Gene Card
Best human hits
USP15; USP2; USP8
Species
Unique Gene ID
Phmamm.g00005595
Gene Model ID
Phmamm.CG.MTP2014.S220.g05595
Location
S220:28610..32009
Transcript Models and Sequences
AHC0AAA66YA17
Plate: Plate_66_A17
AHC0AAA116YI10
Plate: Plate_116_I10
AHC0AAA211YD20
Plate: Plate_211_D20
AHC0AAA239YO09
Plate: Plate_239_O09
AHC0AAA244YH10
Plate: Plate_244_H10
n/a
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You can Press 'Ctrl' Key + Left Mouse Click on nodes to do a multiple selection.

IPR Term | Analysis | Definition |
---|---|---|
Rhodanese-like_dom_sf | Gene3D | Rhodanese-like domain superfamily |
USP_CS | ProSitePatterns | Ubiquitin specific protease, conserved site |
Rhodanese-like_dom | ProSiteProfiles | Rhodanese-like domain |
USP8_dimer | Pfam | USP8 dimerisation domain |
Peptidase_C19_UCH | Pfam | Peptidase C19, ubiquitin carboxyl-terminal hydrolase |
Rhodanese-like_dom_sf | SUPERFAMILY | Rhodanese-like domain superfamily |
USP_dom | ProSiteProfiles | Ubiquitin specific protease domain |
GO Term | Annotation Origin | Type |
---|---|---|
catalytic activity | Blast | molecular function |
protein binding | Orthology | molecular function |
nucleus | Orthology | cellular component |
nucleoplasm | Blast | cellular component |
cytoplasm | Orthology | cellular component |
mitochondrion | Blast | cellular component |
endosome | Orthology | cellular component |
early endosome | Orthology | cellular component |
centrosome | Blast | cellular component |
cytosol | Orthology | cellular component |
plasma membrane | Orthology | cellular component |
proteolysis | Orthology | biological process |
cell cycle | Orthology | biological process |
peptidase activity | Orthology | molecular function |
cell proliferation | Orthology | biological process |
membrane | Orthology | cellular component |
hydrolase activity | Orthology | molecular function |
midbody | Orthology | cellular component |
ubiquitin protein ligase binding | Blast | molecular function |
identical protein binding | Blast | molecular function |
metal ion binding | Blast | molecular function |
perinuclear region of cytoplasm | Blast | cellular component |
positive regulation of canonical Wnt signaling pathway | Orthology | biological process |
membrane organization | Orthology | biological process |
cell division | Orthology | biological process |
endopeptidase activity | Orthology | molecular function |
peptidase activity, acting on L-amino acid peptides | Orthology | molecular function |
organelle organization | Orthology | biological process |
intracellular organelle part | Orthology | cellular component |
whole membrane | Orthology | cellular component |
bounding membrane of organelle | Orthology | cellular component |
organelle | Orthology | cellular component |
postsynapse | Orthology | cellular component |
neuron part | Orthology | cellular component |
plasma membrane part | Orthology | cellular component |
membrane part | Orthology | cellular component |
cell adhesion molecule binding | Orthology | molecular function |
receptor binding | Blast | molecular function |
cell periphery | Blast | cellular component |
cytoplasmic part | Blast | cellular component |
GO Term | SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae |
Type |
---|---|---|
mitotic cytokinesis | Hs | biological process |
cysteine-type endopeptidase activity | Hs | molecular function |
thiol-dependent ubiquitin-specific protease activity | Hs | molecular function |
protein binding | Hs | molecular function |
nucleus | Hs | cellular component |
cytoplasm | Hs | cellular component |
endosome | Hs | cellular component |
early endosome | Hs | cellular component |
cytosol | Hs | cellular component |
plasma membrane | Hs | cellular component |
proteolysis | Hs | biological process |
ubiquitin-dependent protein catabolic process | Hs | biological process |
