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Gene Card

Best human hits

AC008695.1; RAPGEF2; RAPGEF6

Species

M.oculata

Unique Gene ID

Moocul.g00002995

Gene Model ID

Moocul.CG.ELv1_2.S51751.g02995

Location

S51751:24504..50438

Transcript Models and Sequences

  Moocul.CG.ELv1_2.S51751.g02995.01.t
Moocul.CG.ELv1_2.S51751.g02995.02.t

External Database Gene Card

External database links

No result

Collections
WashU Genome Browser

Click here to view results in the tunicate WashU Browser

Genomicus Synteny Browser

Genomicus browser link

Regulatory Regions

Regulatory Regions

No result

n/a

Gene Phylogeny

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Gene Annotations

InterPro

23 results

IPR Term Analysis Definition
Ras_GEF_dom_sf SUPERFAMILY Ras guanine nucleotide exchange factor domain superfamily
Ras-like_Gua-exchang_fac_N SMART Ras-like guanine nucleotide exchange factor, N-terminal
PDZ ProSiteProfiles PDZ domain
RA_dom Pfam Ras-associating (RA) domain
RA_dom SMART Ras-associating (RA) domain
Ras-like_Gua-exchang_fac_N Pfam Ras-like guanine nucleotide exchange factor, N-terminal
RmlC-like_jellyroll Gene3D RmlC-like jelly roll fold
RASGEF_cat_dom CDD Ras guanine-nucleotide exchange factors catalytic domain
cNMP-bd_dom CDD Cyclic nucleotide-binding domain
PDZ_sf SUPERFAMILY PDZ superfamily
RapGEF2 PANTHER Rap guanine nucleotide exchange factor 2
Ras-like_Gua-exchang_fac_N ProSiteProfiles Ras-like guanine nucleotide exchange factor, N-terminal
PDZ Pfam PDZ domain
cNMP-bd-like SUPERFAMILY Cyclic nucleotide-binding-like
RASGEF_cat_dom SMART Ras guanine-nucleotide exchange factors catalytic domain
Ras-like_Gua-exchang_fac_N CDD Ras-like guanine nucleotide exchange factor, N-terminal
RASGEF_cat_dom_sf Gene3D Ras guanine-nucleotide exchange factor catalytic domain superfamily
RASGEF_cat_dom Pfam Ras guanine-nucleotide exchange factors catalytic domain
RA_dom ProSiteProfiles Ras-associating (RA) domain
cNMP-bd_dom ProSiteProfiles Cyclic nucleotide-binding domain
PDZ SMART PDZ domain
cNMP-bd_dom SMART Cyclic nucleotide-binding domain
RASGEF_cat_dom ProSiteProfiles Ras guanine-nucleotide exchange factors catalytic domain

GOSlim

No result

GO Term Annotation Origin Type

GO (Orthology)

