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Gene Card

Best human hits

SMAD1; SMAD4; SMAD9

Species

C. robusta formely Ciona int. type A

Unique Gene ID

Cirobu.g00007633

Gene Model ID

KH2012:KH.C6.117

Location

KhC6:1051078..1057737

Transcript Models and Sequences

  KH2012:KH.C6.117.v1.A.SL1-1

External Database Gene Card

External database links

2 results

Database Gene ID
ENSEMBL ENSCING00000005559
NCBI Reference Sequence NM_001078476.1
Collections

Gateway full ORF

2 results

cima871497

Plate: VES66_N19

cien175602

Plate: VES97_J10

Gene collection 1 (N. Satoh)

1 result

cieg009m10

Plate: R1CiGC17g09

WashU Genome Browser

Click here to view results in the tunicate WashU Browser

Genomicus Synteny Browser

Genomicus browser link

Regulatory Regions

Regulatory Regions

No result

n/a

Gene Phylogeny

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Gene Annotations

InterPro

11 results

IPR Term Analysis Definition
SMAD_MH1_sf SUPERFAMILY SMAD MH1 domain superfamily
Dwarfin PANTHER Dwarfin
SMAD-like_dom_sf Gene3D SMAD-like domain superfamily
SMAD_dom_Dwarfin-type Pfam SMAD domain, Dwarfin-type
MAD_homology1_Dwarfin-type Pfam MAD homology 1, Dwarfin-type
SMAD_dom_Dwarfin-type SMART SMAD domain, Dwarfin-type
SMAD_FHA_dom_sf SUPERFAMILY SMAD/FHA domain superfamily
MAD_homology_MH1 ProSiteProfiles MAD homology, MH1
SMAD_dom_Dwarfin-type ProSiteProfiles SMAD domain, Dwarfin-type
MAD_homology1_Dwarfin-type SMART MAD homology 1, Dwarfin-type
SMAD_MH1_sf Gene3D SMAD MH1 domain superfamily

GOSlim

76 results

GO Term Annotation Origin Type
negative regulation of transcription from RNA polymerase II promoter Orthology biological process
RNA polymerase II regulatory region sequence-specific DNA binding Orthology molecular function
RNA polymerase II core promoter proximal region sequence-specific DNA binding Orthology molecular function
RNA polymerase II transcription factor activity, sequence-specific DNA binding Orthology molecular function
core promoter proximal region sequence-specific DNA binding Orthology molecular function
transcription factor activity, transcription factor binding Orthology molecular function
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding Orthology molecular function
response to hypoxia Orthology biological process
DNA binding Orthology molecular function
chromatin binding Orthology molecular function
transcription factor activity, sequence-specific DNA binding Orthology molecular function
protein binding Orthology molecular function
intracellular Orthology cellular component
nucleus Orthology cellular component
nucleoplasm Orthology cellular component
cytoplasm Orthology cellular component
centrosome Orthology cellular component
cytosol Orthology cellular component
transcription, DNA-templated Orthology biological process
regulation of transcription, DNA-templated Orthology biological process
regulation of transcription from RNA polymerase II promoter Orthology biological process
protein phosphorylation Orthology biological process
spermatogenesis Orthology biological process
axon guidance Orthology biological process
cell proliferation Orthology biological process
negative regulation of cell proliferation Orthology biological process
integral component of membrane Blast cellular component
protein kinase binding Blast molecular function
macromolecular complex Orthology cellular component
intracellular signal transduction Orthology biological process
regulation of cell proliferation Orthology biological process
identical protein binding Orthology molecular function
protein homodimerization activity Orthology molecular function
sequence-specific DNA binding Orthology molecular function
transcription regulatory region DNA binding Orthology molecular function
negative regulation of transcription, DNA-templated Orthology biological process
positive regulation of transcription, DNA-templated Orthology biological process
positive regulation of transcription from RNA polymerase II promoter Orthology biological process
metal ion binding Orthology molecular function
protein heterodimerization activity Orthology molecular function
negative regulation of cell death Orthology biological process
intracellular non-membrane-bounded organelle Orthology cellular component
nuclear lumen Orthology cellular component
transcription factor binding Orthology molecular function
reproductive process Orthology biological process
animal organ development Orthology biological process
anatomical structure morphogenesis Orthology biological process
anatomical structure formation involved in morphogenesis Orthology biological process
multicellular organism development Orthology biological process
heart development Orthology biological process
macromolecular complex binding Orthology molecular function
intracellular part Orthology cellular component
cellular process Orthology biological process
cell Orthology cellular component
cell surface receptor signaling pathway Orthology biological process
cellular response to organic substance Orthology biological process
sexual reproduction Orthology biological process
anatomical structure development Orthology biological process
cell differentiation Orthology biological process
positive regulation of signal transduction Orthology biological process
peptidase activity, acting on L-amino acid peptides Orthology molecular function
regulation of signal transduction Orthology biological process
cellular component organization Orthology biological process
molecular transducer activity Orthology molecular function
nuclear part Orthology cellular component
developmental process Orthology biological process
anion binding Orthology molecular function
neuron differentiation Orthology biological process
organelle organization Orthology biological process
cellular protein modification process Orthology biological process
protein homooligomerization Orthology biological process
negative regulation of signal transduction Orthology biological process
organelle inner membrane Blast cellular component
nuclear membrane Blast cellular component
enzyme binding Blast molecular function
RNA binding Blast molecular function

