Gene Card
Best human hits
EXD3; EXOSC10; WRN
Unique Gene ID
Cirobu.g00003968
Gene Model ID
KH2012:KH.C14.524
Location
KhC14:313640..317931
Transcript Models and Sequences
Database | Gene ID |
---|---|
ENSEMBL | ENSCING00000002381 |
NCBI Reference Sequence | XM_009862464.1 |
n/a
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You can Press 'Ctrl' Key + Left Mouse Click on nodes to do a multiple selection.

IPR Term | Analysis | Definition |
---|---|---|
HRDC-like_sf | SUPERFAMILY | HRDC-like superfamily |
HRDC_dom | ProSiteProfiles | HRDC domain |
3'-5'_exonuclease_dom | SMART | 3'-5' exonuclease domain |
HRDC_dom | Pfam | HRDC domain |
HRDC_dom | SMART | HRDC domain |
RNaseH-like_sf | SUPERFAMILY | Ribonuclease H-like superfamily |
3'-5'_exonuclease_dom | Pfam | 3'-5' exonuclease domain |
GO Term | Annotation Origin | Type |
---|---|---|
nucleotide binding | Blast | molecular function |
magnesium ion binding | Blast | molecular function |
nucleic acid binding | Blast | molecular function |
DNA binding | Blast | molecular function |
chromatin binding | Blast | molecular function |
RNA binding | Blast | molecular function |
catalytic activity | Blast | molecular function |
protein binding | Blast | molecular function |
ATP binding | Blast | molecular function |
intracellular | Blast | cellular component |
nucleus | Blast | cellular component |
nucleoplasm | Blast | cellular component |
nucleolus | Blast | cellular component |
cytoplasm | Blast | cellular component |
centrosome | Blast | cellular component |
cytosol | Blast | cellular component |
nucleobase-containing compound metabolic process | InterProScan | biological process |
membrane | Blast | cellular component |
nuclear speck | Blast | cellular component |
hydrolase activity | Blast | molecular function |
protein homodimerization activity | Blast | molecular function |
neuron projection | Blast | cellular component |
cellular metabolic process | InterProScan | biological process |
macromolecular complex binding | Blast | molecular function |
metal ion binding | Blast | molecular function |
RNA metabolic process | Blast | biological process |
nuclear lumen | Blast | cellular component |
macromolecular complex | Blast | cellular component |
intracellular part | Blast | cellular component |
intracellular organelle part | Blast | cellular component |
intracellular non-membrane-bounded organelle | Blast | cellular component |
organelle organization | Blast | biological process |
nucleoside-triphosphatase activity | Blast | molecular function |
transition metal ion binding | Blast | molecular function |
nuclear part | Blast | cellular component |
sequence-specific DNA binding | Blast | molecular function |
GO Term | SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae |
Type |
---|
GO Term | SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae |
Type | Score | E-value |
---|---|---|---|---|
nucleotide binding | Hs | molecular function | 423 | 8.10e-137 |
3'-5'-exoribonuclease activity | Hs | molecular function | 423 | 8.10e-137 |
nuclear exosome (RNase complex) | Hs | cellular component | 423 | 8.10e-137 |
exosome (RNase complex) | Hs | cellular component | 423 | 8.10e-137 |
magnesium ion binding | Hs | molecular function | 40.8 | 0.003 |
four-way junction DNA binding | Hs | molecular function | 40.8 | 0.003 |
Y-form DNA binding | Hs | molecular function | 40.8 | 0.003 |
bubble DNA binding | Hs | molecular function | 40.8 | 0.003 |
