IPR Term	Analysis	Definition
Prot_kinase_dom	Pfam	Protein kinase domain
Protein_kinase_ATP_BS	ProSitePatterns	Protein kinase, ATP binding site
Kinase-like_dom_sf	SUPERFAMILY	Protein kinase-like domain superfamily
Prot_kinase_dom	ProSiteProfiles	Protein kinase domain
Prot_kinase_dom	SMART	Protein kinase domain
Ser/Thr_kinase_AS	ProSitePatterns	Serine/threonine-protein kinase, active site

GO Term	Annotation Origin	Type
nucleotide binding	Orthology	molecular function
protein kinase activity	Orthology	molecular function
protein serine/threonine kinase activity	Orthology	molecular function
protein binding	Orthology	molecular function
ATP binding	Orthology	molecular function
extracellular region	Orthology	cellular component
nucleus	Orthology	cellular component
cytoplasm	Orthology	cellular component
mitochondrion	Orthology	cellular component
early endosome	Orthology	cellular component
endoplasmic reticulum	Orthology	cellular component
Golgi apparatus	Orthology	cellular component
microtubule organizing center	Orthology	cellular component
cytosol	Orthology	cellular component
cytoskeleton	Orthology	cellular component
microtubule	Orthology	cellular component
plasma membrane	Orthology	cellular component
focal adhesion	Orthology	cellular component
protein phosphorylation	Orthology	biological process
chemotaxis	Orthology	biological process
signal transduction	Orthology	biological process
heart development	Orthology	biological process
protein C-terminus binding	Orthology	molecular function
negative regulation of cell proliferation	Orthology	biological process
positive regulation of gene expression	Orthology	biological process
negative regulation of gene expression	Orthology	biological process
membrane	Orthology	cellular component
kinase activity	Orthology	molecular function
phosphorylation	Orthology	biological process
transferase activity	Orthology	molecular function
neuron differentiation	Orthology	biological process
regulation of apoptotic process	Orthology	biological process
positive regulation of transcription, DNA-templated	Orthology	biological process
metal ion binding	Orthology	molecular function
protein N-terminus binding	Orthology	molecular function
perinuclear region of cytoplasm	Orthology	cellular component
cell motility	Orthology	biological process
extracellular exosome	Orthology	cellular component
intracellular signal transduction	Orthology	biological process
positive regulation of catalytic activity	Orthology	biological process
positive regulation of signal transduction	Orthology	biological process
regulation of cellular metabolic process	Orthology	biological process
endosome	Orthology	cellular component
intracellular organelle part	Orthology	cellular component
whole membrane	Orthology	cellular component
peroxisome	Orthology	cellular component
bounding membrane of organelle	Orthology	cellular component
cell junction	Orthology	cellular component
plasma membrane part	Orthology	cellular component
animal organ development	Orthology	biological process
cell differentiation	Orthology	biological process
enzyme activator activity	Orthology	molecular function
protein kinase binding	Orthology	molecular function
immune system process	Orthology	biological process
axon development	Orthology	biological process
cellular response to stress	Orthology	biological process
response to wounding	Orthology	biological process
axonogenesis	Orthology	biological process
head development	Orthology	biological process
cytoskeletal part	Blast	cellular component
microtubule cytoskeleton	Blast	cellular component

