IPR Term	Analysis	Definition
HLH_DNA-bd_sf	SUPERFAMILY	Helix-loop-helix DNA-binding domain superfamily
HLH_DNA-bd_sf	Gene3D	Helix-loop-helix DNA-binding domain superfamily

GO Term	Annotation Origin	Type
protein dimerization activity	Orthology	molecular function
negative regulation of transcription from RNA polymerase II promoter	Orthology	biological process
RNA polymerase II transcription factor activity, sequence-specific DNA binding	Orthology	molecular function
angiogenesis	Orthology	biological process
transcription factor activity, sequence-specific DNA binding	Orthology	molecular function
transcription corepressor activity	Orthology	molecular function
protein binding	Orthology	molecular function
nucleus	Orthology	cellular component
nucleoplasm	Orthology	cellular component
cytoplasm	Orthology	cellular component
Golgi apparatus	Orthology	cellular component
centrosome	Orthology	cellular component
cytosol	Orthology	cellular component
transcription, DNA-templated	Orthology	biological process
regulation of transcription, DNA-templated	Orthology	biological process
multicellular organism development	Orthology	biological process
central nervous system development	Orthology	biological process
brain development	Orthology	biological process
heart development	Orthology	biological process
protein C-terminus binding	Orthology	molecular function
transcription factor binding	Orthology	molecular function
response to wounding	Orthology	biological process
positive regulation of gene expression	Orthology	biological process
negative regulation of gene expression	Orthology	biological process
neuron differentiation	Orthology	biological process
macromolecular complex	Orthology	cellular component
protein homodimerization activity	Orthology	molecular function
positive regulation of apoptotic process	Orthology	biological process
negative regulation of apoptotic process	Orthology	biological process
negative regulation of transcription, DNA-templated	Orthology	biological process
positive regulation of transcription, DNA-templated	Orthology	biological process
protein N-terminus binding	Orthology	molecular function
cell development	Orthology	biological process
blood vessel morphogenesis	Orthology	biological process
cell morphogenesis involved in neuron differentiation	Orthology	biological process
immune system process	Orthology	biological process
animal organ development	Orthology	biological process
cell differentiation	Orthology	biological process
DNA replication	Orthology	biological process
cell surface receptor signaling pathway	Orthology	biological process
cellular response to organic substance	Orthology	biological process
neurogenesis	Orthology	biological process
response to organic substance	Orthology	biological process
organic substance metabolic process	Orthology	biological process
regulation of transcription from RNA polymerase II promoter	Orthology	biological process
anatomical structure development	Orthology	biological process
regulation of molecular function	Orthology	biological process
organelle organization	Orthology	biological process
regulation of gene expression	Orthology	biological process
metabolic process	Orthology	biological process
anatomical structure morphogenesis	Orthology	biological process
DNA binding	Orthology	molecular function
intracellular signal transduction	Orthology	biological process
regulation of signal transduction	Orthology	biological process
regulation of cellular metabolic process	Orthology	biological process
protein phosphorylation	Orthology	biological process
cell migration	Orthology	biological process
positive regulation of cell proliferation	Orthology	biological process
neuron projection morphogenesis	Orthology	biological process
cell cycle	Orthology	biological process
system development	Orthology	biological process
macromolecular complex binding	Orthology	molecular function
cellular response to stress	Orthology	biological process
small molecule binding	Orthology	molecular function
anion binding	Orthology	molecular function
heterocyclic compound binding	Orthology	molecular function
organic cyclic compound binding	Orthology	molecular function
RNA polymerase II regulatory region sequence-specific DNA binding	Orthology	molecular function
G1/S transition of mitotic cell cycle	Orthology	biological process
negative regulation of cell proliferation	Orthology	biological process

