Aniseed - Gene card

Gene Card

Best human hits

SMAD1; SMAD2; SMAD3

Species

M.oculata

Unique Gene ID

Moocul.g00014337

Gene Model ID

Moocul.CG.ELv1_2.S122468.g14337

Location

S122468:16204..23699

Transcript Models and Sequences

Moocul.CG.ELv1_2.S122468.g14337.01.t

External Database Gene Card

External database links

No result

Collections

WashU Genome Browser

Click here to view results in the tunicate WashU Browser

Genomicus Synteny Browser

Regulatory Regions

No result

n/a

Gene Phylogeny

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Gene Annotations

InterPro

11 results

IPR Term	Analysis	Definition
SMAD_dom_Dwarfin-type	SMART	SMAD domain, Dwarfin-type
Dwarfin	PANTHER	Dwarfin
MAD_homology1_Dwarfin-type	SMART	MAD homology 1, Dwarfin-type
SMAD_dom_Dwarfin-type	ProSiteProfiles	SMAD domain, Dwarfin-type
SMAD_MH1_sf	SUPERFAMILY	SMAD MH1 domain superfamily
SMAD_MH1_sf	Gene3D	SMAD MH1 domain superfamily
MAD_homology_MH1	ProSiteProfiles	MAD homology, MH1
SMAD_FHA_dom_sf	SUPERFAMILY	SMAD/FHA domain superfamily
SMAD-like_dom_sf	Gene3D	SMAD-like domain superfamily
MAD_homology1_Dwarfin-type	Pfam	MAD homology 1, Dwarfin-type
SMAD_dom_Dwarfin-type	Pfam	SMAD domain, Dwarfin-type

GOSlim

No result

GO Term	Annotation Origin	Type

GO (Orthology)

