae
Type Score E-value
serine-type endopeptidase activity Hs molecular function 232 5.07e-61
endopeptidase inhibitor activity Hs molecular function 232 5.07e-61
serine-type endopeptidase inhibitor activity Hs molecular function 200 2.12e-51
receptor binding Hs molecular function 232 5.07e-61
protein binding Hs molecular function 232 5.07e-61
extracellular region Hs cellular component 232 5.07e-61
membrane attack complex Hs cellular component 199 3.54e-51
extracellular space Hs cellular component 232 5.07e-61
endoplasmic reticulum lumen Hs cellular component 232 5.07e-61
plasma membrane Hs cellular component 232 5.07e-61
chemokine activity Hs molecular function 199 3.54e-51
cell surface Hs cellular component 200 2.12e-51
membrane Hs cellular component 200 2.12e-51
peptidase inhibitor activity Hs molecular function 200 2.12e-51
platelet alpha granule membrane Hs cellular component 200 2.12e-51
anchored component of membrane Hs cellular component 200 2.12e-51
C5L2 anaphylatoxin chemotactic receptor binding Hs molecular function 232 5.07e-61
macromolecular complex Hs cellular component 232 5.07e-61
secretory granule lumen Hs cellular component 232 5.07e-61
azurophil granule lumen Hs cellular component 232 5.07e-61
transforming growth factor beta binding Hs molecular function 200 2.12e-51
extracellular exosome Hs cellular component 232 5.07e-61
blood microparticle Hs cellular component 232 5.07e-61

GO (InterProScan)

4 results

GO Term Analysis Type e-value
endopeptidase inhibitor activity SMART molecular function 1.3E-17
protein binding ProSiteProfiles molecular function 9.177
extracellular region Gene3D cellular component 2.6E-134
extracellular space Pfam cellular component 1.8E-74