GO (Orthology)

87 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type
negative regulation of transcription from RNA polymerase II promoter Hs biological process
nuclear chromatin Hs cellular component
RNA polymerase II regulatory region sequence-specific DNA binding Hs molecular function
RNA polymerase II core promoter proximal region sequence-specific DNA binding Hs molecular function
RNA polymerase II transcription factor activity, sequence-specific DNA binding Hs molecular function
core promoter proximal region sequence-specific DNA binding Hs molecular function
transcription factor activity, transcription factor binding Hs molecular function
transcription factor activity, RNA polymerase II transcription factor binding Hs molecular function
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding Hs molecular function
RNA polymerase II transcription factor binding Hs molecular function
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding Hs molecular function
ovarian follicle development Hs biological process
branching involved in ureteric bud morphogenesis Hs biological process
response to hypoxia Hs biological process
gastrulation with mouth forming second Hs biological process
kidney development Hs biological process
atrioventricular valve formation Hs biological process
DNA binding Hs molecular function
chromatin binding Hs molecular function
transcription factor activity, sequence-specific DNA binding Hs molecular function
protein binding Hs molecular function
collagen binding Hs molecular function
intracellular Hs cellular component
nucleus Hs cellular component
nucleoplasm Hs cellular component
transcription factor complex Hs cellular component
cytoplasm Hs cellular component
centrosome Hs cellular component
cytosol Hs cellular component
transcription, DNA-templated Hs biological process
regulation of transcription, DNA-templated Hs biological process
regulation of transcription from RNA polymerase II promoter Hs biological process
cellular iron ion homeostasis Hs biological process
transforming growth factor beta receptor signaling pathway Hs biological process
spermatogenesis Hs biological process
single fertilization Hs biological process
gastrulation Hs biological process
axon guidance Hs biological process
endoderm development Hs biological process
mesoderm development Hs biological process
cell proliferation Hs biological process
negative regulation of cell proliferation Hs biological process
male gonad development Hs biological process
female gonad development Hs biological process
anterior/posterior pattern specification Hs biological process
positive regulation of epithelial to mesenchymal transition Hs biological process
positive regulation of pathway-restricted SMAD protein phosphorylation Hs biological process
neural crest cell differentiation Hs biological process
protein deubiquitination Hs biological process
regulation of transforming growth factor beta receptor signaling pathway Hs biological process
negative regulation of cell growth Hs biological process
BMP signaling pathway Hs biological process
positive regulation of transforming growth factor beta receptor signaling pathway Hs biological process
positive regulation of BMP signaling pathway Hs biological process
transforming growth factor beta receptor, common-partner cytoplasmic mediator activity Hs molecular function
activin responsive factor complex Hs cellular component
somite rostral/caudal axis specification Hs biological process
somatic stem cell population maintenance Hs biological process
intracellular signal transduction Hs biological process
atrioventricular canal development Hs biological process
regulation of cell proliferation Hs biological process
identical protein binding Hs molecular function
protein homodimerization activity Hs molecular function
sulfate binding Hs molecular function
sequence-specific DNA binding Hs molecular function
transcription regulatory region DNA binding Hs molecular function
negative regulation of transcription, DNA-templated Hs biological process
positive regulation of transcription, DNA-templated Hs biological process
positive regulation of transcription from RNA polymerase II promoter Hs biological process
metal ion binding Hs molecular function
protein heterodimerization activity Hs molecular function
developmental growth Hs biological process
neuron fate commitment Hs biological process
tissue morphogenesis Hs biological process
formation of anatomical boundary Hs biological process
positive regulation of histone H3-K4 methylation Hs biological process
palate development Hs biological process
uterus development Hs biological process
SMAD protein signal transduction Hs biological process
negative regulation of cell death Hs biological process
endocardial cell differentiation Hs biological process
protein homotrimerization Hs biological process
negative regulation of ERK1 and ERK2 cascade Hs biological process
I-SMAD binding Hs molecular function
R-SMAD binding Hs molecular function
SMAD protein complex Hs cellular component
RNA polymerase II transcription factor complex Hs cellular component

