IPR Term	Analysis	Definition
HSP70_C_sf	Gene3D	Heat shock protein 70kD, C-terminal domain superfamily
HSP70_peptide-bd_sf	Gene3D	Heat shock protein 70kD, peptide-binding domain superfamily
Heat_shock_70_CS	ProSitePatterns	Heat shock protein 70, conserved site
HSP70_peptide-bd_sf	SUPERFAMILY	Heat shock protein 70kD, peptide-binding domain superfamily
Hsp_70_fam	PANTHER	Heat shock protein 70 family
Hsp_70_fam	PRINTS	Heat shock protein 70 family
Hsp_70_fam	Pfam	Heat shock protein 70 family
HSP70_C_sf	SUPERFAMILY	Heat shock protein 70kD, C-terminal domain superfamily

GO Term	Annotation Origin	Type
nucleotide binding	Orthology	molecular function
mRNA splicing, via spliceosome	Orthology	biological process
RNA binding	Orthology	molecular function
receptor binding	Orthology	molecular function
protein binding	Orthology	molecular function
ATP binding	Orthology	molecular function
extracellular region	Orthology	cellular component
extracellular space	Orthology	cellular component
intracellular	Orthology	cellular component
nucleus	Orthology	cellular component
nucleoplasm	Orthology	cellular component
nucleolus	Orthology	cellular component
cytoplasm	Orthology	cellular component
mitochondrion	Orthology	cellular component
lysosomal membrane	Orthology	cellular component
endoplasmic reticulum	Orthology	cellular component
centrosome	Orthology	cellular component
microtubule organizing center	Orthology	cellular component
cytosol	Orthology	cellular component
cytoskeleton	Orthology	cellular component
plasma membrane	Orthology	cellular component
focal adhesion	Orthology	cellular component
transcription, DNA-templated	Orthology	biological process
regulation of transcription, DNA-templated	Orthology	biological process
mRNA processing	Orthology	biological process
mRNA catabolic process	Orthology	biological process
protein folding	Orthology	biological process
negative regulation of cell proliferation	Orthology	biological process
RNA splicing	Orthology	biological process
positive regulation of gene expression	Orthology	biological process
membrane	Orthology	cellular component
nuclear speck	Orthology	cellular component
cytokine-mediated signaling pathway	Orthology	biological process
enzyme binding	Orthology	molecular function
ubiquitin protein ligase binding	Orthology	molecular function
vesicle	Orthology	cellular component
macromolecular complex	Orthology	cellular component
melanosome	Orthology	cellular component
negative regulation of apoptotic process	Orthology	biological process
myelin sheath	Orthology	cellular component
synapse	Orthology	cellular component
negative regulation of transcription, DNA-templated	Orthology	biological process
protein N-terminus binding	Orthology	molecular function
perinuclear region of cytoplasm	Orthology	cellular component
unfolded protein binding	Orthology	molecular function
negative regulation of cell death	Orthology	biological process
membrane organization	Orthology	biological process
extracellular exosome	Orthology	cellular component
spermatogenesis	Orthology	biological process
cell surface	Orthology	cellular component
cell differentiation	Orthology	biological process
cell body	Orthology	cellular component
intracellular part	Orthology	cellular component
binding	Orthology	molecular function
anion binding	Orthology	molecular function
nuclear part	Orthology	cellular component
endosome	Orthology	cellular component
cytoplasmic part	Orthology	cellular component
cellular protein modification process	Orthology	biological process
response to stress	Orthology	biological process
response to organic substance	Orthology	biological process
chemical synaptic transmission	Orthology	biological process
synapse part	Orthology	cellular component
neuron part	Orthology	cellular component
cell communication	Orthology	biological process
cellular response to stress	Orthology	biological process
nucleoside-triphosphatase activity	Orthology	molecular function
macromolecular complex binding	Orthology	molecular function
cellular component organization	Orthology	biological process
cell surface receptor signaling pathway	Orthology	biological process