145 results

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type
negative regulation of transcription from RNA polymerase II promoter	Hs	biological process
nuclear chromatin	Hs	cellular component
RNA polymerase II regulatory region sequence-specific DNA binding	Hs	molecular function
RNA polymerase II core promoter proximal region sequence-specific DNA binding	Hs	molecular function
RNA polymerase II transcription factor activity, sequence-specific DNA binding	Hs	molecular function
transcription factor activity, RNA polymerase II core promoter sequence-specific	Hs	molecular function
core promoter proximal region sequence-specific DNA binding	Hs	molecular function
transcription factor activity, transcription factor binding	Hs	molecular function
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	Hs	molecular function
RNA polymerase II activating transcription factor binding	Hs	molecular function
skeletal system development	Hs	biological process
osteoblast differentiation	Hs	biological process
ureteric bud development	Hs	biological process
response to hypoxia	Hs	biological process
endoderm formation	Hs	biological process
mesoderm formation	Hs	biological process
somitogenesis	Hs	biological process
liver development	Hs	biological process
heart looping	Hs	biological process
osteoblast development	Hs	biological process
DNA binding	Hs	molecular function
chromatin binding	Hs	molecular function
double-stranded DNA binding	Hs	molecular function
transcription factor activity, sequence-specific DNA binding	Hs	molecular function
transforming growth factor beta receptor binding	Hs	molecular function
protein binding	Hs	molecular function
collagen binding	Hs	molecular function
intracellular	Hs	cellular component
nucleus	Hs	cellular component
nuclear inner membrane	Hs	cellular component
nucleoplasm	Hs	cellular component
transcription factor complex	Hs	cellular component
cytoplasm	Hs	cellular component
cytosol	Hs	cellular component
plasma membrane	Hs	cellular component
transcription, DNA-templated	Hs	biological process
regulation of transcription, DNA-templated	Hs	biological process
regulation of transcription from RNA polymerase II promoter	Hs	biological process
transcription from RNA polymerase II promoter	Hs	biological process
protein phosphorylation	Hs	biological process
activation of cysteine-type endopeptidase activity involved in apoptotic process	Hs	biological process
immune response	Hs	biological process
cell cycle arrest	Hs	biological process
transforming growth factor beta receptor signaling pathway	Hs	biological process
gastrulation	Hs	biological process
pattern specification process	Hs	biological process
endoderm development	Hs	biological process
heart development	Hs	biological process
beta-catenin binding	Hs	molecular function
transcription factor binding	Hs	molecular function
zinc ion binding	Hs	molecular function
negative regulation of cell proliferation	Hs	biological process
response to glucose	Hs	biological process
post-embryonic development	Hs	biological process
embryonic pattern specification	Hs	biological process
anterior/posterior pattern specification	Hs	biological process
positive regulation of gene expression	Hs	biological process
negative regulation of gene expression	Hs	biological process
positive regulation of epithelial to mesenchymal transition	Hs	biological process
membrane	Hs	cellular component
integral component of membrane	Hs	cellular component
regulation of striated muscle tissue development	Hs	biological process
protein deubiquitination	Hs	biological process
regulation of transforming growth factor beta receptor signaling pathway	Hs	biological process
DEAD/H-box RNA helicase binding	Hs	molecular function
enzyme binding	Hs	molecular function
protein kinase binding	Hs	molecular function
phosphatase binding	Hs	molecular function
signal transduction involved in regulation of gene expression	Hs	biological process
insulin secretion	Hs	biological process
negative regulation of cell growth	Hs	biological process
lung development	Hs	biological process
positive regulation of cell migration	Hs	biological process
positive regulation of bone mineralization	Hs	biological process
negative regulation of transforming growth factor beta receptor signaling pathway	Hs	biological process
positive regulation of BMP signaling pathway	Hs	biological process
transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity	Hs	molecular function
thyroid gland development	Hs	biological process
pancreas development	Hs	biological process
primary miRNA processing	Hs	biological process
chromatin DNA binding	Hs	molecular function
ubiquitin protein ligase binding	Hs	molecular function
mineralocorticoid receptor binding	Hs	molecular function
positive regulation of chondrocyte differentiation	Hs	biological process
activin responsive factor complex	Hs	cellular component
activin receptor signaling pathway	Hs	biological process
macromolecular complex	Hs	cellular component
activating transcription factor binding	Hs	molecular function
negative regulation of osteoblast proliferation	Hs	biological process
type I transforming growth factor beta receptor binding	Hs	molecular function
somatic stem cell population maintenance	Hs	biological process
glucocorticoid receptor binding	Hs	molecular function
organ growth	Hs	biological process
enhancer binding	Hs	molecular function
intracellular signal transduction	Hs	biological process
nodal signaling pathway	Hs	biological process
wound healing	Hs	biological process
T cell activation	Hs	biological process
negative regulation of protein catabolic process	Hs	biological process
identical protein binding	Hs	molecular function
protein homodimerization activity	Hs	molecular function
positive regulation of transcription factor import into nucleus	Hs	biological process
negative regulation of apoptotic process	Hs	biological process
ubiquitin binding	Hs	molecular function
receptor complex	Hs	cellular component
bHLH transcription factor binding	Hs	molecular function
sequence-specific DNA binding	Hs	molecular function
transcription regulatory region DNA binding	Hs	molecular function
cell fate commitment	Hs	biological process
cell-cell junction organization	Hs	biological process
positive regulation of nitric oxide biosynthetic process	Hs	biological process
negative regulation of osteoblast differentiation	Hs	biological process
negative regulation of transcription, DNA-templated	Hs	biological process
positive regulation of transcription, DNA-templated	Hs	biological process
negative regulation of mitotic cell cycle	Hs	biological process
positive regulation of transcription from RNA polymerase II promoter	Hs	biological process
SMAD binding	Hs	molecular function
metal ion binding	Hs	molecular function
protein heterodimerization activity	Hs	molecular function
developmental growth	Hs	biological process
embryonic foregut morphogenesis	Hs	biological process
embryonic cranial skeleton morphogenesis	Hs	biological process
regulation of epithelial cell proliferation	Hs	biological process
negative regulation of inflammatory response	Hs	biological process
regulation of immune response	Hs	biological process
protein stabilization	Hs	biological process
positive regulation of positive chemotaxis	Hs	biological process
negative regulation of cytosolic calcium ion concentration	Hs	biological process
positive regulation of stress fiber assembly	Hs	biological process
positive regulation of focal adhesion assembly	Hs	biological process
palate development	Hs	biological process
canonical Wnt signaling pathway	Hs	biological process
transdifferentiation	Hs	biological process
SMAD protein signal transduction	Hs	biological process
lens fiber cell differentiation	Hs	biological process
co-SMAD binding	Hs	molecular function
I-SMAD binding	Hs	molecular function
R-SMAD binding	Hs	molecular function
primary miRNA binding	Hs	molecular function
SMAD protein complex	Hs	cellular component
SMAD2-SMAD3 protein complex	Hs	cellular component
cellular response to transforming growth factor beta stimulus	Hs	biological process
extrinsic apoptotic signaling pathway	Hs	biological process
disordered domain specific binding	Hs	molecular function
positive regulation of extracellular matrix assembly	Hs	biological process

GO (Blast)

