IPR Term	Analysis	Definition
Prot_kinase_dom	ProSiteProfiles	Protein kinase domain
Prot_kinase_dom	Pfam	Protein kinase domain
Ser/Thr_kinase_AS	ProSitePatterns	Serine/threonine-protein kinase, active site
Kinase-like_dom_sf	SUPERFAMILY	Protein kinase-like domain superfamily
Prot_kinase_dom	SMART	Protein kinase domain
Protein_kinase_ATP_BS	ProSitePatterns	Protein kinase, ATP binding site
MAP_kinase_CS	ProSitePatterns	Mitogen-activated protein (MAP) kinase, conserved site
MAPK_ERK1/2	PRINTS	Mitogen-activated protein (MAP) kinase, ERK1/2

GO Term	Annotation Origin	Type
nucleotide binding	Orthology	molecular function
DNA binding	Orthology	molecular function
protein kinase activity	Orthology	molecular function
protein serine/threonine kinase activity	Orthology	molecular function
protein binding	Orthology	molecular function
ATP binding	Orthology	molecular function
extracellular region	Orthology	cellular component
intracellular	Orthology	cellular component
nucleus	Orthology	cellular component
nuclear envelope	Orthology	cellular component
nucleoplasm	Orthology	cellular component
cytoplasm	Orthology	cellular component
mitochondrion	Orthology	cellular component
early endosome	Orthology	cellular component
Golgi apparatus	Orthology	cellular component
microtubule organizing center	Orthology	cellular component
cytosol	Orthology	cellular component
cytoskeleton	Orthology	cellular component
plasma membrane	Orthology	cellular component
focal adhesion	Orthology	cellular component
transcription, DNA-templated	Orthology	biological process
regulation of transcription, DNA-templated	Orthology	biological process
protein phosphorylation	Orthology	biological process
apoptotic process	Orthology	biological process
chemotaxis	Orthology	biological process
cellular response to DNA damage stimulus	Orthology	biological process
cell cycle	Orthology	biological process
signal transduction	Orthology	biological process
chemical synaptic transmission	Orthology	biological process
axon guidance	Orthology	biological process
heart development	Orthology	biological process
transcription factor binding	Orthology	molecular function
positive regulation of cell proliferation	Orthology	biological process
positive regulation of gene expression	Orthology	biological process
membrane	Orthology	cellular component
kinase activity	Orthology	molecular function
phosphorylation	Orthology	biological process
transferase activity	Orthology	molecular function
protein kinase binding	Orthology	molecular function
cell differentiation	Orthology	biological process
axon	Orthology	cellular component
response to lipopolysaccharide	Orthology	biological process
intracellular signal transduction	Orthology	biological process
identical protein binding	Orthology	molecular function
positive regulation of transcription, DNA-templated	Orthology	biological process
positive regulation of transcription from RNA polymerase II promoter	Orthology	biological process
extracellular exosome	Orthology	cellular component
cellular response to organic substance	Orthology	biological process
positive regulation of catalytic activity	Orthology	biological process
positive regulation of signal transduction	Orthology	biological process
endosome	Orthology	cellular component
cytoskeletal part	Orthology	cellular component
microtubule cytoskeleton	Orthology	cellular component
membrane raft	Orthology	cellular component
plasma membrane region	Orthology	cellular component
nervous system process	Orthology	biological process
cell surface receptor signaling pathway	Orthology	biological process
animal organ development	Orthology	biological process
anatomical structure morphogenesis	Orthology	biological process
cell development	Orthology	biological process
regulation of signal transduction	Orthology	biological process
phosphate-containing compound metabolic process	Orthology	biological process
sensory perception	Orthology	biological process
cellular metabolic process	Orthology	biological process
organic substance metabolic process	Orthology	biological process
enzyme binding	Orthology	molecular function
blood coagulation	Orthology	biological process
cellular process	Orthology	biological process
cell migration	Orthology	biological process
regulation of transcription from RNA polymerase II promoter	Orthology	biological process
cell	Orthology	cellular component
cell projection	Orthology	cellular component
organelle organization	Orthology	biological process
DNA metabolic process	Orthology	biological process
transferase activity, transferring phosphorus-containing groups	Orthology	molecular function
cytoplasmic part	Orthology	cellular component
cell communication	Orthology	biological process
cellular response to stress	Orthology	biological process
response to oxidative stress	Orthology	biological process
cellular protein modification process	Orthology	biological process
cytoplasmic vesicle	Orthology	cellular component