negative regulation of signal transduction	Orthology	biological process
cellular response to organic substance	Orthology	biological process
protein ubiquitination	Orthology	biological process
regulation of cellular metabolic process	Orthology	biological process
proteolysis	Orthology	biological process
response to oxidative stress	Orthology	biological process
intracellular organelle part	Orthology	cellular component
cytoplasmic vesicle	Orthology	cellular component
endomembrane system	Orthology	cellular component
intracellular organelle lumen	Orthology	cellular component
lysosome	Orthology	cellular component
vacuolar part	Orthology	cellular component
cell adhesion molecule binding	Orthology	molecular function
immune system process	Orthology	biological process
animal organ development	Orthology	biological process
metabolic process	Orthology	biological process
transcription factor activity, sequence-specific DNA binding	Orthology	molecular function
cell cycle	Orthology	biological process
whole membrane	Orthology	cellular component
bounding membrane of organelle	Orthology	cellular component
organelle organization	Orthology	biological process
microtubule-based process	Orthology	biological process
negative regulation of transcription from RNA polymerase II promoter	Orthology	biological process
membrane part	Orthology	cellular component
intracellular signal transduction	Orthology	biological process
intracellular non-membrane-bounded organelle	Orthology	cellular component
nuclear lumen	Orthology	cellular component
protein phosphorylation	Orthology	biological process
cytoskeletal part	Orthology	cellular component
microtubule cytoskeleton	Orthology	cellular component
male gamete generation	Orthology	biological process
cell development	Orthology	biological process
sexual reproduction	Orthology	biological process
cellular process	Orthology	biological process
positive regulation of hydrolase activity	Orthology	biological process
plasma membrane part	Orthology	cellular component
integral component of membrane	Orthology	cellular component
carbohydrate derivative binding	Orthology	molecular function
transmembrane transport	Orthology	biological process
metal ion transport	Orthology	biological process

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type
ubiquitin ligase complex	Hs	cellular component
nucleotide binding	Hs	molecular function
mRNA splicing, via spliceosome	Hs	biological process
Prp19 complex	Hs	cellular component
RNA polymerase II transcription corepressor activity	Hs	molecular function
virus receptor activity	Hs	molecular function
G-protein coupled receptor binding	Hs	molecular function
phosphatidylserine binding	Hs	molecular function
RNA binding	Hs	molecular function
receptor binding	Hs	molecular function
protein binding	Hs	molecular function
ATP binding	Hs	molecular function
extracellular region	Hs	cellular component
extracellular space	Hs	cellular component
intracellular	Hs	cellular component
nucleus	Hs	cellular component
nucleoplasm	Hs	cellular component
spliceosomal complex	Hs	cellular component
nucleolus	Hs	cellular component
cytoplasm	Hs	cellular component
mitochondrion	Hs	cellular component
lysosomal membrane	Hs	cellular component
late endosome	Hs	cellular component
endoplasmic reticulum	Hs	cellular component
centrosome	Hs	cellular component
centriole	Hs	cellular component
microtubule organizing center	Hs	cellular component
cytosol	Hs	cellular component
cytoskeleton	Hs	cellular component
plasma membrane	Hs	cellular component
focal adhesion	Hs	cellular component
transcription, DNA-templated	Hs	biological process
regulation of transcription, DNA-templated	Hs	biological process
mRNA processing	Hs	biological process
mRNA catabolic process	Hs	biological process
protein folding	Hs	biological process
protein methylation	Hs	biological process
response to unfolded protein	Hs	biological process
neurotransmitter secretion	Hs	biological process
COP9 signalosome	Hs	cellular component
negative regulation of cell proliferation	Hs	biological process
RNA splicing	Hs	biological process
cellular response to starvation	Hs	biological process