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type
protein dimerization activity	Hs	molecular function
negative regulation of transcription from RNA polymerase II promoter	Hs	biological process
RNA polymerase II transcription factor activity, sequence-specific DNA binding	Hs	molecular function
angiogenesis	Hs	biological process
natural killer cell differentiation	Hs	biological process
thigmotaxis	Hs	biological process
leukocyte differentiation	Hs	biological process
transcription factor activity, sequence-specific DNA binding	Hs	molecular function
transcription corepressor activity	Hs	molecular function
protein binding	Hs	molecular function
nucleus	Hs	cellular component
nucleoplasm	Hs	cellular component
cytoplasm	Hs	cellular component
Golgi apparatus	Hs	cellular component
centrosome	Hs	cellular component
cytosol	Hs	cellular component
regulation of DNA replication	Hs	biological process
transcription, DNA-templated	Hs	biological process
regulation of transcription, DNA-templated	Hs	biological process
transforming growth factor beta receptor signaling pathway	Hs	biological process
multicellular organism development	Hs	biological process
central nervous system development	Hs	biological process
brain development	Hs	biological process
heart development	Hs	biological process
muscle organ development	Hs	biological process
circadian rhythm	Hs	biological process
protein C-terminus binding	Hs	molecular function
transcription factor binding	Hs	molecular function
adult locomotory behavior	Hs	biological process
response to wounding	Hs	biological process
entrainment of circadian clock	Hs	biological process
positive regulation of gene expression	Hs	biological process
negative regulation of gene expression	Hs	biological process
oligodendrocyte development	Hs	biological process
response to organic cyclic compound	Hs	biological process
regulation of lipid metabolic process	Hs	biological process
protein domain specific binding	Hs	molecular function
olfactory bulb development	Hs	biological process
neuron differentiation	Hs	biological process
BMP signaling pathway	Hs	biological process
epithelial cell differentiation	Hs	biological process
notochord development	Hs	biological process
protein destabilization	Hs	biological process
negative regulation of protein binding	Hs	biological process
positive regulation of actin filament bundle assembly	Hs	biological process
circadian regulation of gene expression	Hs	biological process
collagen metabolic process	Hs	biological process
macromolecular complex	Hs	cellular component
odontogenesis	Hs	biological process
regulation of circadian rhythm	Hs	biological process
protein homodimerization activity	Hs	molecular function
positive regulation of apoptotic process	Hs	biological process
negative regulation of apoptotic process	Hs	biological process
entrainment of circadian clock by photoperiod	Hs	biological process
negative regulation of DNA binding	Hs	biological process
regulation of MAPK cascade	Hs	biological process
negative regulation of sequence-specific DNA binding transcription factor activity	Hs	biological process
blood vessel endothelial cell migration	Hs	biological process
protein self-association	Hs	molecular function
ion channel binding	Hs	molecular function
locomotor rhythm	Hs	biological process
positive regulation of fat cell differentiation	Hs	biological process
positive regulation of erythrocyte differentiation	Hs	biological process
negative regulation of neuron differentiation	Hs	biological process
negative regulation of osteoblast differentiation	Hs	biological process
regulation of angiogenesis	Hs	biological process
positive regulation of blood pressure	Hs	biological process
negative regulation of transcription, DNA-templated	Hs	biological process
positive regulation of transcription, DNA-templated	Hs	biological process
response to antibiotic	Hs	biological process
protein N-terminus binding	Hs	molecular function
cell development	Hs	biological process
rhythmic process	Hs	biological process
blood vessel morphogenesis	Hs	biological process
embryonic digestive tract morphogenesis	Hs	biological process
neuron fate commitment	Hs	biological process
cell morphogenesis involved in neuron differentiation	Hs	biological process
positive regulation of epithelial cell proliferation	Hs	biological process
negative regulation of dendrite morphogenesis	Hs	biological process
regulation of cell cycle	Hs	biological process
adipose tissue development	Hs	biological process
endodermal digestive tract morphogenesis	Hs	biological process
proteasome binding	Hs	molecular function
positive regulation of cell cycle arrest	Hs	biological process
cellular response to epidermal growth factor stimulus	Hs	biological process
cellular response to transforming growth factor beta stimulus	Hs	biological process
cellular senescence	Hs	biological process
leptomycin B binding	Hs	molecular function
negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding	Hs	biological process
cellular response to dopamine	Hs	biological process
regulation of G1/S transition of mitotic cell cycle	Hs	biological process
negative regulation of neural precursor cell proliferation	Hs	biological process

GO Term	Analysis	Type	e-value
protein dimerization activity	Gene3D	molecular function	1.9E-5