lysosome	Orthology	cellular component
vacuolar part	Orthology	cellular component
endomembrane system	Orthology	cellular component
intracellular organelle lumen	Orthology	cellular component
protein autophosphorylation	Orthology	biological process
immune response	Orthology	biological process
neuronal cell body	Orthology	cellular component
response to organic substance	Orthology	biological process
response to stimulus	Orthology	biological process
immune system process	Orthology	biological process
regulation of molecular function	Orthology	biological process
transcription factor activity, sequence-specific DNA binding	Orthology	molecular function
head development	Orthology	biological process
cytokine-mediated signaling pathway	Orthology	biological process
defense response	Orthology	biological process
intracellular organelle part	Orthology	cellular component
metallopeptidase activity	Orthology	molecular function
positive regulation of hydrolase activity	Orthology	biological process
nuclear body	Blast	cellular component

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type
MAPK cascade	Hs	biological process
nucleotide binding	Hs	molecular function
activation of MAPK activity	Hs	biological process
phosphotyrosine residue binding	Hs	molecular function
positive regulation of protein phosphorylation	Hs	biological process
DNA binding	Hs	molecular function
protein kinase activity	Hs	molecular function
protein serine/threonine kinase activity	Hs	molecular function
MAP kinase activity	Hs	molecular function
MAP kinase kinase activity	Hs	molecular function
protein binding	Hs	molecular function
ATP binding	Hs	molecular function
extracellular region	Hs	cellular component
intracellular	Hs	cellular component
nucleus	Hs	cellular component
nuclear envelope	Hs	cellular component
nucleoplasm	Hs	cellular component
cytoplasm	Hs	cellular component
mitochondrion	Hs	cellular component
early endosome	Hs	cellular component
late endosome	Hs	cellular component
Golgi apparatus	Hs	cellular component
microtubule organizing center	Hs	cellular component
spindle	Hs	cellular component
cytosol	Hs	cellular component
cytoskeleton	Hs	cellular component
plasma membrane	Hs	cellular component
caveola	Hs	cellular component
focal adhesion	Hs	cellular component
transcription, DNA-templated	Hs	biological process
regulation of transcription, DNA-templated	Hs	biological process
protein phosphorylation	Hs	biological process
apoptotic process	Hs	biological process
chemotaxis	Hs	biological process
cellular response to DNA damage stimulus	Hs	biological process
cell cycle	Hs	biological process
signal transduction	Hs	biological process
chemical synaptic transmission	Hs	biological process
axon guidance	Hs	biological process
heart development	Hs	biological process
learning or memory	Hs	biological process
transcription factor binding	Hs	molecular function
positive regulation of cell proliferation	Hs	biological process
RNA polymerase II carboxy-terminal domain kinase activity	Hs	molecular function
fibroblast growth factor receptor signaling pathway	Hs	biological process
response to toxic substance	Hs	biological process
animal organ morphogenesis	Hs	biological process
positive regulation of gene expression	Hs	biological process
positive regulation of peptidyl-threonine phosphorylation	Hs	biological process
neural crest cell development	Hs	biological process
regulation of phosphatidylinositol 3-kinase signaling	Hs	biological process
diadenosine tetraphosphate biosynthetic process	Hs	biological process
membrane	Hs	cellular component
viral process	Hs	biological process
kinase activity	Hs	molecular function
phosphorylation	Hs	biological process
transferase activity	Hs	molecular function
peptidyl-serine phosphorylation	Hs	biological process
peptidyl-threonine phosphorylation	Hs	biological process
sensory perception of pain	Hs	biological process
arachidonic acid metabolic process	Hs	biological process
protein kinase binding	Hs	molecular function
phosphatase binding	Hs	molecular function
platelet activation	Hs	biological process
regulation of ossification	Hs	biological process
positive regulation of cell migration	Hs	biological process
axon	Hs	cellular component
BMP signaling pathway	Hs	biological process
regulation of cellular pH	Hs	biological process
thyroid gland development	Hs	biological process
pseudopodium	Hs	cellular component
mitogen-activated protein kinase kinase kinase binding	Hs	molecular function
regulation of protein stability	Hs	biological process
lipopolysaccharide-mediated signaling pathway	Hs	biological process
positive regulation of telomere maintenance via telomerase	Hs	biological process
response to lipopolysaccharide	Hs	biological process
dendrite cytoplasm	Hs	cellular component
positive regulation of histone phosphorylation	Hs	biological process
positive regulation of protein import into nucleus, translocation	Hs	biological process