positive regulation of gene expression	Hs	biological process
membrane	Hs	cellular component
viral process	Hs	biological process
inclusion body	Hs	cellular component
aggresome	Hs	cellular component
nuclear speck	Hs	cellular component
ATPase activity	Hs	molecular function
cytokine-mediated signaling pathway	Hs	biological process
enzyme binding	Hs	molecular function
MHC class II protein complex binding	Hs	molecular function
negative regulation of cell growth	Hs	biological process
negative regulation of transforming growth factor beta receptor signaling pathway	Hs	biological process
intracellular ribonucleoprotein complex	Hs	cellular component
heat shock protein binding	Hs	molecular function
denatured protein binding	Hs	molecular function
regulation of protein ubiquitination	Hs	biological process
negative regulation of protein ubiquitination	Hs	biological process
ubiquitin protein ligase binding	Hs	molecular function
regulation of protein stability	Hs	biological process
vesicle	Hs	cellular component
positive regulation of proteasomal ubiquitin-dependent protein catabolic process	Hs	biological process
macromolecular complex	Hs	cellular component
cellular response to oxidative stress	Hs	biological process
cellular response to heat	Hs	biological process
secretory granule lumen	Hs	cellular component
protein refolding	Hs	biological process
melanosome	Hs	cellular component
ATPase activity, coupled	Hs	molecular function
histone deacetylase binding	Hs	molecular function
negative regulation of apoptotic process	Hs	biological process
lysosomal lumen	Hs	cellular component
myelin sheath	Hs	cellular component
regulation of mRNA stability	Hs	biological process
protein binding involved in protein folding	Hs	molecular function
positive regulation by host of viral genome replication	Hs	biological process
synapse	Hs	cellular component
cadherin binding	Hs	molecular function
positive regulation of erythrocyte differentiation	Hs	biological process
negative regulation of transcription, DNA-templated	Hs	biological process
ATP metabolic process	Hs	biological process
viral entry into host cell	Hs	biological process
protein N-terminus binding	Hs	molecular function
positive regulation of mRNA splicing, via spliceosome	Hs	biological process
perinuclear region of cytoplasm	Hs	cellular component
protein stabilization	Hs	biological process
unfolded protein binding	Hs	molecular function
chaperone mediated protein folding requiring cofactor	Hs	biological process
positive regulation of NF-kappaB transcription factor activity	Hs	biological process
chaperone-mediated protein complex assembly	Hs	biological process
regulation of cell cycle	Hs	biological process
C3HC4-type RING finger domain binding	Hs	molecular function
negative regulation of cell death	Hs	biological process
membrane organization	Hs	biological process
clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane	Hs	cellular component
regulation of protein complex stability	Hs	biological process
late endosomal microautophagy	Hs	biological process
extracellular exosome	Hs	cellular component
blood microparticle	Hs	cellular component
positive regulation of microtubule nucleation	Hs	biological process
negative regulation of transcription from RNA polymerase II promoter in response to stress	Hs	biological process
disordered domain specific binding	Hs	molecular function
lumenal side of lysosomal membrane	Hs	cellular component
presynapse	Hs	cellular component
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	Hs	biological process
regulation of mitotic spindle assembly	Hs	biological process
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	Hs	biological process
ficolin-1-rich granule lumen	Hs	cellular component
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	Hs	biological process
synaptonemal complex	Hs	cellular component
male germ cell nucleus	Hs	cellular component
positive regulation of protein phosphorylation	Hs	biological process
zona pellucida receptor complex	Hs	cellular component
spindle	Hs	cellular component
male meiotic nuclear division	Hs	biological process
