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GENE CARD

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  1. Gene 'Phfumi.CG.MTP2014.S1...'

Gene Card

Best human hits

ITCH; SMURF1; SMURF2

Unique Gene ID

Cirobu.g00006542

Gene Model ID

KH2012:KH.C4.45

Location

KhC4:1252291..1269066

External Database Gene Card
Collections

Gateway full ORF

1 result

cien54497

Plate: VES78_B18

Gene collection 1 (N. Satoh)

1 result

cieg028a21

Plate: R1CiGC20g07

WashU Genome Browser

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Genomicus Synteny Browser

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Regulatory Regions

Regulatory Regions

No result

n/a

Gene Phylogeny

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Gene Annotations

InterPro

16 results

IPR Term Analysis Definition
C2_dom Pfam C2 domain
WW_dom SMART WW domain
WW_dom CDD WW domain
HECT_dom ProSiteProfiles HECT domain
C2_dom ProSiteProfiles C2 domain
Hect_E3_ubiquitin_ligase SUPERFAMILY HECT, E3 ligase catalytic domain
C2_domain_sf Gene3D C2 domain superfamily
WW_dom_sf SUPERFAMILY WW domain superfamily
WW_dom ProSitePatterns WW domain
WW_dom ProSiteProfiles WW domain
E3_ub_ligase_SMURF1 PIRSF E3 ubiquitin-protein ligase, SMURF1 type
WW_dom Pfam WW domain
HECT_dom CDD HECT domain
C2_dom SMART C2 domain
HECT_dom Pfam HECT domain
HECT_dom SMART HECT domain

GOSlim

56 results

GO Term Annotation Origin Type
negative regulation of transcription from RNA polymerase II promoter Orthology biological process
protein polyubiquitination Orthology biological process
ubiquitin-protein transferase activity Orthology molecular function
protein binding Orthology molecular function
nucleus Orthology cellular component
nucleoplasm Orthology cellular component
cytoplasm Orthology cellular component
mitochondrion Orthology cellular component
endosome Blast cellular component
early endosome Blast cellular component
cytosol Orthology cellular component
plasma membrane Orthology cellular component
membrane Orthology cellular component
protein ubiquitination Orthology biological process
nuclear speck Orthology cellular component
transferase activity Orthology molecular function
ligase activity Blast molecular function
ubiquitin-like protein transferase activity Blast molecular function
cell differentiation Orthology biological process
axon Orthology cellular component
cytoplasmic vesicle Blast cellular component
macromolecular complex Orthology cellular component
identical protein binding Orthology molecular function
neuronal cell body Orthology cellular component
intracellular membrane-bounded organelle Blast cellular component
ubiquitin-like protein ligase binding Blast molecular function
membrane raft Orthology cellular component
negative regulation of transcription, DNA-templated Orthology biological process
extracellular exosome Orthology cellular component
positive regulation of canonical Wnt signaling pathway Orthology biological process
intracellular part Orthology cellular component
receptor binding Orthology molecular function
anion binding Orthology molecular function
proteolysis Orthology biological process
intracellular protein transport Orthology biological process
cell surface receptor signaling pathway Orthology biological process
cellular response to organic substance Orthology biological process
anatomical structure development Orthology biological process
peptidase activity, acting on L-amino acid peptides Orthology molecular function
regulation of signal transduction Orthology biological process
regulation of transcription from RNA polymerase II promoter Orthology biological process
negative regulation of signal transduction Orthology biological process
cellular protein localization Orthology biological process
macromolecular complex binding Orthology molecular function
cell-cell signaling Orthology biological process
anatomical structure morphogenesis Orthology biological process
animal organ development Orthology biological process
protein localization to membrane Orthology biological process
cell migration Orthology biological process
multicellular organism development Orthology biological process
neuron projection morphogenesis Orthology biological process
cell periphery Blast cellular component
cytoplasmic part Blast cellular component
intracellular organelle part Blast cellular component
whole membrane Blast cellular component
bounding membrane of organelle Blast cellular component

GO (Orthology)