chromosome, telomeric region | Hs | cellular component | 40.8 | 0.003 |
nucleic acid binding | Hs | molecular function | 423 | 8.10e-137 |
DNA binding | Hs | molecular function | 40.8 | 0.003 |
DNA helicase activity | Hs | molecular function | 40.8 | 0.003 |
chromatin binding | Hs | molecular function | 40.8 | 0.003 |
RNA binding | Hs | molecular function | 423 | 8.10e-137 |
catalytic activity | Hs | molecular function | 423 | 8.10e-137 |
ATP-dependent DNA helicase activity | Hs | molecular function | 40.8 | 0.003 |
helicase activity | Hs | molecular function | 40.8 | 0.003 |
nuclease activity | Hs | molecular function | 423 | 8.10e-137 |
exonuclease activity | Hs | molecular function | 423 | 8.10e-137 |
exoribonuclease activity | Hs | molecular function | 423 | 8.10e-137 |
protein binding | Hs | molecular function | 423 | 8.10e-137 |
ATP binding | Hs | molecular function | 40.8 | 0.003 |
intracellular | Hs | cellular component | 423 | 8.10e-137 |
nucleus | Hs | cellular component | 423 | 8.10e-137 |
nucleoplasm | Hs | cellular component | 423 | 8.10e-137 |
replication fork | Hs | cellular component | 40.8 | 0.003 |
nucleolus | Hs | cellular component | 423 | 8.10e-137 |
cytoplasm | Hs | cellular component | 423 | 8.10e-137 |
centrosome | Hs | cellular component | 40.8 | 0.003 |
cytosol | Hs | cellular component | 423 | 8.10e-137 |
ATP-dependent helicase activity | Hs | molecular function | 40.8 | 0.003 |
3'-5' exonuclease activity | Hs | molecular function | 423 | 8.10e-137 |
four-way junction helicase activity | Hs | molecular function | 40.8 | 0.003 |
membrane | Hs | cellular component | 423 | 8.10e-137 |
nuclear speck | Hs | cellular component | 40.8 | 0.003 |
hydrolase activity | Hs | molecular function | 423 | 8.10e-137 |
ATPase activity | Hs | molecular function | 40.8 | 0.003 |
manganese ion binding | Hs | molecular function | 40.8 | 0.003 |
MutLalpha complex | Hs | cellular component | 40.8 | 0.003 |
transcriptionally active chromatin | Hs | cellular component | 423 | 8.10e-137 |
protein homodimerization activity | Hs | molecular function | 40.8 | 0.003 |
neuron projection | Hs | cellular component | 40.8 | 0.003 |
3'-5' DNA helicase activity | Hs | molecular function | 40.8 | 0.003 |
ATP-dependent 3'-5' DNA helicase activity | Hs | molecular function | 40.8 | 0.003 |
macromolecular complex binding | Hs | molecular function | 40.8 | 0.003 |
metal ion binding | Hs | molecular function | 40.8 | 0.003 |
G-quadruplex DNA binding | Hs | molecular function | 40.8 | 0.003 |
forked DNA-dependent helicase activity | Hs | molecular function | 40.8 | 0.003 |
telomeric D-loop binding | Hs | molecular function | 40.8 | 0.003 |
telomeric G-quadruplex DNA binding | Hs | molecular function | 40.8 | 0.003 |
telomerase RNA binding | Hs | molecular function | 423 | 8.10e-137 |
3'-flap-structured DNA binding | Hs | molecular function | 40.8 | 0.003 |
8-hydroxy-2'-deoxyguanosine DNA binding | Hs | molecular function | 40.8 | 0.003 |
GO Term | Analysis | Type | e-value |
---|---|---|---|
nucleotide binding | SUPERFAMILY | molecular function | 1.99E-21 |
nucleic acid binding | SMART | molecular function | 1.3E-48 |
catalytic activity | SUPERFAMILY | molecular function | 1.99E-21 |
intracellular | SMART | cellular component | 5.8E-13 |
nucleobase-containing compound metabolic process | SMART | biological process | 1.3E-48 |
3'-5' exonuclease activity | SMART | molecular function | 1.3E-48 |
cellular metabolic process | SUPERFAMILY | biological process | 1.99E-21 |