IPR Term	Analysis	Definition
WD40_repeat_CS	ProSitePatterns	WD40 repeat, conserved site
Znf-RING_LisH	Pfam	RING-type zinc-finger, LisH dimerisation motif
G-protein_beta_WD-40_rep	PRINTS	G-protein beta WD-40 repeat
Znf_TRAF	ProSiteProfiles	Zinc finger, TRAF-type
WD40_repeat	ProSiteProfiles	WD40 repeat
WD40_repeat	SMART	WD40 repeat
Znf_RING	ProSiteProfiles	Zinc finger, RING-type
WD40/YVTN_repeat-like_dom_sf	Gene3D	WD40/YVTN repeat-like-containing domain superfamily
Znf_RING/FYVE/PHD	Gene3D	Zinc finger, RING/FYVE/PHD-type
WD40_repeat	Pfam	WD40 repeat
WD40_repeat_dom_sf	SUPERFAMILY	WD40-repeat-containing domain superfamily
TRAF-like	SUPERFAMILY	TRAF-like
Znf_RING	SMART	Zinc finger, RING-type
WD40_repeat_dom	ProSiteProfiles	WD40-repeat-containing domain

GO Term	Annotation Origin	Type
ubiquitin-protein transferase activity	Orthology	molecular function
protein binding	Orthology	molecular function
nucleus	Blast	cellular component
nucleoplasm	Blast	cellular component
nucleolus	Blast	cellular component
cytoplasm	Blast	cellular component
centrosome	Blast	cellular component
cytosol	Blast	cellular component
plasma membrane	Orthology	cellular component
transcription, DNA-templated	Orthology	biological process
regulation of transcription, DNA-templated	Orthology	biological process
apoptotic process	Orthology	biological process
zinc ion binding	Orthology	molecular function
protein ubiquitination	Orthology	biological process
transferase activity	Orthology	molecular function
cytoplasmic vesicle	Orthology	cellular component
ubiquitin protein ligase binding	Blast	molecular function
identical protein binding	Blast	molecular function
intracellular membrane-bounded organelle	Orthology	cellular component
metal ion binding	Orthology	molecular function
protein dimerization activity	Blast	molecular function
intracellular part	Orthology	cellular component
macromolecular complex	Orthology	cellular component
positive regulation of catalytic activity	Orthology	biological process
intracellular signal transduction	Orthology	biological process
protein serine/threonine kinase activity	Orthology	molecular function
positive regulation of signal transduction	Orthology	biological process
protein phosphorylation	Orthology	biological process
positive regulation of apoptotic process	Orthology	biological process
enzyme regulator activity	Blast	molecular function

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type
ubiquitin ligase complex	Hs	cellular component
activation of MAPKKK activity	Hs	biological process
ubiquitin-protein transferase activity	Hs	molecular function
protein binding	Hs	molecular function
plasma membrane	Hs	cellular component
transcription, DNA-templated	Hs	biological process
regulation of transcription, DNA-templated	Hs	biological process
apoptotic process	Hs	biological process
zinc ion binding	Hs	molecular function
protein ubiquitination	Hs	biological process
transferase activity	Hs	molecular function
cytoplasmic vesicle	Hs	cellular component
intracellular membrane-bounded organelle	Hs	cellular component
positive regulation of MAPK cascade	Hs	biological process
metal ion binding	Hs	molecular function
positive regulation of apoptotic signaling pathway	Hs	biological process

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type	Score	E-value
ubiquitin ligase complex	Hs	cellular component	790	0.0
ubiquitin-protein transferase activity	Hs	molecular function	790	0.0
protein binding	Hs	molecular function	790	0.0
nucleus	Hs	cellular component	123	3.56e-29
nucleoplasm	Hs	cellular component	123	3.56e-29
nucleolus	Hs	cellular component	123	3.56e-29
cytoplasm	Hs	cellular component	123	3.56e-29
centrosome	Hs	cellular component	116	2.17e-27
cytosol	Hs	cellular component	123	3.56e-29
plasma membrane	Hs	cellular component	790	0.0
zinc ion binding	Hs	molecular function	790	0.0
transferase activity	Hs	molecular function	790	0.0
SCF ubiquitin ligase complex	Hs	cellular component	123	3.56e-29
cyclin binding	Hs	molecular function	123	3.56e-29
protein binding, bridging	Hs	molecular function	123	3.56e-29
cytoplasmic vesicle	Hs	cellular component	790	0.0
ubiquitin protein ligase binding	Hs	molecular function	123	3.56e-29
identical protein binding	Hs	molecular function	123	3.56e-29
intracellular membrane-bounded organelle	Hs	cellular component	790	0.0
metal ion binding	Hs	molecular function	790	0.0
protein dimerization activity	Hs	molecular function	116	2.17e-27
phosphothreonine residue binding	Hs	molecular function	123	3.56e-29
ubiquitin protein ligase activity	Hs	molecular function	116	2.17e-27
ubiquitin-protein transferase activator activity	Hs	molecular function	123	3.56e-29
Parkin-FBXW7-Cul1 ubiquitin ligase complex	Hs	cellular component	123	3.56e-29

GO Term	Analysis	Type	e-value
protein binding	SUPERFAMILY	molecular function	1.19E-65
zinc ion binding	ProSiteProfiles	molecular function	10.172