IPR Term	Analysis	Definition
PE/DAG-bd	ProSiteProfiles	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
PE/DAG-bd	CDD	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
PE/DAG-bd	ProSitePatterns	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
Protein_kinase_ATP_BS	ProSitePatterns	Protein kinase, ATP binding site
PE/DAG-bd	Pfam	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
RBD_dom	Pfam	Raf-like Ras-binding
PE/DAG-bd	SMART	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
Prot_kinase_dom	ProSiteProfiles	Protein kinase domain
Ser-Thr/Tyr_kinase_cat_dom	Pfam	Serine-threonine/tyrosine-protein kinase, catalytic domain
Kinase-like_dom_sf	SUPERFAMILY	Protein kinase-like domain superfamily
Ubiquitin-like_domsf	SUPERFAMILY	Ubiquitin-like domain superfamily

GO Term	Annotation Origin	Type
nucleotide binding	Orthology	molecular function
protein kinase activity	Orthology	molecular function
protein serine/threonine kinase activity	Orthology	molecular function
signal transducer activity	Blast	molecular function
calcium ion binding	Orthology	molecular function
protein binding	Orthology	molecular function
ATP binding	Orthology	molecular function
intracellular	Orthology	cellular component
nucleus	Orthology	cellular component
cytoplasm	Orthology	cellular component
mitochondrion	Orthology	cellular component
cytosol	Orthology	cellular component
plasma membrane	Orthology	cellular component
cellular protein modification process	Orthology	biological process
protein phosphorylation	Orthology	biological process
signal transduction	Orthology	biological process
multicellular organism development	Orthology	biological process
negative regulation of signal transduction	Orthology	biological process
positive regulation of gene expression	Orthology	biological process
membrane	Orthology	cellular component
kinase activity	Orthology	molecular function
phosphorylation	Orthology	biological process
transferase activity	Orthology	molecular function
cell differentiation	Orthology	biological process
intracellular signal transduction	Orthology	biological process
regulation of cell proliferation	Orthology	biological process
identical protein binding	Orthology	molecular function
neuron projection	Orthology	cellular component
negative regulation of apoptotic process	Orthology	biological process
intracellular membrane-bounded organelle	Orthology	cellular component
cell body	Orthology	cellular component
metal ion binding	Orthology	molecular function
protein heterodimerization activity	Orthology	molecular function
establishment of protein localization to membrane	Orthology	biological process
response to hypoxia	Orthology	biological process
Golgi apparatus	Orthology	cellular component
apoptotic process	Orthology	biological process
heart development	Orthology	biological process
cell proliferation	Orthology	biological process
negative regulation of cell proliferation	Orthology	biological process
nuclear speck	Orthology	cellular component
enzyme binding	Orthology	molecular function
wound healing	Orthology	biological process
regulation of apoptotic process	Orthology	biological process
positive regulation of catalytic activity	Orthology	biological process
positive regulation of transcription from RNA polymerase II promoter	Orthology	biological process
positive regulation of signal transduction	Orthology	biological process
nervous system process	Orthology	biological process
animal organ development	Orthology	biological process
anatomical structure morphogenesis	Orthology	biological process
protein kinase binding	Orthology	molecular function
regulation of signal transduction	Orthology	biological process
regulation of cellular metabolic process	Orthology	biological process
proteolysis	Orthology	biological process
developmental process	Orthology	biological process
immune system process	Orthology	biological process
response to organic substance	Orthology	biological process
axon development	Orthology	biological process
cellular response to stress	Orthology	biological process
response to wounding	Orthology	biological process
axonogenesis	Orthology	biological process
cell surface receptor signaling pathway	Orthology	biological process
immune response	Orthology	biological process
protein oligomerization	Orthology	biological process
organelle organization	Orthology	biological process
chemical synaptic transmission	Orthology	biological process
head development	Orthology	biological process
cell morphogenesis involved in differentiation	Orthology	biological process
cell adhesion	Orthology	biological process
synapse part	Orthology	cellular component
intracellular transport	Orthology	biological process
neuron part	Orthology	cellular component
membrane organization	Orthology	biological process
cellular process	Orthology	biological process
cell	Orthology	cellular component
whole membrane	Orthology	cellular component
mitochondrial membrane	Orthology	cellular component
bounding membrane of organelle	Orthology	cellular component
regulation of catalytic activity	Orthology	biological process
enzyme activator activity	Orthology	molecular function
blood coagulation	Orthology	biological process
cell projection	Orthology	cellular component
plasma membrane region	Orthology	cellular component
ion transport	Orthology	biological process
transmembrane transport	Orthology	biological process
small GTPase mediated signal transduction	Orthology	biological process
endopeptidase activity	Orthology	molecular function
cellular response to organic substance	Orthology	biological process
cell motility	Orthology	biological process

