Aniseed - Gene card

Gene Card

Best human hits

NPC1; PTCH1; PTCH2

Species

P.mammillata

Unique Gene ID

Phmamm.g00003321

Gene Model ID

Phmamm.CG.MTP2014.S106.g03321

Location

S106:59487..80735

Transcript Models and Sequences

Phmamm.CG.MTP2014.S106.g03321.01.t

External Database Gene Card

External database links

No result

Collections

Genoscope Yasuo Villefranche

4 results

AHC0AAA253YJ11

Plate: Plate_253_J11

WashU Genome Browser

Click here to view results in the tunicate WashU Browser

Genomicus Synteny Browser

Regulatory Regions

No result

n/a

Gene Phylogeny

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Gene Annotations

InterPro

3 results

IPR Term	Analysis	Definition
TM_rcpt_patched	TIGRFAM	Transmembrane receptor, patched
Ptc/Disp	Pfam	Protein patched/dispatched
SSD	ProSiteProfiles	Sterol-sensing domain

GOSlim

73 results

GO Term	Annotation Origin	Type
negative regulation of transcription from RNA polymerase II promoter	Orthology	biological process
transmembrane signaling receptor activity	Orthology	molecular function
protein binding	Orthology	molecular function
extracellular region	Blast	cellular component
nucleus	Orthology	cellular component
nuclear envelope	Blast	cellular component
lysosome	Blast	cellular component
lysosomal membrane	Blast	cellular component
endosome	Blast	cellular component
endoplasmic reticulum	Blast	cellular component
Golgi apparatus	Orthology	cellular component
plasma membrane	Orthology	cellular component
integral component of plasma membrane	Blast	cellular component
signal transduction	Orthology	biological process
brain development	Orthology	biological process
negative regulation of cell proliferation	Orthology	biological process
membrane	Orthology	cellular component
integral component of membrane	Orthology	cellular component
midbody	Orthology	cellular component
vesicle	Blast	cellular component
regulation of cell proliferation	Orthology	biological process
intracellular membrane-bounded organelle	Orthology	cellular component
macromolecular complex binding	Orthology	molecular function
membrane raft	Orthology	cellular component
negative regulation of transcription, DNA-templated	Orthology	biological process
positive regulation of transcription, DNA-templated	Orthology	biological process
perinuclear region of cytoplasm	Orthology	cellular component
extracellular exosome	Blast	cellular component
anatomical structure morphogenesis	Orthology	biological process
animal organ development	Orthology	biological process
cell differentiation	Orthology	biological process
anatomical structure formation involved in morphogenesis	Orthology	biological process
nervous system development	Orthology	biological process
heart development	Orthology	biological process
receptor binding	Orthology	molecular function
plasma membrane region	Orthology	cellular component
organelle	Orthology	cellular component
cell projection	Orthology	cellular component
macromolecular complex	Orthology	cellular component
cell surface receptor signaling pathway	Orthology	biological process
multicellular organism development	Orthology	biological process
anion binding	Orthology	molecular function
carbohydrate derivative binding	Orthology	molecular function
anatomical structure development	Orthology	biological process
regulation of signal transduction	Orthology	biological process
postsynapse	Orthology	cellular component
neuron part	Orthology	cellular component
response to organic substance	Orthology	biological process
small molecule binding	Orthology	molecular function
organic cyclic compound binding	Orthology	molecular function
gene expression	Orthology	biological process
proteolysis	Orthology	biological process
neuron differentiation	Orthology	biological process
central nervous system development	Orthology	biological process
intracellular organelle part	Orthology	cellular component
whole membrane	Orthology	cellular component
cytoplasmic vesicle	Orthology	cellular component
bounding membrane of organelle	Orthology	cellular component
response to lipid	Orthology	biological process
protein localization	Orthology	biological process
developmental process	Orthology	biological process
regulation of molecular function	Orthology	biological process
transcription factor activity, sequence-specific DNA binding	Orthology	molecular function
axon	Orthology	cellular component
cell projection part	Orthology	cellular component
negative regulation of signal transduction	Orthology	biological process
cell division	Orthology	biological process
system development	Orthology	biological process
cell projection membrane	Orthology	cellular component
axon guidance	Orthology	biological process
protein localization to membrane	Orthology	biological process
binding	Blast	molecular function
organic substance transport	Blast	biological process

GO (Orthology)

