Gene Card
Best human hits
CIT; ROCK1; ROCK2
Species
Unique Gene ID
Phfumi.g00003398
Gene Model ID
Phfumi.CG.MTP2014.S1195.g03398
Location
S1195:3613..15257
Transcript Models and Sequences
Phfumi.CG.MTP2014.S1195.g03398.01.t
Phfumi.CG.MTP2014.S1195.g03398.02.t
Phfumi.CG.MTP2014.S1195.g03398.03.t
n/a
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Click here to see the tree inference method
InterPro
10 results
| IPR Term | Analysis | Definition |
|---|---|---|
| Rho-bd_dom | Pfam | Rho binding domain |
| PH_domain | ProSiteProfiles | Pleckstrin homology domain |
| PH-like_dom_sf | Gene3D | PH-like domain superfamily |
| PE/DAG-bd | ProSiteProfiles | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain |
| PE/DAG-bd | SMART | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain |
| PH_domain | SMART | Pleckstrin homology domain |
| PE/DAG-bd | CDD | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain |
| ROCK1 | PANTHER | Rho-associated protein kinase 1 |
| PH_domain | Pfam | Pleckstrin homology domain |
| ROCK2 | PANTHER | Rho-associated protein kinase 2 |
GOSlim
41 results
| GO Term | Annotation Origin | Type |
|---|---|---|
| Golgi membrane | Blast | cellular component |
| nucleotide binding | Blast | molecular function |
| RNA binding | Blast | molecular function |
| protein kinase activity | Blast | molecular function |
| protein serine/threonine kinase activity | Blast | molecular function |
| structural molecule activity | Blast | molecular function |
| protein binding | Blast | molecular function |
| ATP binding | Blast | molecular function |
| extracellular region | Blast | cellular component |
| intracellular | Blast | cellular component |
| nucleus | Blast | cellular component |
| cytoplasm | Blast | cellular component |
| Golgi apparatus | Blast | cellular component |
| centrosome | Blast | cellular component |
| microtubule organizing center | Blast | cellular component |
| cytosol | Blast | cellular component |
| cytoskeleton | Blast | cellular component |
| plasma membrane | Blast | cellular component |
| membrane | Blast | cellular component |
| kinase activity | Blast | molecular function |
| transferase activity | Blast | molecular function |
| lamellipodium | Blast | cellular component |
| midbody | Blast | cellular component |
| intracellular signal transduction | InterProScan | biological process |
| cell projection | Blast | cellular component |
| neuronal cell body | Blast | cellular component |
| metal ion binding | Blast | molecular function |
| plasma membrane region | Blast | cellular component |
| cell leading edge | Blast | cellular component |
| cytoplasmic part | Blast | cellular component |
| enzyme binding | Blast | molecular function |
| Golgi apparatus part | Blast | cellular component |
| intracellular organelle part | Blast | cellular component |
| cytoplasmic vesicle | Blast | cellular component |
| endomembrane system | Blast | cellular component |
| intracellular organelle lumen | Blast | cellular component |
| intracellular non-membrane-bounded organelle | Blast | cellular component |
| macromolecular complex | Blast | cellular component |
| small GTPase mediated signal transduction | InterProScan | biological process |
| organelle organization | InterProScan | biological process |
| microtubule-based process | InterProScan | biological process |
| GO Term | SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae |
Type |
|---|
GO (Blast)
40 results
| GO Term | SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae |
Type | Score | E-value |
|---|---|---|---|---|
| Golgi membrane | Hs | cellular component | 411 | 9.06e-127 |
| nucleotide binding | Hs | molecular function | 471 | 9.11e-149 |
| ruffle | Hs | cellular component | 411 | 9.06e-127 |
| RNA binding | Hs | molecular function | 471 | 9.11e-149 |
| protein kinase activity | Hs | molecular function | 471 | 9.11e-149 |
| protein serine/threonine kinase activity | Hs | molecular function | 471 | 9.11e-149 |
| structural molecule activity | Hs | molecular function | 471 | 9.11e-149 |
| protein binding | Hs | molecular function | 471 | 9.11e-149 |
| ATP binding | Hs | molecular function | 471 | 9.11e-149 |
| extracellular region | Hs | cellular component | 411 | 9.06e-127 |
| intracellular | Hs | cellular component | 471 | 9.11e-149 |
| nucleus | Hs | cellular component | 471 | 9.11e-149 |
| cytoplasm | Hs | cellular component | 471 | 9.11e-149 |
| Golgi apparatus | Hs | cellular component | 411 | 9.06e-127 |
| centrosome | Hs | cellular component | 471 | 9.11e-149 |
| centriole | Hs | cellular component | 411 | 9.06e-127 |
| microtubule organizing center | Hs | cellular component | 471 | 9.11e-149 |
| cytosol | Hs | cellular component | 471 | 9.11e-149 |
| cytoskeleton | Hs | cellular component | 471 | 9.11e-149 |
| plasma membrane | Hs | cellular component | 471 | 9.11e-149 |
| membrane | Hs | cellular component | 471 | 9.11e-149 |
| kinase activity | Hs | molecular function | 471 | 9.11e-149 |
| transferase activity | Hs | molecular function | 471 | 9.11e-149 |
| Rho GTPase binding | Hs | molecular function | 471 | 9.11e-149 |
| GTP-Rho binding | Hs | molecular function | 471 | 9.11e-149 |
| SH3 domain binding | Hs | molecular function | 42.4 | 0.001 |
| lamellipodium | Hs | cellular component | 411 | 9.06e-127 |
| PDZ domain binding | Hs | molecular function | 42.4 | 0.001 |
| midbody | Hs | cellular component | 42.4 | 0.001 |
| Golgi cisterna | Hs | cellular component | 42.4 | 0.001 |
| bleb | Hs | cellular component | 411 | 9.06e-127 |
| cleavage furrow | Hs | cellular component | 42.4 | 0.001 |
| secretory granule lumen | Hs | cellular component | 411 | 9.06e-127 |
| cytoplasmic ribonucleoprotein granule | Hs | cellular component | 471 | 9.11e-149 |
| cell projection | Hs | cellular component | 411 | 9.06e-127 |
| neuronal cell body | Hs | cellular component | 42.4 | 0.001 |
| metal ion binding | Hs | molecular function | 471 | 9.11e-149 |
| Rho-dependent protein serine/threonine kinase activity | Hs | molecular function | 471 | 9.11e-149 |
| scaffold protein binding | Hs | molecular function | 42.4 | 0.001 |
| amyloid-beta complex | Hs | cellular component | 411 | 9.06e-127 |
GO (InterProScan)
11 results
| GO Term | Analysis | Type | e-value |
|---|---|---|---|
| protein serine/threonine kinase activity | PANTHER | molecular function | 1.2E-141 |
| smooth muscle contraction | PANTHER | biological process | 1.1E-159 |
| Rho protein signal transduction | PANTHER | biological process | 1.2E-141 |
| positive regulation of centrosome duplication | PANTHER | biological process | 1.1E-159 |
| Rho GTPase binding | Pfam | molecular function | 2.0E-17 |
| GTP-Rho binding | PANTHER | molecular function | 1.2E-141 |
| regulation of actin cytoskeleton organization | PANTHER | biological process | 1.1E-159 |
| intracellular signal transduction | CDD | biological process | 1.88778E-9 |
| regulation of stress fiber assembly | PANTHER | biological process | 1.2E-141 |
| regulation of cytoskeleton organization | PANTHER | biological process | 1.2E-141 |
| regulation of establishment of cell polarity | PANTHER | biological process | 1.2E-141 |