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type
MAPK cascade	Hs	biological process
nucleotide binding	Hs	molecular function
activation of MAPK activity	Hs	biological process
regulation of protein phosphorylation	Hs	biological process
protein kinase activity	Hs	molecular function
protein serine/threonine kinase activity	Hs	molecular function
MAP kinase kinase activity	Hs	molecular function
protein serine/threonine/tyrosine kinase activity	Hs	molecular function
protein tyrosine kinase activity	Hs	molecular function
signal transducer, downstream of receptor, with protein tyrosine phosphatase activity	Hs	molecular function
protein binding	Hs	molecular function
ATP binding	Hs	molecular function
extracellular region	Hs	cellular component
nucleus	Hs	cellular component
cytoplasm	Hs	cellular component
mitochondrion	Hs	cellular component
early endosome	Hs	cellular component
late endosome	Hs	cellular component
peroxisomal membrane	Hs	cellular component
endoplasmic reticulum	Hs	cellular component
Golgi apparatus	Hs	cellular component
microtubule organizing center	Hs	cellular component
cytosol	Hs	cellular component
cytoskeleton	Hs	cellular component
microtubule	Hs	cellular component
plasma membrane	Hs	cellular component
cell-cell junction	Hs	cellular component
focal adhesion	Hs	cellular component
protein phosphorylation	Hs	biological process
chemotaxis	Hs	biological process
cell cycle arrest	Hs	biological process
signal transduction	Hs	biological process
regulation of mitotic cell cycle	Hs	biological process
heart development	Hs	biological process
protein C-terminus binding	Hs	molecular function
negative regulation of cell proliferation	Hs	biological process
cytoplasmic side of plasma membrane	Hs	cellular component
positive regulation of gene expression	Hs	biological process
negative regulation of gene expression	Hs	biological process
membrane	Hs	cellular component
kinase activity	Hs	molecular function
phosphorylation	Hs	biological process
transferase activity	Hs	molecular function
peptidyl-threonine phosphorylation	Hs	biological process
peptidyl-tyrosine phosphorylation	Hs	biological process
PDZ domain binding	Hs	molecular function
neuron differentiation	Hs	biological process
keratinocyte differentiation	Hs	biological process
thyroid gland development	Hs	biological process
regulation of apoptotic process	Hs	biological process
protein serine/threonine kinase activator activity	Hs	molecular function
positive regulation of cell differentiation	Hs	biological process
positive regulation of transcription, DNA-templated	Hs	biological process
metal ion binding	Hs	molecular function
protein N-terminus binding	Hs	molecular function
perinuclear region of cytoplasm	Hs	cellular component
thymus development	Hs	biological process
regulation of axon regeneration	Hs	biological process
cell motility	Hs	biological process
positive regulation of axonogenesis	Hs	biological process
face development	Hs	biological process
extracellular exosome	Hs	cellular component
positive regulation of ERK1 and ERK2 cascade	Hs	biological process
positive regulation of protein serine/threonine kinase activity	Hs	biological process
cellular senescence	Hs	biological process
scaffold protein binding	Hs	molecular function

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type	Score	E-value
nucleotide binding	Hs	molecular function	456	1.28e-160
protein kinase activity	Hs	molecular function	456	1.28e-160
protein serine/threonine kinase activity	Hs	molecular function	456	1.28e-160
MAP kinase kinase activity	Hs	molecular function	456	1.28e-160
protein serine/threonine/tyrosine kinase activity	Hs	molecular function	456	1.28e-160
protein tyrosine kinase activity	Hs	molecular function	456	1.28e-160
signal transducer, downstream of receptor, with protein tyrosine phosphatase activity	Hs	molecular function	456	1.28e-160
protein binding	Hs	molecular function	456	1.28e-160
ATP binding	Hs	molecular function	456	1.28e-160
extracellular region	Hs	cellular component	444	9.56e-156
nucleus	Hs	cellular component	456	1.28e-160
cytoplasm	Hs	cellular component	456	1.28e-160
mitochondrion	Hs	cellular component	456	1.28e-160
early endosome	Hs	cellular component	456	1.28e-160
late endosome	Hs	cellular component	456	1.28e-160
peroxisomal membrane	Hs	cellular component	444	9.56e-156
endoplasmic reticulum	Hs	cellular component	456	1.28e-160
Golgi apparatus	Hs	cellular component	456	1.28e-160
microtubule organizing center	Hs	cellular component	456	1.28e-160
spindle	Hs	cellular component	253	2.63e-80
cytosol	Hs	cellular component	456	1.28e-160
cytoskeleton	Hs	cellular component	456	1.28e-160
microtubule	Hs	cellular component	444	9.56e-156
plasma membrane	Hs	cellular component	456	1.28e-160
cell-cell junction	Hs	cellular component	444	9.56e-156
focal adhesion	Hs	cellular component	456	1.28e-160
protein C-terminus binding	Hs	molecular function	456	1.28e-160
cytoplasmic side of plasma membrane	Hs	cellular component	444	9.56e-156
membrane	Hs	cellular component	456	1.28e-160
kinase activity	Hs	molecular function	456	1.28e-160
transferase activity	Hs	molecular function	456	1.28e-160
PDZ domain binding	Hs	molecular function	444	9.56e-156
protein serine/threonine kinase activator activity	Hs	molecular function	456	1.28e-160
metal ion binding	Hs	molecular function	444	9.56e-156
protein N-terminus binding	Hs	molecular function	456	1.28e-160
perinuclear region of cytoplasm	Hs	cellular component	444	9.56e-156
extracellular exosome	Hs	cellular component	456	1.28e-160
scaffold protein binding	Hs	molecular function	456	1.28e-160

GO Term	Analysis	Type	e-value
protein kinase activity	SMART	molecular function	8.2E-76
ATP binding	SMART	molecular function	8.2E-76
protein phosphorylation	SMART	biological process	8.2E-76