Gene Card
Best human hits
ITCH; SMURF1; SMURF2
Unique Gene ID
Cirobu.g00006542
Gene Model ID
KH2012:KH.C4.45
Location
KhC4:1252291..1269066
Transcript Models and Sequences
KH2012:KH.C4.45.v1.A.SL1-1
KH2012:KH.C4.45.v1.A.SL3-1
KH2012:KH.C4.45.v1.A.SL4-1
KH2012:KH.C4.45.v2.A.SL2-1
cien54497
Plate: VES78_B18
cieg028a21
Plate: R1CiGC20g07
n/a
You can Right Mouse Click on internal nodes, leaves and outside the tree to see multiple options adapted to your selection.
The 'History' button on the left side permits you to see the changes you have made and eventually to go back.
You can Press 'Shift' Key + Left Mouse Click on the leaf's node to access to a gene card in a new window.
You can Press 'Ctrl' Key + Left Mouse Click on nodes to do a multiple selection.
Click here to see how you can interact with this tree
The 'History' button on the left side permits you to see the changes you have made and eventually to go back.
You can Press 'Shift' Key + Left Mouse Click on the leaf's node to access to a gene card in a new window.
You can Press 'Ctrl' Key + Left Mouse Click on nodes to do a multiple selection.

IPR Term | Analysis | Definition |
---|---|---|
C2_dom | Pfam | C2 domain |
WW_dom | SMART | WW domain |
WW_dom | CDD | WW domain |
HECT_dom | ProSiteProfiles | HECT domain |
C2_dom | ProSiteProfiles | C2 domain |
Hect_E3_ubiquitin_ligase | SUPERFAMILY | HECT, E3 ligase catalytic domain |
C2_domain_sf | Gene3D | C2 domain superfamily |
WW_dom_sf | SUPERFAMILY | WW domain superfamily |
WW_dom | ProSitePatterns | WW domain |
WW_dom | ProSiteProfiles | WW domain |
E3_ub_ligase_SMURF1 | PIRSF | E3 ubiquitin-protein ligase, SMURF1 type |
WW_dom | Pfam | WW domain |
HECT_dom | CDD | HECT domain |
C2_dom | SMART | C2 domain |
HECT_dom | Pfam | HECT domain |
HECT_dom | SMART | HECT domain |
GO Term | Annotation Origin | Type |
---|---|---|
negative regulation of transcription from RNA polymerase II promoter | Orthology | biological process |
protein polyubiquitination | Orthology | biological process |
ubiquitin-protein transferase activity | Orthology | molecular function |
protein binding | Orthology | molecular function |
nucleus | Orthology | cellular component |
nucleoplasm | Orthology | cellular component |
cytoplasm | Orthology | cellular component |
mitochondrion | Orthology | cellular component |
endosome | Blast | cellular component |
early endosome | Blast | cellular component |
cytosol | Orthology | cellular component |
plasma membrane | Orthology | cellular component |
membrane | Orthology | cellular component |
protein ubiquitination | Orthology | biological process |
nuclear speck | Orthology | cellular component |
transferase activity | Orthology | molecular function |
ligase activity | Blast | molecular function |
ubiquitin-like protein transferase activity | Blast | molecular function |
cell differentiation | Orthology | biological process |
axon | Orthology | cellular component |
cytoplasmic vesicle | Blast | cellular component |
macromolecular complex | Orthology | cellular component |
identical protein binding | Orthology | molecular function |
neuronal cell body | Orthology | cellular component |
intracellular membrane-bounded organelle | Blast | cellular component |
ubiquitin-like protein ligase binding | Blast | molecular function |
membrane raft | Orthology | cellular component |
negative regulation of transcription, DNA-templated | Orthology | biological process |
extracellular exosome | Orthology | cellular component |
positive regulation of canonical Wnt signaling pathway | Orthology | biological process |
intracellular part | Orthology | cellular component |
receptor binding | Orthology | molecular function |
anion binding | Orthology | molecular function |
proteolysis | Orthology | biological process |
intracellular protein transport | Orthology | biological process |
cell surface receptor signaling pathway | Orthology | biological process |
cellular response to organic substance | Orthology | biological process |
anatomical structure development | Orthology | biological process |
