Gene Card
Best human hits
NTRK1; ROR1; ROR2
Species
Unique Gene ID
Phfumi.g00006452
Gene Model ID
Phfumi.CG.MTP2014.S4586.g06452
Location
S4586:6257..12557
Transcript Models and Sequences
n/a
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The 'History' button on the left side permits you to see the changes you have made and eventually to go back.
You can Press 'Shift' Key + Left Mouse Click on the leaf's node to access to a gene card in a new window.
You can Press 'Ctrl' Key + Left Mouse Click on nodes to do a multiple selection.

IPR Term | Analysis | Definition |
---|---|---|
Ser-Thr/Tyr_kinase_cat_dom | PRINTS | Serine-threonine/tyrosine-protein kinase, catalytic domain |
Protein_kinase_ATP_BS | ProSitePatterns | Protein kinase, ATP binding site |
Ser-Thr/Tyr_kinase_cat_dom | Pfam | Serine-threonine/tyrosine-protein kinase, catalytic domain |
Tyr_kinase_AS | ProSitePatterns | Tyrosine-protein kinase, active site |
Kringle_CS | ProSitePatterns | Kringle, conserved site |
Frizzled_dom_sf | Gene3D | Frizzled cysteine-rich domain superfamily |
Tyr_kinase_cat_dom | SMART | Tyrosine-protein kinase, catalytic domain |
Kringle | CDD | Kringle |
Kringle | Pfam | Kringle |
Prot_kinase_dom | ProSiteProfiles | Protein kinase domain |
Kringle-like | SUPERFAMILY | Kringle-like fold |
Kinase-like_dom_sf | SUPERFAMILY | Protein kinase-like domain superfamily |
Kringle | SMART | Kringle |
Prot_kinase_dom | SMART | Protein kinase domain |
Kringle | ProSiteProfiles | Kringle |
Kringle_sf | Gene3D | Kringle superfamily |
Frizzled_dom | ProSiteProfiles | Frizzled domain |
GO Term | Annotation Origin | Type |
---|---|---|
nucleotide binding | Orthology | molecular function |
protein kinase activity | Orthology | molecular function |
protein binding | Orthology | molecular function |
ATP binding | Orthology | molecular function |
cytoplasm | Orthology | cellular component |
endosome | Blast | cellular component |
early endosome | Blast | cellular component |
microtubule | Orthology | cellular component |
plasma membrane | Orthology | cellular component |
integral component of plasma membrane | Orthology | cellular component |
protein phosphorylation | Orthology | biological process |
signal transduction | Orthology | biological process |
multicellular organism development | Orthology | biological process |
sensory perception of sound | Orthology | biological process |
negative regulation of cell proliferation | Orthology | biological process |
cell surface | Orthology | cellular component |
membrane | Orthology | cellular component |
integral component of membrane | Orthology | cellular component |
kinase activity | Orthology | molecular function |
phosphorylation | Orthology | biological process |
transferase activity | Orthology | molecular function |
kinase binding | Blast | molecular function |
cell differentiation | Orthology | biological process |
axon | Orthology | cellular component |
cytoplasmic vesicle | Orthology | cellular component |
macromolecular complex | Orthology | cellular component |
protein homodimerization activity | Blast | molecular function |
cell projection | Orthology | cellular component |
neuronal cell body | Orthology | cellular component |
positive regulation of transcription, DNA-templated | Orthology | biological process |
metal ion binding | Orthology | molecular function |
regulation of canonical Wnt signaling pathway | Orthology | biological process |
negative regulation of canonical Wnt signaling pathway | Orthology | biological process |
positive regulation of canonical Wnt signaling pathway | Orthology | biological process |
system development | Orthology | biological process |
animal organ development | Orthology | biological process |
anatomical structure morphogenesis | Orthology | biological process |
cytoskeletal part | Orthology | cellular component |
anatomical structure formation involved in morphogenesis | Orthology | biological process |
transmembrane signaling receptor activity | Orthology | molecular function |
receptor binding | Orthology | molecular function |
cell surface receptor signaling pathway | Orthology | biological process |
cell-cell signaling | Orthology | biological process |
cellular response to stress | Orthology | biological process |
intracellular signal transduction | Orthology | biological process |
cell development | Orthology | biological process |
neurogenesis | Orthology | biological process |
central nervous system development | Orthology | biological process |