cellular response to amino acid starvation	Hs	biological process
cellular response to reactive oxygen species	Hs	biological process
positive regulation of histone acetylation	Hs	biological process
response to nicotine	Hs	biological process
intracellular signal transduction	Hs	biological process
azurophil granule lumen	Hs	cellular component
peptidyl-tyrosine autophosphorylation	Hs	biological process
Fc-epsilon receptor signaling pathway	Hs	biological process
identical protein binding	Hs	molecular function
perikaryon	Hs	cellular component
response to exogenous dsRNA	Hs	biological process
response to estrogen	Hs	biological process
negative regulation of cell differentiation	Hs	biological process
positive regulation of translation	Hs	biological process
positive regulation of transcription, DNA-templated	Hs	biological process
positive regulation of transcription from RNA polymerase II promoter	Hs	biological process
thymus development	Hs	biological process
T cell receptor signaling pathway	Hs	biological process
B cell receptor signaling pathway	Hs	biological process
regulation of sequence-specific DNA binding transcription factor activity	Hs	biological process
cartilage development	Hs	biological process
stress-activated MAPK cascade	Hs	biological process
regulation of cytoskeleton organization	Hs	biological process
long-term synaptic potentiation	Hs	biological process
face development	Hs	biological process
JAK-STAT cascade involved in growth hormone signaling pathway	Hs	biological process
extracellular exosome	Hs	cellular component
positive regulation of ERK1 and ERK2 cascade	Hs	biological process
interleukin-1-mediated signaling pathway	Hs	biological process
cellular response to mechanical stimulus	Hs	biological process
cellular response to cadmium ion	Hs	biological process
cellular response to organic substance	Hs	biological process
cellular response to tumor necrosis factor	Hs	biological process
mitotic spindle	Hs	cellular component
scaffold protein binding	Hs	molecular function
cellular response to dopamine	Hs	biological process
positive regulation of xenophagy	Hs	biological process
ficolin-1-rich granule lumen	Hs	cellular component
positive regulation of metallopeptidase activity	Hs	biological process

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type	Score	E-value
nucleotide binding	Hs	molecular function	598	0.0
phosphotyrosine residue binding	Hs	molecular function	598	0.0
DNA binding	Hs	molecular function	598	0.0
protein kinase activity	Hs	molecular function	598	0.0
protein serine/threonine kinase activity	Hs	molecular function	598	0.0
MAP kinase activity	Hs	molecular function	598	0.0
MAP kinase kinase activity	Hs	molecular function	598	0.0
protein binding	Hs	molecular function	598	0.0
ATP binding	Hs	molecular function	598	0.0
extracellular region	Hs	cellular component	598	0.0
intracellular	Hs	cellular component	580	0.0
nucleus	Hs	cellular component	598	0.0
nuclear envelope	Hs	cellular component	580	0.0
nucleoplasm	Hs	cellular component	598	0.0
cytoplasm	Hs	cellular component	598	0.0
mitochondrion	Hs	cellular component	598	0.0
early endosome	Hs	cellular component	598	0.0
late endosome	Hs	cellular component	598	0.0
Golgi apparatus	Hs	cellular component	598	0.0
microtubule organizing center	Hs	cellular component	598	0.0
spindle	Hs	cellular component	598	0.0
cytosol	Hs	cellular component	598	0.0
cytoskeleton	Hs	cellular component	598	0.0
plasma membrane	Hs	cellular component	598	0.0
caveola	Hs	cellular component	598	0.0
focal adhesion	Hs	cellular component	598	0.0
transcription factor binding	Hs	molecular function	598	0.0
RNA polymerase II carboxy-terminal domain kinase activity	Hs	molecular function	598	0.0
membrane	Hs	cellular component	598	0.0
kinase activity	Hs	molecular function	598	0.0
PML body	Hs	cellular component	344	6.45e-112
transferase activity	Hs	molecular function	598	0.0
protein kinase binding	Hs	molecular function	598	0.0
phosphatase binding	Hs	molecular function	598	0.0
axon	Hs	cellular component	598	0.0
pseudopodium	Hs	cellular component	598	0.0
mitogen-activated protein kinase kinase kinase binding	Hs	molecular function	598	0.0
dendrite cytoplasm	Hs	cellular component	598	0.0
azurophil granule lumen	Hs	cellular component	598	0.0
identical protein binding	Hs	molecular function	598	0.0
perikaryon	Hs	cellular component	598	0.0
mitogen-activated protein kinase binding	Hs	molecular function	344	6.45e-112
extracellular exosome	Hs	cellular component	598	0.0
mitotic spindle	Hs	cellular component	598	0.0
scaffold protein binding	Hs	molecular function	580	0.0
ficolin-1-rich granule lumen	Hs	cellular component	598	0.0

GO Term	Analysis	Type	e-value
protein kinase activity	SMART	molecular function	4.8E-91
MAP kinase activity	PRINTS	molecular function	2.8E-34
ATP binding	SMART	molecular function	4.8E-91
protein phosphorylation	SMART	biological process	4.8E-91