71 results

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type
negative regulation of transcription from RNA polymerase II promoter	Hs	biological process
branching involved in ureteric bud morphogenesis	Hs	biological process
cell fate determination	Hs	biological process
neural tube formation	Hs	biological process
neural tube closure	Hs	biological process
heart morphogenesis	Hs	biological process
patched binding	Hs	molecular function
smoothened binding	Hs	molecular function
protein binding	Hs	molecular function
nucleus	Hs	cellular component
Golgi apparatus	Hs	cellular component
plasma membrane	Hs	cellular component
caveola	Hs	cellular component
cilium	Hs	cellular component
signal transduction	Hs	biological process
smoothened signaling pathway	Hs	biological process
regulation of mitotic cell cycle	Hs	biological process
pattern specification process	Hs	biological process
brain development	Hs	biological process
hedgehog receptor activity	Hs	molecular function
heparin binding	Hs	molecular function
negative regulation of cell proliferation	Hs	biological process
epidermis development	Hs	biological process
regulation of smoothened signaling pathway	Hs	biological process
response to mechanical stimulus	Hs	biological process
animal organ morphogenesis	Hs	biological process
dorsal/ventral pattern formation	Hs	biological process
epidermal cell fate specification	Hs	biological process
response to chlorate	Hs	biological process
postsynaptic density	Hs	cellular component
response to organic cyclic compound	Hs	biological process
cholesterol binding	Hs	molecular function
membrane	Hs	cellular component
integral component of membrane	Hs	cellular component
protein processing	Hs	biological process
spinal cord motor neuron differentiation	Hs	biological process
neural tube patterning	Hs	biological process
embryonic limb morphogenesis	Hs	biological process
cyclin binding	Hs	molecular function
midbody	Hs	cellular component
endocytic vesicle membrane	Hs	cellular component
response to estradiol	Hs	biological process
response to retinoic acid	Hs	biological process
regulation of protein localization	Hs	biological process
limb morphogenesis	Hs	biological process
regulation of growth	Hs	biological process
negative regulation of multicellular organism growth	Hs	biological process
regulation of cell proliferation	Hs	biological process
response to drug	Hs	biological process
glucose homeostasis	Hs	biological process
intracellular membrane-bounded organelle	Hs	cellular component
negative regulation of sequence-specific DNA binding transcription factor activity	Hs	biological process
skin development	Hs	biological process
dendritic growth cone	Hs	cellular component
axonal growth cone	Hs	cellular component
macromolecular complex binding	Hs	molecular function
negative regulation of osteoblast differentiation	Hs	biological process
negative regulation of smoothened signaling pathway	Hs	biological process
negative regulation of transcription, DNA-templated	Hs	biological process
positive regulation of transcription, DNA-templated	Hs	biological process
perinuclear region of cytoplasm	Hs	cellular component
embryonic organ development	Hs	biological process
negative regulation of epithelial cell proliferation	Hs	biological process
negative regulation of cell division	Hs	biological process
pharyngeal system development	Hs	biological process
ciliary membrane	Hs	cellular component
somite development	Hs	biological process
commissural neuron axon guidance	Hs	biological process
renal system development	Hs	biological process
protein localization to plasma membrane	Hs	biological process
hedgehog family protein binding	Hs	molecular function

GO (Blast)

40 results

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type	Score	E-value
virus receptor activity	Hs	molecular function	116	8.12e-26
receptor activity	Hs	molecular function	116	8.12e-26
transmembrane signaling receptor activity	Hs	molecular function	116	8.12e-26
patched binding	Hs	molecular function	557	4.88e-170
smoothened binding	Hs	molecular function	557	4.88e-170
lipid transporter activity	Hs	molecular function	116	8.12e-26
protein binding	Hs	molecular function	557	4.88e-170
extracellular region	Hs	cellular component	116	8.12e-26
nucleus	Hs	cellular component	557	4.88e-170
nuclear envelope	Hs	cellular component	116	8.12e-26
lysosome	Hs	cellular component	116	8.12e-26
lysosomal membrane	Hs	cellular component	116	8.12e-26
endosome	Hs	cellular component	116	8.12e-26
endoplasmic reticulum	Hs	cellular component	116	8.12e-26
Golgi apparatus	Hs	cellular component	557	4.88e-170
plasma membrane	Hs	cellular component	557	4.88e-170
integral component of plasma membrane	Hs	cellular component	116	8.12e-26
caveola	Hs	cellular component	557	4.88e-170
cilium	Hs	cellular component	557	4.88e-170
hedgehog receptor activity	Hs	molecular function	557	4.88e-170
heparin binding	Hs	molecular function	557	4.88e-170
postsynaptic density	Hs	cellular component	557	4.88e-170
sterol transporter activity	Hs	molecular function	116	8.12e-26
cholesterol binding	Hs	molecular function	557	4.88e-170
membrane	Hs	cellular component	557	4.88e-170
integral component of membrane	Hs	cellular component	557	4.88e-170
cyclin binding	Hs	molecular function	557	4.88e-170
midbody	Hs	cellular component	557	4.88e-170
endocytic vesicle membrane	Hs	cellular component	557	4.88e-170
late endosome membrane	Hs	cellular component	116	8.12e-26
vesicle	Hs	cellular component	116	8.12e-26
intracellular membrane-bounded organelle	Hs	cellular component	557	4.88e-170
dendritic growth cone	Hs	cellular component	557	4.88e-170
axonal growth cone	Hs	cellular component	557	4.88e-170
macromolecular complex binding	Hs	molecular function	557	4.88e-170
membrane raft	Hs	cellular component	116	8.12e-26
perinuclear region of cytoplasm	Hs	cellular component	557	4.88e-170
ciliary membrane	Hs	cellular component	557	4.88e-170
extracellular exosome	Hs	cellular component	116	8.12e-26
hedgehog family protein binding	Hs	molecular function	557	4.88e-170

GO (InterProScan)

2 results

GO Term	Analysis	Type	e-value
hedgehog receptor activity	TIGRFAM	molecular function	0.0
integral component of membrane	TIGRFAM	cellular component	0.0