GO (Blast)

44 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type Score E-value
nuclear chromatin Hs cellular component 668 0.0
RNA polymerase II regulatory region sequence-specific DNA binding Hs molecular function 668 0.0
RNA polymerase II core promoter proximal region sequence-specific DNA binding Hs molecular function 668 0.0
RNA polymerase II transcription factor activity, sequence-specific DNA binding Hs molecular function 668 0.0
core promoter proximal region sequence-specific DNA binding Hs molecular function 668 0.0
transcription factor activity, transcription factor binding Hs molecular function 668 0.0
transcription factor activity, RNA polymerase II transcription factor binding Hs molecular function 668 0.0
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding Hs molecular function 668 0.0
RNA polymerase II transcription factor binding Hs molecular function 668 0.0
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding Hs molecular function 668 0.0
DNA binding Hs molecular function 668 0.0
chromatin binding Hs molecular function 668 0.0
transcription factor activity, sequence-specific DNA binding Hs molecular function 668 0.0
signal transducer activity, downstream of receptor Hs molecular function 262 8.71e-82
protein binding Hs molecular function 668 0.0
collagen binding Hs molecular function 668 0.0
intracellular Hs cellular component 668 0.0
nucleus Hs cellular component 668 0.0
nuclear inner membrane Hs cellular component 262 8.71e-82
nucleoplasm Hs cellular component 668 0.0
transcription factor complex Hs cellular component 668 0.0
cytoplasm Hs cellular component 668 0.0
centrosome Hs cellular component 668 0.0
cytosol Hs cellular component 668 0.0
integral component of membrane Hs cellular component 262 8.71e-82
DEAD/H-box RNA helicase binding Hs molecular function 262 8.71e-82
protein kinase binding Hs molecular function 262 8.71e-82
transforming growth factor beta receptor, common-partner cytoplasmic mediator activity Hs molecular function 668 0.0
transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity Hs molecular function 262 8.71e-82
activin responsive factor complex Hs cellular component 668 0.0
macromolecular complex Hs cellular component 262 8.71e-82
identical protein binding Hs molecular function 668 0.0
protein homodimerization activity Hs molecular function 668 0.0
sulfate binding Hs molecular function 668 0.0
sequence-specific DNA binding Hs molecular function 668 0.0
transcription regulatory region DNA binding Hs molecular function 668 0.0
metal ion binding Hs molecular function 668 0.0
protein heterodimerization activity Hs molecular function 668 0.0
co-SMAD binding Hs molecular function 262 8.71e-82
I-SMAD binding Hs molecular function 668 0.0
R-SMAD binding Hs molecular function 668 0.0
primary miRNA binding Hs molecular function 262 8.71e-82
SMAD protein complex Hs cellular component 668 0.0
RNA polymerase II transcription factor complex Hs cellular component 668 0.0

GO (InterProScan)

6 results

GO Term Analysis Type e-value
transcription factor activity, sequence-specific DNA binding ProSiteProfiles molecular function 35.763
protein binding SUPERFAMILY molecular function 9.94E-90
intracellular PANTHER cellular component 9.0E-251
transcription factor complex ProSiteProfiles cellular component 35.763
regulation of transcription, DNA-templated PANTHER biological process 9.0E-251
transforming growth factor beta receptor signaling pathway Gene3D biological process 4.2E-62

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