IPR Term	Analysis	Definition
3'-5'_exonuclease_dom	SMART	3'-5' exonuclease domain
HRDC_dom	Pfam	HRDC domain
HRDC-like_sf	SUPERFAMILY	HRDC-like superfamily
RNaseH-like_sf	SUPERFAMILY	Ribonuclease H-like superfamily
HRDC_dom	SMART	HRDC domain
Exosome-assoc_fac_Rrp6_N	Pfam	Exosome-associated factor Rrp6, N-terminal
HRDC_dom	ProSiteProfiles	HRDC domain
3'-5'_exonuclease_dom	Pfam	3'-5' exonuclease domain

GO Term	Annotation Origin	Type
nucleotide binding	Orthology	molecular function
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	Orthology	biological process
nuclear-transcribed mRNA catabolic process	Orthology	biological process
nucleic acid binding	Orthology	molecular function
RNA binding	Orthology	molecular function
catalytic activity	Orthology	molecular function
protein binding	Orthology	molecular function
intracellular	Orthology	cellular component
nucleus	Orthology	cellular component
nucleoplasm	Orthology	cellular component
nucleolus	Orthology	cellular component
cytoplasm	Orthology	cellular component
cytosol	Orthology	cellular component
nucleobase-containing compound metabolic process	Orthology	biological process
RNA processing	Orthology	biological process
membrane	Orthology	cellular component
hydrolase activity	Orthology	molecular function
protein homodimerization activity	Blast	molecular function
cellular metabolic process	Orthology	biological process
metal ion binding	Blast	molecular function
RNA metabolic process	Orthology	biological process
nuclear lumen	Orthology	cellular component
macromolecular complex	Orthology	cellular component
intracellular part	Orthology	cellular component
organelle organization	Orthology	biological process
DNA metabolic process	Orthology	biological process
transferase activity, transferring phosphorus-containing groups	Orthology	molecular function
intracellular organelle part	Orthology	cellular component
intracellular non-membrane-bounded organelle	Orthology	cellular component
RNA catabolic process	Orthology	biological process
mRNA processing	Orthology	biological process
cytoplasmic part	Blast	cellular component

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type
nucleotide binding	Hs	molecular function
3'-5'-exoribonuclease activity	Hs	molecular function
nuclear exosome (RNase complex)	Hs	cellular component
exosome (RNase complex)	Hs	cellular component
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	Hs	biological process
maturation of 5.8S rRNA	Hs	biological process
nuclear-transcribed mRNA catabolic process	Hs	biological process
nucleic acid binding	Hs	molecular function
RNA binding	Hs	molecular function
catalytic activity	Hs	molecular function
nuclease activity	Hs	molecular function
exonuclease activity	Hs	molecular function
exoribonuclease activity	Hs	molecular function
protein binding	Hs	molecular function
intracellular	Hs	cellular component
nucleus	Hs	cellular component
nucleoplasm	Hs	cellular component
nucleolus	Hs	cellular component
cytoplasm	Hs	cellular component
cytosol	Hs	cellular component
nucleobase-containing compound metabolic process	Hs	biological process
rRNA processing	Hs	biological process
RNA processing	Hs	biological process
3'-5' exonuclease activity	Hs	molecular function
membrane	Hs	cellular component
hydrolase activity	Hs	molecular function
negative regulation of telomere maintenance via telomerase	Hs	biological process
transcriptionally active chromatin	Hs	cellular component
cellular metabolic process	Hs	biological process
telomerase RNA binding	Hs	molecular function
nuclear mRNA surveillance	Hs	biological process
CUT catabolic process	Hs	biological process
nuclear polyadenylation-dependent rRNA catabolic process	Hs	biological process
nuclear retention of unspliced pre-mRNA at the site of transcription	Hs	biological process
nucleic acid phosphodiester bond hydrolysis	Hs	biological process
RNA phosphodiester bond hydrolysis, exonucleolytic	Hs	biological process

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type	Score	E-value
nucleotide binding	Hs	molecular function	567	0.0
3'-5'-exoribonuclease activity	Hs	molecular function	567	0.0
nuclear exosome (RNase complex)	Hs	cellular component	567	0.0
exosome (RNase complex)	Hs	cellular component	567	0.0
nucleic acid binding	Hs	molecular function	567	0.0
RNA binding	Hs	molecular function	567	0.0
catalytic activity	Hs	molecular function	567	0.0
nuclease activity	Hs	molecular function	567	0.0
exonuclease activity	Hs	molecular function	567	0.0
exoribonuclease activity	Hs	molecular function	567	0.0
protein binding	Hs	molecular function	567	0.0
intracellular	Hs	cellular component	567	0.0
nucleus	Hs	cellular component	567	0.0
nucleoplasm	Hs	cellular component	567	0.0
nucleolus	Hs	cellular component	567	0.0
cytoplasm	Hs	cellular component	567	0.0
cytosol	Hs	cellular component	567	0.0
3'-5' exonuclease activity	Hs	molecular function	567	0.0
membrane	Hs	cellular component	567	0.0
hydrolase activity	Hs	molecular function	567	0.0
transcriptionally active chromatin	Hs	cellular component	567	0.0
protein homodimerization activity	Hs	molecular function	41.6	0.002
P granule	Hs	cellular component	41.6	0.002
metal ion binding	Hs	molecular function	43.1	6.43e-04
telomerase RNA binding	Hs	molecular function	567	0.0
PET complex	Hs	cellular component	41.6	0.002

GO Term	Analysis	Type	e-value
nucleotide binding	SUPERFAMILY	molecular function	1.44E-23
nuclear exosome (RNase complex)	Pfam	cellular component	3.7E-14
nucleic acid binding	Pfam	molecular function	2.3E-46
catalytic activity	SUPERFAMILY	molecular function	1.44E-23
intracellular	SMART	cellular component	1.1E-13
nucleobase-containing compound metabolic process	Pfam	biological process	2.3E-46
RNA processing	Pfam	biological process	3.7E-14
3'-5' exonuclease activity	Pfam	molecular function	2.3E-46
cellular metabolic process	SUPERFAMILY	biological process	1.44E-23