cell migration | Orthology | biological process |
regulation of transcription from RNA polymerase II promoter | Orthology | biological process |
cellular response to organic substance | Orthology | biological process |
reproductive process | Orthology | biological process |
whole membrane | Orthology | cellular component |
intracellular organelle part | Orthology | cellular component |
bounding membrane of organelle | Orthology | cellular component |
transcription factor activity, sequence-specific DNA binding | Orthology | molecular function |
positive regulation of signal transduction | Orthology | biological process |
positive regulation of catalytic activity | Orthology | biological process |
protein serine/threonine kinase activity | Orthology | molecular function |
cell projection part | Orthology | cellular component |
synapse part | Orthology | cellular component |
chemical synaptic transmission | Orthology | biological process |
signaling receptor activity | Orthology | molecular function |
immune system process | Orthology | biological process |
GO Term | SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae |
Type | Score | E-value |
---|---|---|---|---|
nucleotide binding | Hs | molecular function | 396 | 6.19e-124 |
stress fiber | Hs | cellular component | 380 | 8.85e-118 |
protein kinase activity | Hs | molecular function | 396 | 6.19e-124 |
protein tyrosine kinase activity | Hs | molecular function | 396 | 6.19e-124 |
transmembrane receptor protein tyrosine kinase activity | Hs | molecular function | 396 | 6.19e-124 |
GPI-linked ephrin receptor activity | Hs | molecular function | 164 | 8.27e-42 |
neurotrophin receptor activity | Hs | molecular function | 164 | 8.27e-42 |
frizzled binding | Hs | molecular function | 396 | 6.19e-124 |
neurotrophin p75 receptor binding | Hs | molecular function | 164 | 8.27e-42 |
protein binding | Hs | molecular function | 396 | 6.19e-124 |
ATP binding | Hs | molecular function | 396 | 6.19e-124 |
cytoplasm | Hs | cellular component | 396 | 6.19e-124 |
endosome | Hs | cellular component | 164 | 8.27e-42 |
early endosome | Hs | cellular component | 164 | 8.27e-42 |
late endosome | Hs | cellular component | 164 | 8.27e-42 |
microtubule | Hs | cellular component | 396 | 6.19e-124 |
plasma membrane | Hs | cellular component | 396 | 6.19e-124 |
integral component of plasma membrane | Hs | cellular component | 396 | 6.19e-124 |
cell surface | Hs | cellular component | 396 | 6.19e-124 |
nerve growth factor receptor activity | Hs | molecular function | 164 | 8.27e-42 |
membrane | Hs | cellular component | 396 | 6.19e-124 |
integral component of membrane | Hs | cellular component | 396 | 6.19e-124 |
kinase activity | Hs | molecular function | 396 | 6.19e-124 |
transferase activity | Hs | molecular function | 396 | 6.19e-124 |
Wnt-protein binding | Hs | molecular function | 396 | 6.19e-124 |
kinase binding | Hs | molecular function | 164 | 8.27e-42 |
axon | Hs | cellular component | 380 | 8.85e-118 |
dendrite | Hs | cellular component | 396 | 6.19e-124 |
clathrin-coated endocytic vesicle membrane | Hs | cellular component | 396 | 6.19e-124 |
cytoplasmic vesicle | Hs | cellular component | 164 | 8.27e-42 |
early endosome membrane | Hs | cellular component | 164 | 8.27e-42 |
late endosome membrane | Hs | cellular component | 164 | 8.27e-42 |
macromolecular complex | Hs | cellular component | 164 | 8.27e-42 |
protein homodimerization activity | Hs | molecular function | 164 | 8.27e-42 |
Wnt-activated receptor activity | Hs | molecular function | 380 | 8.85e-118 |
cell projection | Hs | cellular component | 380 | 8.85e-118 |
neuronal cell body | Hs | cellular component | 396 | 6.19e-124 |
neurotrophin binding | Hs | molecular function | 164 | 8.27e-42 |
receptor complex | Hs | cellular component | 380 | 8.85e-118 |
axon terminus | Hs | cellular component | 380 | 8.85e-118 |
metal ion binding | Hs | molecular function | 396 | 6.19e-124 |
nerve growth factor binding | Hs | molecular function | 164 | 8.27e-42 |
coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway | Hs | molecular function | 396 | 6.19e-124 |
GO Term | Analysis | Type | e-value |
---|---|---|---|
protein kinase activity | Pfam | molecular function | 1.5E-54 |
protein tyrosine kinase activity | SMART | molecular function | 3.4E-66 |
protein binding | Gene3D | molecular function | 9.0E-21 |
ATP binding | SMART | molecular function | 1.9E-12 |
protein phosphorylation | SMART | biological process | 3.4E-66 |