Gene Card
Best human hits
ARHGEF17; ECT2; FGD6
Unique Gene ID
Cirobu.g00006283
Gene Model ID
KH2012:KH.C4.21
Location
KhC4:3665502..3673953
Transcript Models and Sequences
KH2012:KH.C4.21.v1.A.nonSL5-1
KH2012:KH.C4.21.v1.A.nonSL6-1
KH2012:KH.C4.21.v1.A.nonSL7-1
KH2012:KH.C4.21.v1.A.nonSL8-1
KH2012:KH.C4.21.v1.R.ND2-1
KH2012:KH.C4.21.v2.A.SL11-1
KH2012:KH.C4.21.v2.A.SL3-1
KH2012:KH.C4.21.v2.A.SL9-1
KH2012:KH.C4.21.v2.R.ND1-1
KH2012:KH.C4.21.v3.A.SL4-1
KH2012:KH.C4.21.v4.A.SL10-1
Database | Gene ID |
---|---|
ENSEMBL | ENSCING00000013517 |
ENSEMBL | ENSCING00000013518 |
NCBI Reference Sequence | XM_009860026.2 |
cima814573
Plate: VES58_D17
cien167500
Plate: VES96_A06
cign053b18
Plate: R1CiGC42j23
n/a
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IPR Term | Analysis | Definition |
---|---|---|
DH-domain | Pfam | Dbl homology (DH) domain |
GDS_CDC24_CS | ProSitePatterns | Guanine-nucleotide dissociation stimulator, CDC24, conserved site |
DH-domain | CDD | Dbl homology (DH) domain |
DH-domain | ProSiteProfiles | Dbl homology (DH) domain |
DH-domain | SMART | Dbl homology (DH) domain |
DBL_dom_sf | SUPERFAMILY | Dbl homology (DH) domain superfamily |
PH-like_dom_sf | Gene3D | PH-like domain superfamily |
Ect2 | PANTHER | Guanine nucleotide exchange factor Ect2 |
DBL_dom_sf | Gene3D | Dbl homology (DH) domain superfamily |
GO Term | Annotation Origin | Type |
---|---|---|
cell morphogenesis | InterProScan | biological process |
signal transducer activity | Blast | molecular function |
GTPase activator activity | Blast | molecular function |
protein binding | Orthology | molecular function |
nucleus | Blast | cellular component |
cytoplasm | Blast | cellular component |
Golgi apparatus | Blast | cellular component |
cytosol | Blast | cellular component |
cytoskeleton | Blast | cellular component |
lamellipodium | Blast | cellular component |
cell junction | Blast | cellular component |
midbody | Blast | cellular component |
intracellular signal transduction | InterProScan | biological process |
protein homodimerization activity | Blast | molecular function |
metal ion binding | Blast | molecular function |
cell division | InterProScan | biological process |
regulation of molecular function | Orthology | biological process |
enzyme binding | Orthology | molecular function |
molecular function regulator | Orthology | molecular function |
small GTPase mediated signal transduction | Orthology | biological process |
regulation of signal transduction | Orthology | biological process |
cell projection | Blast | cellular component |
plasma membrane region | Blast | cellular component |
cell leading edge | Blast | cellular component |
cytoskeletal part | Blast | cellular component |
microtubule cytoskeleton | Blast | cellular component |
macromolecular complex | Blast | cellular component |
membrane organization | InterProScan | biological process |
cell development | InterProScan | biological process |
neuron differentiation | InterProScan | biological process |
GO Term | SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae |
Type |
---|---|---|
guanyl-nucleotide exchange factor activity | Hs | molecular function |
Rho guanyl-nucleotide exchange factor activity | Hs | molecular function |
protein binding | Hs | molecular function |
regulation of Rho protein signal transduction | Hs | biological process |
regulation of molecular function | Hs | biological process |
GO Term | SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae |
Type | Score | E-value |
---|---|---|---|---|
ruffle | Hs | cellular component | 82.4 | 3.12e-16 |
signal transducer activity | Hs | molecular function | 283 | 5.54e-85 |
guanyl-nucleotide exchange factor activity | Hs | molecular function | 283 | 5.54e-85 |
Rho guanyl-nucleotide exchange factor activity | Hs | molecular function | 283 | 5.54e-85 |
GTPase activator activity | Hs | molecular function | 283 | 5.54e-85 |
protein binding | Hs | molecular function | 283 | 5.54e-85 |
nucleus | Hs | cellular component | 283 | 5.54e-85 |
cytoplasm | Hs | cellular component | 283 | 5.54e-85 |
Golgi apparatus | Hs | cellular component | 82.4 | 3.12e-16 |
spindle | Hs | cellular component | 283 | 5.54e-85 |
cytosol | Hs | cellular component | 283 | 5.54e-85 |
cytoskeleton | Hs | cellular component | 283 | 5.54e-85 |
cell-cell junction | Hs | cellular component | 283 | 5.54e-85 |
bicellular tight junction | Hs | cellular component | 283 | 5.54e-85 |
Rho GTPase binding | Hs | molecular function | 283 | 5.54e-85 |
lamellipodium | Hs | cellular component | 82.4 | 3.12e-16 |
cell junction | Hs | cellular component | 283 | 5.54e-85 |
midbody | Hs | cellular component | 283 | 5.54e-85 |
small GTPase binding | Hs | molecular function | 82.4 | 3.12e-16 |
cleavage furrow | Hs | cellular component | 283 | 5.54e-85 |
protein homodimerization activity | Hs | molecular function | 283 | 5.54e-85 |
metal ion binding | Hs | molecular function | 82.4 | 3.12e-16 |
mitotic spindle | Hs | cellular component | 283 | 5.54e-85 |
centralspindlin complex | Hs | cellular component | 283 | 5.54e-85 |
GO Term | Analysis | Type | e-value |
---|---|---|---|
cell morphogenesis | PANTHER | biological process | 3.0E-113 |
cytokinesis | PANTHER | biological process | 3.0E-113 |
guanyl-nucleotide exchange factor activity | PANTHER | molecular function | 3.0E-113 |
Rho guanyl-nucleotide exchange factor activity | SMART | molecular function | 7.6E-45 |
GTPase activator activity | PANTHER | molecular function | 3.0E-113 |
nucleus | PANTHER | cellular component | 3.0E-113 |
cytoplasm | PANTHER | cellular component | 3.0E-113 |
regulation of Rho protein signal transduction | SMART | biological process | 7.6E-45 |
intracellular signal transduction | ProSitePatterns | biological process | |
positive regulation of neuron differentiation | PANTHER | biological process | 3.0E-113 |