61 results

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type	Score	E-value
nuclear chromatin	Hs	cellular component	587	0.0
RNA polymerase II regulatory region sequence-specific DNA binding	Hs	molecular function	587	0.0
RNA polymerase II core promoter proximal region sequence-specific DNA binding	Hs	molecular function	587	0.0
RNA polymerase II transcription factor activity, sequence-specific DNA binding	Hs	molecular function	587	0.0
transcription factor activity, RNA polymerase II core promoter sequence-specific	Hs	molecular function	587	0.0
core promoter proximal region sequence-specific DNA binding	Hs	molecular function	587	0.0
transcription factor activity, transcription factor binding	Hs	molecular function	587	0.0
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	Hs	molecular function	554	0.0
RNA polymerase II activating transcription factor binding	Hs	molecular function	587	0.0
DNA binding	Hs	molecular function	587	0.0
chromatin binding	Hs	molecular function	587	0.0
double-stranded DNA binding	Hs	molecular function	587	0.0
transcription factor activity, sequence-specific DNA binding	Hs	molecular function	587	0.0
signal transducer activity, downstream of receptor	Hs	molecular function	462	8.01e-162
transforming growth factor beta receptor binding	Hs	molecular function	587	0.0
protein binding	Hs	molecular function	587	0.0
collagen binding	Hs	molecular function	587	0.0
intracellular	Hs	cellular component	587	0.0
nucleus	Hs	cellular component	587	0.0
nuclear inner membrane	Hs	cellular component	587	0.0
nucleoplasm	Hs	cellular component	587	0.0
transcription factor complex	Hs	cellular component	587	0.0
cytoplasm	Hs	cellular component	587	0.0
cytosol	Hs	cellular component	587	0.0
plasma membrane	Hs	cellular component	587	0.0
beta-catenin binding	Hs	molecular function	587	0.0
transcription factor binding	Hs	molecular function	587	0.0
zinc ion binding	Hs	molecular function	587	0.0
membrane	Hs	cellular component	554	0.0
integral component of membrane	Hs	cellular component	554	0.0
DEAD/H-box RNA helicase binding	Hs	molecular function	587	0.0
enzyme binding	Hs	molecular function	587	0.0
protein kinase binding	Hs	molecular function	587	0.0
phosphatase binding	Hs	molecular function	587	0.0
transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity	Hs	molecular function	587	0.0
chromatin DNA binding	Hs	molecular function	587	0.0
ubiquitin protein ligase binding	Hs	molecular function	587	0.0
mineralocorticoid receptor binding	Hs	molecular function	587	0.0
activin responsive factor complex	Hs	cellular component	554	0.0
macromolecular complex	Hs	cellular component	554	0.0
activating transcription factor binding	Hs	molecular function	554	0.0
type I transforming growth factor beta receptor binding	Hs	molecular function	554	0.0
glucocorticoid receptor binding	Hs	molecular function	587	0.0
enhancer binding	Hs	molecular function	587	0.0
identical protein binding	Hs	molecular function	587	0.0
protein homodimerization activity	Hs	molecular function	587	0.0
ubiquitin binding	Hs	molecular function	587	0.0
receptor complex	Hs	cellular component	587	0.0
bHLH transcription factor binding	Hs	molecular function	587	0.0
sequence-specific DNA binding	Hs	molecular function	587	0.0
transcription regulatory region DNA binding	Hs	molecular function	587	0.0
SMAD binding	Hs	molecular function	587	0.0
metal ion binding	Hs	molecular function	587	0.0
protein heterodimerization activity	Hs	molecular function	587	0.0
co-SMAD binding	Hs	molecular function	587	0.0
I-SMAD binding	Hs	molecular function	554	0.0
R-SMAD binding	Hs	molecular function	587	0.0
primary miRNA binding	Hs	molecular function	587	0.0
SMAD protein complex	Hs	cellular component	587	0.0
SMAD2-SMAD3 protein complex	Hs	cellular component	587	0.0
disordered domain specific binding	Hs	molecular function	554	0.0

GO (InterProScan)

6 results

GO Term	Analysis	Type	e-value
transcription factor activity, sequence-specific DNA binding	ProSiteProfiles	molecular function	35.505
protein binding	SUPERFAMILY	molecular function	1.62E-78
intracellular	PANTHER	cellular component	7.7E-213
transcription factor complex	ProSiteProfiles	cellular component	35.505
regulation of transcription, DNA-templated	PANTHER	biological process	7.7E-213
transforming growth factor beta receptor signaling pathway	Gene3D	biological process	1.6E-63