74 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type
MAPK cascade Hs biological process
blood vessel development Hs biological process
neuron migration Hs biological process
signal transducer activity Hs molecular function
guanyl-nucleotide exchange factor activity Hs molecular function
Ras guanyl-nucleotide exchange factor activity Hs molecular function
GTPase activator activity Hs molecular function
calcium ion binding Hs molecular function
protein binding Hs molecular function
intracellular Hs cellular component
cytoplasm Hs cellular component
endosome Hs cellular component
late endosome Hs cellular component
centrosome Hs cellular component
cytosol Hs cellular component
plasma membrane Hs cellular component
integral component of plasma membrane Hs cellular component
cell-cell junction Hs cellular component
bicellular tight junction Hs cellular component
signal transduction Hs biological process
G-protein coupled receptor signaling pathway Hs biological process
neuropeptide signaling pathway Hs biological process
small GTPase mediated signal transduction Hs biological process
Ras protein signal transduction Hs biological process
multicellular organism development Hs biological process
nervous system development Hs biological process
negative regulation of cell proliferation Hs biological process
positive regulation of neuron projection development Hs biological process
membrane Hs cellular component
apical plasma membrane Hs cellular component
Ras GTPase binding Hs molecular function
Rap guanyl-nucleotide exchange factor activity Hs molecular function
cAMP-mediated signaling Hs biological process
diacylglycerol binding Hs molecular function
ventricular system development Hs biological process
forebrain neuron development Hs biological process
microvillus assembly Hs biological process
cell junction Hs cellular component
endocytic vesicle Hs cellular component
cell differentiation Hs biological process
PDZ domain binding Hs molecular function
cAMP binding Hs molecular function
GTP-dependent protein binding Hs molecular function
neuron projection development Hs biological process
beta-1 adrenergic receptor binding Hs molecular function
positive regulation of protein binding Hs biological process
Rap protein signal transduction Hs biological process
macromolecular complex Hs cellular component
intracellular signal transduction Hs biological process
nerve growth factor signaling pathway Hs biological process
regulation of cell proliferation Hs biological process
neuron projection Hs cellular component
neuronal cell body Hs cellular component
regulation of GTPase activity Hs biological process
positive regulation of GTPase activity Hs biological process
positive regulation of cAMP-mediated signaling Hs biological process
synapse Hs cellular component
positive regulation of protein kinase activity Hs biological process
negative regulation of melanin biosynthetic process Hs biological process
regulation of synaptic plasticity Hs biological process
perinuclear region of cytoplasm Hs cellular component
WW domain binding Hs molecular function
negative regulation of dendrite morphogenesis Hs biological process
establishment of endothelial barrier Hs biological process
regulation of molecular function Hs biological process
phosphatidic acid binding Hs molecular function
positive regulation of ERK1 and ERK2 cascade Hs biological process
cellular response to cGMP Hs biological process
adenylate cyclase-activating adrenergic receptor signaling pathway Hs biological process
protein localization to plasma membrane Hs biological process
establishment of endothelial intestinal barrier Hs biological process
regulation of cell junction assembly Hs biological process
positive regulation of dendritic cell apoptotic process Hs biological process
positive regulation of neuron migration Hs biological process

GO (Blast)

34 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type Score E-value
signal transducer activity Hs molecular function 754 0.0
guanyl-nucleotide exchange factor activity Hs molecular function 812 0.0
Ras guanyl-nucleotide exchange factor activity Hs molecular function 754 0.0
GTPase activator activity Hs molecular function 754 0.0
calcium ion binding Hs molecular function 754 0.0
protein binding Hs molecular function 812 0.0
intracellular Hs cellular component 812 0.0
cytoplasm Hs cellular component 812 0.0
endosome Hs cellular component 754 0.0
late endosome Hs cellular component 754 0.0
centrosome Hs cellular component 812 0.0
cytosol Hs cellular component 812 0.0
plasma membrane Hs cellular component 812 0.0
integral component of plasma membrane Hs cellular component 754 0.0
cell-cell junction Hs cellular component 754 0.0
bicellular tight junction Hs cellular component 754 0.0
membrane Hs cellular component 812 0.0
apical plasma membrane Hs cellular component 812 0.0
Ras GTPase binding Hs molecular function 812 0.0
Rap guanyl-nucleotide exchange factor activity Hs molecular function 754 0.0
diacylglycerol binding Hs molecular function 754 0.0
cell junction Hs cellular component 754 0.0
endocytic vesicle Hs cellular component 812 0.0
PDZ domain binding Hs molecular function 754 0.0
cAMP binding Hs molecular function 754 0.0
GTP-dependent protein binding Hs molecular function 812 0.0
beta-1 adrenergic receptor binding Hs molecular function 754 0.0
macromolecular complex Hs cellular component 754 0.0
neuron projection Hs cellular component 754 0.0
neuronal cell body Hs cellular component 754 0.0
synapse Hs cellular component 754 0.0
perinuclear region of cytoplasm Hs cellular component 754 0.0
WW domain binding Hs molecular function 754 0.0
phosphatidic acid binding Hs molecular function 812 0.0

GO (InterProScan)

8 results

GO Term Analysis Type e-value
guanyl-nucleotide exchange factor activity SMART molecular function 4.3E-59
GTPase activator activity PANTHER molecular function 3.6E-266
protein binding SUPERFAMILY molecular function 2.13E-13
signal transduction SMART biological process 1.2E-7
small GTPase mediated signal transduction SMART biological process 4.3E-59
Rap guanyl-nucleotide exchange factor activity PANTHER molecular function 3.6E-266
regulation of cell proliferation PANTHER biological process 3.6E-266
positive regulation of GTPase activity PANTHER biological process 3.6E-266

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