49 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae
Type
negative regulation of transcription from RNA polymerase II promoter Hs biological process
ubiquitin ligase complex Hs cellular component
protein polyubiquitination Hs biological process
ubiquitin-protein transferase activity Hs molecular function
transforming growth factor beta receptor binding Hs molecular function
protein binding Hs molecular function
phospholipid binding Hs molecular function
nucleus Hs cellular component
nucleoplasm Hs cellular component
cytoplasm Hs cellular component
mitochondrion Hs cellular component
cytosol Hs cellular component
plasma membrane Hs cellular component
ubiquitin-dependent protein catabolic process Hs biological process
protein export from nucleus Hs biological process
transforming growth factor beta receptor signaling pathway Hs biological process
ectoderm development Hs biological process
membrane Hs cellular component
protein ubiquitination Hs biological process
protein deubiquitination Hs biological process
nuclear speck Hs cellular component
transferase activity Hs molecular function
regulation of transforming growth factor beta receptor signaling pathway Hs biological process
cell differentiation Hs biological process
negative regulation of ossification Hs biological process
axon Hs cellular component
BMP signaling pathway Hs biological process
negative regulation of transforming growth factor beta receptor signaling pathway Hs biological process
negative regulation of BMP signaling pathway Hs biological process
ubiquitin-dependent SMAD protein catabolic process Hs biological process
receptor catabolic process Hs biological process
protein localization to cell surface Hs biological process
identical protein binding Hs molecular function
neuronal cell body Hs cellular component
proteasome-mediated ubiquitin-dependent protein catabolic process Hs biological process
membrane raft Hs cellular component
negative regulation of transcription, DNA-templated Hs biological process
SMAD binding Hs molecular function
activin binding Hs molecular function
Wnt signaling pathway, planar cell polarity pathway Hs biological process
ubiquitin protein ligase activity Hs molecular function
extracellular exosome Hs cellular component
I-SMAD binding Hs molecular function
R-SMAD binding Hs molecular function
protein localization to plasma membrane Hs biological process
positive regulation of canonical Wnt signaling pathway Hs biological process
positive regulation of trophoblast cell migration Hs biological process
positive regulation of dendrite extension Hs biological process
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process Hs biological process

GO (Blast)

38 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae
Type Score E-value
ubiquitin ligase complex Hs cellular component 1053 0.0
ubiquitin-protein transferase activity Hs molecular function 1053 0.0
transforming growth factor beta receptor binding Hs molecular function 1053 0.0
protein binding Hs molecular function 1053 0.0
phospholipid binding Hs molecular function 976 0.0
nucleus Hs cellular component 1053 0.0
nucleoplasm Hs cellular component 1053 0.0
cytoplasm Hs cellular component 1053 0.0
mitochondrion Hs cellular component 976 0.0
endosome Hs cellular component 494 3.37e-163
early endosome Hs cellular component 494 3.37e-163
cytosol Hs cellular component 1053 0.0
plasma membrane Hs cellular component 1053 0.0
cell cortex Hs cellular component 494 3.37e-163
endosome membrane Hs cellular component 494 3.37e-163
membrane Hs cellular component 1053 0.0
nuclear speck Hs cellular component 1053 0.0
transferase activity Hs molecular function 1053 0.0
ligase activity Hs molecular function 494 3.37e-163
ubiquitin-like protein transferase activity Hs molecular function 494 3.37e-163
axon Hs cellular component 976 0.0
cytoplasmic vesicle Hs cellular component 494 3.37e-163
early endosome membrane Hs cellular component 494 3.37e-163
macromolecular complex Hs cellular component 494 3.37e-163
identical protein binding Hs molecular function 1053 0.0
ribonucleoprotein complex binding Hs molecular function 494 3.37e-163
neuronal cell body Hs cellular component 976 0.0
intracellular membrane-bounded organelle Hs cellular component 494 3.37e-163
ubiquitin-like protein ligase binding Hs molecular function 494 3.37e-163
membrane raft Hs cellular component 1053 0.0
CXCR chemokine receptor binding Hs molecular function 494 3.37e-163
SMAD binding Hs molecular function 1053 0.0
activin binding Hs molecular function 976 0.0
ubiquitin protein ligase activity Hs molecular function 1053 0.0
extracellular exosome Hs cellular component 976 0.0
I-SMAD binding Hs molecular function 976 0.0
R-SMAD binding Hs molecular function 976 0.0
arrestin family protein binding Hs molecular function 494 3.37e-163

GO (InterProScan)

4 results

GO Term Analysis Type e-value
ubiquitin-protein transferase activity CDD molecular function 1.75191E-162
protein binding SUPERFAMILY molecular function 7.87E-12
ubiquitin-dependent protein catabolic process PIRSF biological process 3.3E-210
ubiquitin protein ligase activity PIRSF molecular function 3.3E-210