peptidase activity, acting on L-amino acid peptides | Orthology | molecular function |
regulation of signal transduction | Orthology | biological process |
regulation of transcription from RNA polymerase II promoter | Orthology | biological process |
negative regulation of signal transduction | Orthology | biological process |
cellular protein localization | Orthology | biological process |
macromolecular complex binding | Orthology | molecular function |
cell-cell signaling | Orthology | biological process |
anatomical structure morphogenesis | Orthology | biological process |
animal organ development | Orthology | biological process |
protein localization to membrane | Orthology | biological process |
cell migration | Orthology | biological process |
multicellular organism development | Orthology | biological process |
neuron projection morphogenesis | Orthology | biological process |
cell periphery | Blast | cellular component |
cytoplasmic part | Blast | cellular component |
intracellular organelle part | Blast | cellular component |
whole membrane | Blast | cellular component |
bounding membrane of organelle | Blast | cellular component |
GO Term | SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae |
Type | Score | E-value |
---|---|---|---|---|
ubiquitin ligase complex | Hs | cellular component | 1053 | 0.0 |
ubiquitin-protein transferase activity | Hs | molecular function | 1053 | 0.0 |
transforming growth factor beta receptor binding | Hs | molecular function | 1053 | 0.0 |
protein binding | Hs | molecular function | 1053 | 0.0 |
phospholipid binding | Hs | molecular function | 976 | 0.0 |
nucleus | Hs | cellular component | 1053 | 0.0 |
nucleoplasm | Hs | cellular component | 1053 | 0.0 |
cytoplasm | Hs | cellular component | 1053 | 0.0 |
mitochondrion | Hs | cellular component | 976 | 0.0 |
endosome | Hs | cellular component | 494 | 3.37e-163 |
early endosome | Hs | cellular component | 494 | 3.37e-163 |
cytosol | Hs | cellular component | 1053 | 0.0 |
plasma membrane | Hs | cellular component | 1053 | 0.0 |
cell cortex | Hs | cellular component | 494 | 3.37e-163 |
endosome membrane | Hs | cellular component | 494 | 3.37e-163 |
membrane | Hs | cellular component | 1053 | 0.0 |
nuclear speck | Hs | cellular component | 1053 | 0.0 |
transferase activity | Hs | molecular function | 1053 | 0.0 |
ligase activity | Hs | molecular function | 494 | 3.37e-163 |
ubiquitin-like protein transferase activity | Hs | molecular function | 494 | 3.37e-163 |
axon | Hs | cellular component | 976 | 0.0 |
cytoplasmic vesicle | Hs | cellular component | 494 | 3.37e-163 |
early endosome membrane | Hs | cellular component | 494 | 3.37e-163 |
macromolecular complex | Hs | cellular component | 494 | 3.37e-163 |
identical protein binding | Hs | molecular function | 1053 | 0.0 |
ribonucleoprotein complex binding | Hs | molecular function | 494 | 3.37e-163 |
neuronal cell body | Hs | cellular component | 976 | 0.0 |
intracellular membrane-bounded organelle | Hs | cellular component | 494 | 3.37e-163 |
ubiquitin-like protein ligase binding | Hs | molecular function | 494 | 3.37e-163 |
membrane raft | Hs | cellular component | 1053 | 0.0 |
CXCR chemokine receptor binding | Hs | molecular function | 494 | 3.37e-163 |
SMAD binding | Hs | molecular function | 1053 | 0.0 |
activin binding | Hs | molecular function | 976 | 0.0 |
ubiquitin protein ligase activity | Hs | molecular function | 1053 | 0.0 |
extracellular exosome | Hs | cellular component | 976 | 0.0 |
I-SMAD binding | Hs | molecular function | 976 | 0.0 |
R-SMAD binding | Hs | molecular function | 976 | 0.0 |
arrestin family protein binding | Hs | molecular function | 494 | 3.37e-163 |
GO Term | Analysis | Type | e-value |
---|---|---|---|
ubiquitin-protein transferase activity | CDD | molecular function | 1.75191E-162 |
protein binding | SUPERFAMILY | molecular function | 7.87E-12 |
ubiquitin-dependent protein catabolic process | PIRSF | biological process | 3.3E-210 |
ubiquitin protein ligase activity | PIRSF | molecular function | 3.3E-210 |