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GENE CARD

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Gene Card

Best human hits

LEF1; TCF7; TCF7L2

Species

M.occidentalis

Unique Gene ID

Moocci.g00017328

Gene Model ID

Moocci.CG.ELv1_2.S484355.g17328

Location

S484355:60323..70178

Transcript Models and Sequences

  Moocci.CG.ELv1_2.S484355.g17328.01.t

External Database Gene Card

External database links

No result

Collections
WashU Genome Browser

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Genomicus Synteny Browser

Genomicus browser link

Regulatory Regions

Regulatory Regions

No result

n/a

Gene Phylogeny

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Gene Annotations

InterPro

5 results

IPR Term Analysis Definition
HMG_box_dom Pfam High mobility group box domain
HMG_box_dom SMART High mobility group box domain
HMG_box_dom_sf Gene3D High mobility group box domain superfamily
HMG_box_dom ProSiteProfiles High mobility group box domain
HMG_box_dom_sf SUPERFAMILY High mobility group box domain superfamily

GOSlim

No result

GO Term Annotation Origin Type

GO (Orthology)

124 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae
Type
negative regulation of transcription from RNA polymerase II promoter Hs biological process
nuclear chromatin Hs cellular component
RNA polymerase II regulatory region sequence-specific DNA binding Hs molecular function
RNA polymerase II core promoter proximal region sequence-specific DNA binding Hs molecular function
RNA polymerase II transcription factor activity, sequence-specific DNA binding Hs molecular function
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding Hs molecular function
RNA polymerase II repressing transcription factor binding Hs molecular function
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding Hs molecular function
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding Hs molecular function
blood vessel development Hs biological process
branching involved in blood vessel morphogenesis Hs biological process
osteoblast differentiation Hs biological process
neural crest cell migration Hs biological process
somitogenesis Hs biological process
epithelial to mesenchymal transition Hs biological process
vasculature development Hs biological process
sprouting angiogenesis Hs biological process
DNA binding Hs molecular function
chromatin binding Hs molecular function
transcription factor activity, sequence-specific DNA binding Hs molecular function
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Hs molecular function
protein binding Hs molecular function
nucleus Hs cellular component
nucleoplasm Hs cellular component
transcription factor complex Hs cellular component
nuclear euchromatin Hs cellular component
cytoplasm Hs cellular component
transcription, DNA-templated Hs biological process
regulation of transcription, DNA-templated Hs biological process
regulation of transcription from RNA polymerase II promoter Hs biological process
transcription from RNA polymerase II promoter Hs biological process
immune response Hs biological process
cell cycle arrest Hs biological process
Wnt signaling pathway, calcium modulating pathway Hs biological process
beta-catenin binding Hs molecular function
transcription factor binding Hs molecular function
cell proliferation Hs biological process
positive regulation of cell proliferation Hs biological process
DNA binding, bending Hs molecular function
response to glucose Hs biological process
positive regulation of gene expression Hs biological process
positive regulation of epithelial to mesenchymal transition Hs biological process
Wnt signaling pathway Hs biological process
regulation of striated muscle tissue development Hs biological process
nuclear body Hs cellular component
PML body Hs cellular component
protein kinase binding Hs molecular function
hypothalamus development Hs biological process
forebrain radial glial cell differentiation Hs biological process
forebrain neuroblast division Hs biological process
forebrain neuron differentiation Hs biological process
neural tube development Hs biological process
formation of radial glial scaffolds Hs biological process
regulation of cell-cell adhesion Hs biological process
regulation of Wnt signaling pathway Hs biological process
neutrophil differentiation Hs biological process
estrogen receptor activity Hs molecular function
positive regulation of cell growth Hs biological process
embryonic limb morphogenesis Hs biological process
estrogen receptor binding Hs molecular function
positive regulation of cell migration Hs biological process
BMP signaling pathway Hs biological process
embryonic genitalia morphogenesis Hs biological process
pancreas development Hs biological process
positive regulation of insulin secretion Hs biological process
positive regulation of protein binding Hs biological process
regulation of hormone metabolic process Hs biological process
negative regulation of interleukin-13 production Hs biological process
negative regulation of interleukin-4 production Hs biological process
negative regulation of interleukin-5 production Hs biological process
protein-DNA complex Hs cellular component
T cell receptor V(D)J recombination Hs biological process
nuclear hormone receptor binding Hs molecular function
enhancer binding Hs molecular function
B cell proliferation Hs biological process
regulation of cell proliferation Hs biological process
histone binding Hs molecular function
glucose homeostasis Hs biological process
histone deacetylase binding Hs molecular function
cysteine-type endopeptidase inhibitor activity involved in apoptotic process Hs molecular function
negative regulation of apoptotic process Hs biological process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Hs biological process
negative regulation of DNA binding Hs biological process
steroid hormone mediated signaling pathway Hs biological process
negative regulation of sequence-specific DNA binding transcription factor activity Hs biological process
sequence-specific DNA binding Hs molecular function
maintenance of DNA repeat elements Hs biological process
histone H3 acetylation Hs biological process
histone H4 acetylation Hs biological process
transcription regulatory region DNA binding Hs molecular function
gamma-catenin binding Hs molecular function
fat cell differentiation Hs biological process
negative regulation of striated muscle tissue development Hs biological process
negative regulation of transcription, DNA-templated Hs biological process
positive regulation of transcription, DNA-templated Hs biological process
positive regulation of transcription from RNA polymerase II promoter Hs biological process
alpha-beta T cell differentiation Hs biological process
positive regulation of protein export from nucleus Hs biological process
eye pigmentation Hs biological process
paraxial mesoderm formation Hs biological process
cell development Hs biological process
embryonic digestive tract morphogenesis Hs biological process
muscle fiber development Hs biological process
sensory perception of taste Hs biological process
positive regulation of protein kinase B signaling Hs biological process
palate development Hs biological process
anatomical structure regression Hs biological process
canonical Wnt signaling pathway Hs biological process
face morphogenesis Hs biological process
cell chemotaxis Hs biological process
apoptotic process involved in morphogenesis Hs biological process
trachea gland development Hs biological process
armadillo repeat domain binding Hs molecular function
beta-catenin-TCF7L2 complex Hs cellular component
C2H2 zinc finger domain binding Hs molecular function
positive regulation of cell proliferation in bone marrow Hs biological process
negative regulation of apoptotic process in bone marrow Hs biological process
odontoblast differentiation Hs biological process
negative regulation of canonical Wnt signaling pathway Hs biological process
apoptotic process involved in blood vessel morphogenesis Hs biological process
beta-catenin-TCF complex Hs cellular component
negative regulation of extrinsic apoptotic signaling pathway Hs biological process
cytosol Hs cellular component
chromatin organization Hs biological process

