IPR Term	Analysis	Definition
THDP-binding	SUPERFAMILY	Thiamin diphosphate-binding fold
DH_E1	Pfam	Dehydrogenase, E1 component

GO Term	Annotation Origin	Type
protein binding	Orthology	molecular function
nucleus	Orthology	cellular component
nucleolus	Orthology	cellular component
mitochondrion	Orthology	cellular component
mitochondrial matrix	Orthology	cellular component
metabolic process	Orthology	biological process
myelin sheath	Orthology	cellular component
intracellular membrane-bounded organelle	Orthology	cellular component
oxidation-reduction process	Orthology	biological process
catalytic activity	Orthology	molecular function
organic substance metabolic process	Orthology	biological process
phosphate-containing compound metabolic process	Orthology	biological process
amide biosynthetic process	Orthology	biological process
cellular metabolic process	Orthology	biological process
transferase activity	Orthology	molecular function
cytoplasmic part	Orthology	cellular component
macromolecular complex	Orthology	cellular component

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type
pyruvate dehydrogenase activity	Hs	molecular function
pyruvate dehydrogenase (acetyl-transferring) activity	Hs	molecular function
protein binding	Hs	molecular function
nucleus	Hs	cellular component
nucleolus	Hs	cellular component
mitochondrion	Hs	cellular component
mitochondrial matrix	Hs	cellular component
carbohydrate metabolic process	Hs	biological process
glucose metabolic process	Hs	biological process
acetyl-CoA biosynthetic process from pyruvate	Hs	biological process
pyruvate metabolic process	Hs	biological process
tricarboxylic acid cycle	Hs	biological process
metabolic process	Hs	biological process
oxidoreductase activity	Hs	molecular function
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	Hs	molecular function
pyruvate dehydrogenase (NAD+) activity	Hs	molecular function
myelin sheath	Hs	cellular component
intracellular membrane-bounded organelle	Hs	cellular component
pyruvate dehydrogenase complex	Hs	cellular component
oxidation-reduction process	Hs	biological process

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type	Score	E-value
alpha-ketoacid dehydrogenase activity	Hs	molecular function	115	3.10e-28
3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity	Hs	molecular function	115	3.10e-28
pyruvate dehydrogenase activity	Hs	molecular function	339	2.92e-114
pyruvate dehydrogenase (acetyl-transferring) activity	Hs	molecular function	353	1.66e-120
protein binding	Hs	molecular function	339	2.92e-114
nucleus	Hs	cellular component	353	1.66e-120
nucleolus	Hs	cellular component	353	1.66e-120
mitochondrion	Hs	cellular component	353	1.66e-120
mitochondrial matrix	Hs	cellular component	353	1.66e-120
oxidoreductase activity	Hs	molecular function	353	1.66e-120
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	Hs	molecular function	353	1.66e-120
pyruvate dehydrogenase (NAD+) activity	Hs	molecular function	353	1.66e-120
myelin sheath	Hs	cellular component	339	2.92e-114
intracellular membrane-bounded organelle	Hs	cellular component	353	1.66e-120
pyruvate dehydrogenase complex	Hs	cellular component	353	1.66e-120

GO Term	Analysis	Type	e-value
metabolic process	Pfam	biological process	2.7E-94
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	Pfam	molecular function	2.7E-94