IPR Term	Analysis	Definition
EST1	Pfam	Telomerase activating protein Est1
DNA/RNA-bd_Est1-type	Pfam	DNA/RNA-binding domain, Est1-type
TPR-like_helical_dom_sf	SUPERFAMILY	Tetratricopeptide-like helical domain superfamily

GO Term	Annotation Origin	Type
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	Orthology	biological process
DNA binding	Blast	molecular function
RNA binding	Orthology	molecular function
protein binding	Orthology	molecular function
nucleus	Orthology	cellular component
nucleolus	Blast	cellular component
cytoplasm	Orthology	cellular component
cytosol	Orthology	cellular component
hydrolase activity	Orthology	molecular function
ubiquitin protein ligase binding	Orthology	molecular function
metal ion binding	Blast	molecular function
RNA metabolic process	Orthology	biological process
nuclear part	Orthology	cellular component
macromolecular complex	Orthology	cellular component
intracellular protein transport	Orthology	biological process
gene expression	Orthology	biological process
organelle organization	Orthology	biological process
DNA metabolic process	Orthology	biological process
transferase activity, transferring phosphorus-containing groups	Orthology	molecular function
dephosphorylation	Orthology	biological process
regulation of cellular metabolic process	Orthology	biological process
sequence-specific DNA binding	Orthology	molecular function
enzyme binding	Orthology	molecular function
macromolecular complex binding	Orthology	molecular function
RNA catabolic process	Orthology	biological process
regulation of gene expression	Orthology	biological process
intracellular organelle part	Blast	cellular component
intracellular non-membrane-bounded organelle	Blast	cellular component
cytoskeleton	Blast	cellular component

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	Hs	biological process
ribonuclease activity	Hs	molecular function
protein binding	Hs	molecular function
nucleus	Hs	cellular component
telomerase holoenzyme complex	Hs	cellular component
cytoplasm	Hs	cellular component
cytosol	Hs	cellular component
mRNA export from nucleus	Hs	biological process
ubiquitin protein ligase binding	Hs	molecular function
regulation of telomere maintenance via telomerase	Hs	biological process
regulation of dephosphorylation	Hs	biological process
telomeric DNA binding	Hs	molecular function
histone deacetylase binding	Hs	molecular function
ribonucleoprotein complex binding	Hs	molecular function
regulation of RNA stability	Hs	biological process
protein phosphatase 2A binding	Hs	molecular function
telomerase RNA binding	Hs	molecular function
DNA polymerase binding	Hs	molecular function
RNA phosphodiester bond hydrolysis	Hs	biological process

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type	Score	E-value
telomerase catalytic core complex	Hs	cellular component	54.7	2.65e-07
chromosome, telomeric region	Hs	cellular component	54.7	2.65e-07
DNA binding	Hs	molecular function	54.7	2.65e-07
RNA binding	Hs	molecular function	54.7	2.65e-07
nuclease activity	Hs	molecular function	54.7	2.65e-07
endonuclease activity	Hs	molecular function	54.7	2.65e-07
endoribonuclease activity	Hs	molecular function	54.7	2.65e-07
ribonuclease activity	Hs	molecular function	259	2.73e-73
protein binding	Hs	molecular function	259	2.73e-73
nucleus	Hs	cellular component	259	2.73e-73
chromosome	Hs	cellular component	54.7	2.65e-07
telomerase holoenzyme complex	Hs	cellular component	259	2.73e-73
nucleolus	Hs	cellular component	54.7	2.65e-07
cytoplasm	Hs	cellular component	259	2.73e-73
cytosol	Hs	cellular component	259	2.73e-73
hydrolase activity	Hs	molecular function	54.7	2.65e-07
ubiquitin protein ligase binding	Hs	molecular function	259	2.73e-73
exon-exon junction complex	Hs	cellular component	54.7	2.65e-07
telomeric DNA binding	Hs	molecular function	259	2.73e-73
histone deacetylase binding	Hs	molecular function	259	2.73e-73
ribonucleoprotein complex binding	Hs	molecular function	259	2.73e-73
intermediate filament cytoskeleton	Hs	cellular component	65.1	1.51e-10
metal ion binding	Hs	molecular function	54.7	2.65e-07
protein phosphatase 2A binding	Hs	molecular function	259	2.73e-73
telomerase RNA binding	Hs	molecular function	259	2.73e-73
DNA polymerase binding	Hs	molecular function	259	2.73e-73

GO Term	Analysis	Type	e-value
protein binding	SUPERFAMILY	molecular function	7.96E-46