GO (Blast)

39 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae
Type Score E-value
nuclear chromatin Hs cellular component 201 2.27e-56
RNA polymerase II regulatory region sequence-specific DNA binding Hs molecular function 173 4.24e-48
RNA polymerase II core promoter proximal region sequence-specific DNA binding Hs molecular function 207 5.93e-60
RNA polymerase II transcription factor activity, sequence-specific DNA binding Hs molecular function 207 5.93e-60
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding Hs molecular function 173 4.24e-48
RNA polymerase II repressing transcription factor binding Hs molecular function 201 2.27e-56
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding Hs molecular function 207 5.93e-60
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding Hs molecular function 173 4.24e-48
DNA binding Hs molecular function 207 5.93e-60
chromatin binding Hs molecular function 173 4.24e-48
transcription factor activity, sequence-specific DNA binding Hs molecular function 207 5.93e-60
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Hs molecular function 173 4.24e-48
protein binding Hs molecular function 207 5.93e-60
nucleus Hs cellular component 207 5.93e-60
nucleoplasm Hs cellular component 207 5.93e-60
transcription factor complex Hs cellular component 207 5.93e-60
nuclear euchromatin Hs cellular component 207 5.93e-60
cytoplasm Hs cellular component 173 4.24e-48
beta-catenin binding Hs molecular function 207 5.93e-60
transcription factor binding Hs molecular function 201 2.27e-56
DNA binding, bending Hs molecular function 173 4.24e-48
nuclear body Hs cellular component 207 5.93e-60
PML body Hs cellular component 201 2.27e-56
protein kinase binding Hs molecular function 201 2.27e-56
estrogen receptor activity Hs molecular function 173 4.24e-48
estrogen receptor binding Hs molecular function 173 4.24e-48
protein-DNA complex Hs cellular component 201 2.27e-56
nuclear hormone receptor binding Hs molecular function 201 2.27e-56
enhancer binding Hs molecular function 173 4.24e-48
histone binding Hs molecular function 173 4.24e-48
histone deacetylase binding Hs molecular function 173 4.24e-48
cysteine-type endopeptidase inhibitor activity involved in apoptotic process Hs molecular function 173 4.24e-48
sequence-specific DNA binding Hs molecular function 207 5.93e-60
transcription regulatory region DNA binding Hs molecular function 207 5.93e-60
gamma-catenin binding Hs molecular function 201 2.27e-56
armadillo repeat domain binding Hs molecular function 201 2.27e-56
beta-catenin-TCF7L2 complex Hs cellular component 201 2.27e-56
C2H2 zinc finger domain binding Hs molecular function 173 4.24e-48
beta-catenin-TCF complex Hs cellular component 173 4.24e-48

GO (InterProScan)

No result

GO Term Analysis Type e-value