male meiosis I	Hs	biological process
spermatogenesis	Hs	biological process
spermatid development	Hs	biological process
binding of sperm to zona pellucida	Hs	biological process
response to heat	Hs	biological process
response to cold	Hs	biological process
cell surface	Hs	cellular component
cell differentiation	Hs	biological process
positive regulation of ATPase activity	Hs	biological process
CatSper complex	Hs	cellular component
cell body	Hs	cellular component
glycolipid binding	Hs	molecular function
synaptonemal complex disassembly	Hs	biological process
meiotic spindle	Hs	cellular component
positive regulation of calcium-transporting ATPase activity	Hs	biological process

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type	Score	E-value
ubiquitin ligase complex	Hs	cellular component	1091	0.0
nucleotide binding	Hs	molecular function	1091	0.0
Prp19 complex	Hs	cellular component	1091	0.0
RNA polymerase II transcription corepressor activity	Hs	molecular function	1033	0.0
virus receptor activity	Hs	molecular function	1033	0.0
G-protein coupled receptor binding	Hs	molecular function	1091	0.0
phosphatidylserine binding	Hs	molecular function	1091	0.0
RNA binding	Hs	molecular function	1091	0.0
receptor binding	Hs	molecular function	1033	0.0
protein binding	Hs	molecular function	1091	0.0
ATP binding	Hs	molecular function	1091	0.0
extracellular region	Hs	cellular component	1091	0.0
extracellular space	Hs	cellular component	1091	0.0
intracellular	Hs	cellular component	1091	0.0
nucleus	Hs	cellular component	1091	0.0
nucleoplasm	Hs	cellular component	1091	0.0
spliceosomal complex	Hs	cellular component	1091	0.0
nucleolus	Hs	cellular component	1091	0.0
cytoplasm	Hs	cellular component	1091	0.0
mitochondrion	Hs	cellular component	1033	0.0
lysosomal membrane	Hs	cellular component	1091	0.0
late endosome	Hs	cellular component	1091	0.0
endoplasmic reticulum	Hs	cellular component	1033	0.0
centrosome	Hs	cellular component	1033	0.0
centriole	Hs	cellular component	1033	0.0
microtubule organizing center	Hs	cellular component	1033	0.0
cytosol	Hs	cellular component	1091	0.0
cytoskeleton	Hs	cellular component	1033	0.0
plasma membrane	Hs	cellular component	1091	0.0
focal adhesion	Hs	cellular component	1091	0.0
COP9 signalosome	Hs	cellular component	1033	0.0
membrane	Hs	cellular component	1091	0.0
inclusion body	Hs	cellular component	1033	0.0
aggresome	Hs	cellular component	1033	0.0
nuclear speck	Hs	cellular component	1033	0.0
ATPase activity	Hs	molecular function	1091	0.0
enzyme binding	Hs	molecular function	1091	0.0
MHC class II protein complex binding	Hs	molecular function	1091	0.0
intracellular ribonucleoprotein complex	Hs	cellular component	1091	0.0
heat shock protein binding	Hs	molecular function	1091	0.0
denatured protein binding	Hs	molecular function	1033	0.0
ubiquitin protein ligase binding	Hs	molecular function	1091	0.0
vesicle	Hs	cellular component	1033	0.0
macromolecular complex	Hs	cellular component	1033	0.0
secretory granule lumen	Hs	cellular component	1091	0.0
melanosome	Hs	cellular component	1091	0.0
ATPase activity, coupled	Hs	molecular function	1091	0.0
histone deacetylase binding	Hs	molecular function	1033	0.0
lysosomal lumen	Hs	cellular component	1091	0.0
myelin sheath	Hs	cellular component	1091	0.0
protein binding involved in protein folding	Hs	molecular function	1033	0.0
synapse	Hs	cellular component	1091	0.0
cadherin binding	Hs	molecular function	1091	0.0
protein N-terminus binding	Hs	molecular function	1033	0.0
perinuclear region of cytoplasm	Hs	cellular component	1033	0.0
unfolded protein binding	Hs	molecular function	1091	0.0
C3HC4-type RING finger domain binding	Hs	molecular function	1091	0.0
clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane	Hs	cellular component	1091	0.0
extracellular exosome	Hs	cellular component	1091	0.0
blood microparticle	Hs	cellular component	1091	0.0
disordered domain specific binding	Hs	molecular function	1033	0.0
lumenal side of lysosomal membrane	Hs	cellular component	1091	0.0
presynapse	Hs	cellular component	1091	0.0
ficolin-1-rich granule lumen	Hs	cellular component	1091	0.0