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type
MAPK cascade	Hs	biological process
nucleotide binding	Hs	molecular function
activation of MAPKK activity	Hs	biological process
protein kinase activity	Hs	molecular function
protein serine/threonine kinase activity	Hs	molecular function
MAP kinase kinase kinase activity	Hs	molecular function
signal transducer activity, downstream of receptor	Hs	molecular function
calcium ion binding	Hs	molecular function
protein binding	Hs	molecular function
ATP binding	Hs	molecular function
intracellular	Hs	cellular component
nucleus	Hs	cellular component
cytoplasm	Hs	cellular component
mitochondrion	Hs	cellular component
cytosol	Hs	cellular component
plasma membrane	Hs	cellular component
cellular protein modification process	Hs	biological process
protein phosphorylation	Hs	biological process
signal transduction	Hs	biological process
multicellular organism development	Hs	biological process
visual learning	Hs	biological process
animal organ morphogenesis	Hs	biological process
negative regulation of signal transduction	Hs	biological process
positive regulation of gene expression	Hs	biological process
membrane	Hs	cellular component
kinase activity	Hs	molecular function
phosphorylation	Hs	biological process
transferase activity	Hs	molecular function
Ras GTPase binding	Hs	molecular function
cell differentiation	Hs	biological process
thyroid gland development	Hs	biological process
mitogen-activated protein kinase kinase binding	Hs	molecular function
regulation of TOR signaling	Hs	biological process
regulation of proteasomal ubiquitin-dependent protein catabolic process	Hs	biological process
positive regulation of peptidyl-serine phosphorylation	Hs	biological process
somatic stem cell population maintenance	Hs	biological process
intracellular signal transduction	Hs	biological process
regulation of cell proliferation	Hs	biological process
identical protein binding	Hs	molecular function
neuron projection	Hs	cellular component
negative regulation of apoptotic process	Hs	biological process
intracellular membrane-bounded organelle	Hs	cellular component
positive T cell selection	Hs	biological process
response to peptide hormone	Hs	biological process
negative regulation of neuron apoptotic process	Hs	biological process
cell body	Hs	cellular component
regulation of T cell differentiation	Hs	biological process
alpha-beta T cell differentiation	Hs	biological process
metal ion binding	Hs	molecular function
protein heterodimerization activity	Hs	molecular function
thymus development	Hs	biological process
regulation of axon regeneration	Hs	biological process
positive regulation of axon regeneration	Hs	biological process
positive regulation of axonogenesis	Hs	biological process
T cell receptor signaling pathway	Hs	biological process
protein heterooligomerization	Hs	biological process
positive regulation of stress fiber assembly	Hs	biological process
response to cAMP	Hs	biological process
long-term synaptic potentiation	Hs	biological process
head morphogenesis	Hs	biological process
face development	Hs	biological process
positive regulation of ERK1 and ERK2 cascade	Hs	biological process
cellular response to calcium ion	Hs	biological process
establishment of protein localization to membrane	Hs	biological process
positive regulation of substrate adhesion-dependent cell spreading	Hs	biological process
negative regulation of synaptic vesicle exocytosis	Hs	biological process
response to hypoxia	Hs	biological process
cellular glucose homeostasis	Hs	biological process
positive regulation of protein phosphorylation	Hs	biological process
mitochondrial outer membrane	Hs	cellular component
Golgi apparatus	Hs	cellular component
apoptotic process	Hs	biological process
activation of adenylate cyclase activity	Hs	biological process
heart development	Hs	biological process
adenylate cyclase binding	Hs	molecular function
cell proliferation	Hs	biological process
negative regulation of cell proliferation	Hs	biological process
adenylate cyclase activator activity	Hs	molecular function
nuclear speck	Hs	cellular component
enzyme binding	Hs	molecular function
platelet activation	Hs	biological process
pseudopodium	Hs	cellular component
negative regulation of protein complex assembly	Hs	biological process
ion transmembrane transport	Hs	biological process
regulation of Rho protein signal transduction	Hs	biological process
wound healing	Hs	biological process
regulation of apoptotic process	Hs	biological process
positive regulation of catalytic activity	Hs	biological process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	Hs	biological process
intermediate filament cytoskeleton organization	Hs	biological process
regulation of cell differentiation	Hs	biological process
positive regulation of transcription from RNA polymerase II promoter	Hs	biological process
neurotrophin TRK receptor signaling pathway	Hs	biological process
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	Hs	biological process
regulation of cell motility	Hs	biological process

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type	Score	E-value
nucleotide binding	Hs	molecular function	271	3.30e-81
protein kinase activity	Hs	molecular function	271	3.30e-81
protein serine/threonine kinase activity	Hs	molecular function	271	3.30e-81
MAP kinase kinase kinase activity	Hs	molecular function	271	3.30e-81
signal transducer activity	Hs	molecular function	122	4.58e-29
signal transducer activity, downstream of receptor	Hs	molecular function	271	3.30e-81
calcium ion binding	Hs	molecular function	271	3.30e-81
protein binding	Hs	molecular function	271	3.30e-81
ATP binding	Hs	molecular function	271	3.30e-81
intracellular	Hs	cellular component	271	3.30e-81
nucleus	Hs	cellular component	271	3.30e-81
cytoplasm	Hs	cellular component	271	3.30e-81
mitochondrion	Hs	cellular component	271	3.30e-81
cytosol	Hs	cellular component	271	3.30e-81
plasma membrane	Hs	cellular component	271	3.30e-81
membrane	Hs	cellular component	271	3.30e-81
kinase activity	Hs	molecular function	271	3.30e-81
transferase activity	Hs	molecular function	271	3.30e-81
Ras GTPase binding	Hs	molecular function	271	3.30e-81
mitogen-activated protein kinase kinase binding	Hs	molecular function	271	3.30e-81
identical protein binding	Hs	molecular function	271	3.30e-81
neuron projection	Hs	cellular component	271	3.30e-81
intracellular membrane-bounded organelle	Hs	cellular component	271	3.30e-81
cell body	Hs	cellular component	271	3.30e-81
metal ion binding	Hs	molecular function	271	3.30e-81
protein heterodimerization activity	Hs	molecular function	271	3.30e-81

GO Term	Analysis	Type	e-value
protein kinase activity	Pfam	molecular function	4.3E-27
signal transducer activity, downstream of receptor	Pfam	molecular function	3.2E-6
ATP binding	ProSiteProfiles	molecular function	22.803
protein phosphorylation	Pfam	biological process	4.3E-27
signal transduction	Pfam	biological process	3.2E-6
intracellular signal transduction	CDD	biological process	1.41931E-11