endosome organization | Hs | biological process |
cell cycle | Hs | biological process |
peptidase activity | Hs | molecular function |
cysteine-type peptidase activity | Hs | molecular function |
cell proliferation | Hs | biological process |
endosome membrane | Hs | cellular component |
postsynaptic density | Hs | cellular component |
membrane | Hs | cellular component |
protein deubiquitination | Hs | biological process |
hydrolase activity | Hs | molecular function |
SH3 domain binding | Hs | molecular function |
extrinsic component of plasma membrane | Hs | cellular component |
midbody | Hs | cellular component |
extrinsic component of endosome membrane | Hs | cellular component |
thiol-dependent ubiquitinyl hydrolase activity | Hs | molecular function |
dendritic spine | Hs | cellular component |
cadherin binding | Hs | molecular function |
protein K63-linked deubiquitination | Hs | biological process |
protein K48-linked deubiquitination | Hs | biological process |
positive regulation of canonical Wnt signaling pathway | Hs | biological process |
GO Term | SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae |
Type | Score | E-value |
---|---|---|---|---|
catalytic activity | Hs | molecular function | 193 | 2.15e-50 |
cysteine-type endopeptidase activity | Hs | molecular function | 383 | 9.46e-115 |
thiol-dependent ubiquitin-specific protease activity | Hs | molecular function | 383 | 9.46e-115 |
transforming growth factor beta receptor binding | Hs | molecular function | 193 | 2.15e-50 |
protein binding | Hs | molecular function | 383 | 9.46e-115 |
nucleus | Hs | cellular component | 383 | 9.46e-115 |
nucleoplasm | Hs | cellular component | 207 | 7.61e-57 |
cytoplasm | Hs | cellular component | 383 | 9.46e-115 |
mitochondrion | Hs | cellular component | 193 | 2.15e-50 |
endosome | Hs | cellular component | 383 | 9.46e-115 |
early endosome | Hs | cellular component | 383 | 9.46e-115 |
centrosome | Hs | cellular component | 207 | 7.61e-57 |
cytosol | Hs | cellular component | 383 | 9.46e-115 |
plasma membrane | Hs | cellular component | 383 | 9.46e-115 |
cell cortex | Hs | cellular component | 207 | 7.61e-57 |
peptidase activity | Hs | molecular function | 383 | 9.46e-115 |
cysteine-type peptidase activity | Hs | molecular function | 383 | 9.46e-115 |
endosome membrane | Hs | cellular component | 383 | 9.46e-115 |
postsynaptic density | Hs | cellular component | 383 | 9.46e-115 |
membrane | Hs | cellular component | 383 | 9.46e-115 |
hydrolase activity | Hs | molecular function | 383 | 9.46e-115 |
SH3 domain binding | Hs | molecular function | 383 | 9.46e-115 |
extrinsic component of plasma membrane | Hs | cellular component | 383 | 9.46e-115 |
cyclin binding | Hs | molecular function | 207 | 7.61e-57 |
midbody | Hs | cellular component | 383 | 9.46e-115 |
extrinsic component of endosome membrane | Hs | cellular component | 383 | 9.46e-115 |
ubiquitin protein ligase binding | Hs | molecular function | 207 | 7.61e-57 |
thiol-dependent ubiquitinyl hydrolase activity | Hs | molecular function | 383 | 9.46e-115 |
identical protein binding | Hs | molecular function | 207 | 7.61e-57 |
dendritic spine | Hs | cellular component | 383 | 9.46e-115 |
cadherin binding | Hs | molecular function | 383 | 9.46e-115 |
SMAD binding | Hs | molecular function | 193 | 2.15e-50 |
metal ion binding | Hs | molecular function | 207 | 7.61e-57 |
perinuclear region of cytoplasm | Hs | cellular component | 207 | 7.61e-57 |
ubiquitin modification-dependent histone binding | Hs | molecular function | 193 | 2.15e-50 |
GO Term | Analysis | Type | e-value |
---|---|---|---|
ubiquitin-dependent protein catabolic process | ProSitePatterns | biological process | |
protein deubiquitination | Pfam | biological process | 4.1E-67 |
thiol-dependent ubiquitinyl hydrolase activity | Pfam | molecular function | 4.1E-67 |