IPR Term	Analysis	Definition
Keratin_I	PRINTS	Keratin, type I
OMP_efflux	Pfam	Outer membrane efflux protein
IF	PANTHER	Intermediate filament protein
Intermediate_filament_CS	ProSitePatterns	Intermediate filament protein, conserved site

GO Term	Annotation Origin	Type
structural molecule activity	Orthology	molecular function
protein binding	Orthology	molecular function
nucleus	Orthology	cellular component
cytoplasm	Orthology	cellular component
peroxisome	Orthology	cellular component
cytosol	Orthology	cellular component
cytoskeleton	Orthology	cellular component
plasma membrane	Orthology	cellular component
focal adhesion	Orthology	cellular component
protein C-terminus binding	Orthology	molecular function
cytoskeletal protein binding	Orthology	molecular function
positive regulation of gene expression	Orthology	biological process
membrane	Orthology	cellular component
cytokine-mediated signaling pathway	Orthology	biological process
cell leading edge	Orthology	cellular component
identical protein binding	Orthology	molecular function
cell projection	Orthology	cellular component
neuron projection	Orthology	cellular component
extracellular exosome	Orthology	cellular component
transmembrane transport	InterProScan	biological process
integrin binding	Orthology	molecular function
extracellular space	Orthology	cellular component
intracellular	Orthology	cellular component
nucleoplasm	Orthology	cellular component
lysosome	Orthology	cellular component
multicellular organism development	Orthology	biological process
nervous system development	Orthology	biological process
microtubule binding	Orthology	molecular function
response to wounding	Orthology	biological process
response to organic substance	Orthology	biological process
kinase binding	Orthology	molecular function
cell differentiation	Orthology	biological process
extracellular matrix organization	Orthology	biological process
axon	Orthology	cellular component
nuclear membrane	Orthology	cellular component
locomotion	Orthology	biological process
myelin sheath	Orthology	cellular component
cell body	Orthology	cellular component
protein heterodimerization activity	Orthology	molecular function
neuron projection morphogenesis	Orthology	biological process
axon development	Orthology	biological process
regulation of molecular function	Orthology	biological process
RNA binding	Orthology	molecular function
organelle organization	Orthology	biological process
macromolecular complex	Orthology	cellular component
cytoskeletal part	Orthology	cellular component
cell junction	Orthology	cellular component
adherens junction	Orthology	cellular component
neuron projection development	Orthology	biological process
cell development	Orthology	biological process
neurogenesis	Orthology	biological process
central nervous system development	Orthology	biological process
organelle part	Orthology	cellular component
cytoplasmic part	Orthology	cellular component
intracellular non-membrane-bounded organelle	Orthology	cellular component
synapse	Orthology	cellular component
mRNA catabolic process	Orthology	biological process
cytoplasmic vesicle	Orthology	cellular component
cell surface receptor signaling pathway	Orthology	biological process
innate immune response	Orthology	biological process
macromolecular complex binding	Orthology	molecular function
intracellular signal transduction	Orthology	biological process
protein phosphorylation	Orthology	biological process
microtubule-based process	Orthology	biological process
enzyme binding	Orthology	molecular function
molecular function regulator	Orthology	molecular function
cell projection part	Orthology	cellular component
microtubule-based movement	Orthology	biological process
intracellular transport	Orthology	biological process
animal organ development	Orthology	biological process
brain development	Orthology	biological process
cellular response to stress	Orthology	biological process
negative regulation of apoptotic process	Orthology	biological process
axonogenesis	Orthology	biological process
nervous system process	Orthology	biological process
generation of neurons	Orthology	biological process
positive regulation of cell proliferation	Orthology	biological process
chemical synaptic transmission	Orthology	biological process
plasma membrane region	Orthology	cellular component
intracellular part	Orthology	cellular component
neuron part	Orthology	cellular component
membrane part	Orthology	cellular component
lysosomal membrane	Orthology	cellular component

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type
double-stranded RNA binding	Hs	molecular function
structural molecule activity	Hs	molecular function
structural constituent of cytoskeleton	Hs	molecular function
structural constituent of eye lens	Hs	molecular function
protein binding	Hs	molecular function
nucleus	Hs	cellular component
cytoplasm	Hs	cellular component
peroxisome	Hs	cellular component
cytosol	Hs	cellular component
polysome	Hs	cellular component
cytoskeleton	Hs	cellular component
intermediate filament	Hs	cellular component
plasma membrane	Hs	cellular component
cell-cell junction	Hs	cellular component
fascia adherens	Hs	cellular component
focal adhesion	Hs	cellular component
muscle contraction	Hs	biological process
cytoskeleton organization	Hs	biological process
regulation of heart contraction	Hs	biological process
protein C-terminus binding	Hs	molecular function
cytoskeletal protein binding	Hs	molecular function
positive regulation of gene expression	Hs	biological process
negative regulation of neuron projection development	Hs	biological process
astrocyte development	Hs	biological process
intercalated disc	Hs	cellular component
membrane	Hs	cellular component
viral process	Hs	biological process
cytokine-mediated signaling pathway	Hs	biological process
protein domain specific binding	Hs	molecular function
Z disc	Hs	cellular component
intracellular ribonucleoprotein complex	Hs	cellular component
cell leading edge	Hs	cellular component
neuromuscular junction	Hs	cellular component
sarcolemma	Hs	cellular component
identical protein binding	Hs	molecular function
cell projection	Hs	cellular component
neuron projection	Hs	cellular component
contractile fiber	Hs	cellular component
regulation of mRNA stability	Hs	biological process
type III intermediate filament	Hs	cellular component
intermediate filament organization	Hs	biological process
intermediate filament cytoskeleton	Hs	cellular component
phagocytic vesicle	Hs	cellular component
positive regulation of translation	Hs	biological process
SMAD protein signal transduction	Hs	biological process
extracellular exosome	Hs	cellular component
cellular response to interferon-gamma	Hs	biological process
scaffold protein binding	Hs	molecular function
cardiac myofibril	Hs	cellular component
keratin filament binding	Hs	molecular function
MAPK cascade	Hs	biological process
microtubule cytoskeleton organization	Hs	biological process
Ras guanyl-nucleotide exchange factor activity	Hs	molecular function
integrin binding	Hs	molecular function
extracellular space	Hs	cellular component
intracellular	Hs	cellular component
nucleoplasm	Hs	cellular component
lysosome	Hs	cellular component
neurofilament	Hs	cellular component
multicellular organism development	Hs	biological process
nervous system development	Hs	biological process
microtubule binding	Hs	molecular function
anterograde axonal transport	Hs	biological process
retrograde axonal transport	Hs	biological process
response to wounding	Hs	biological process
response to toxic substance	Hs	biological process
response to organic substance	Hs	biological process
axonal transport of mitochondrion	Hs	biological process
kinase binding	Hs	molecular function
spinal cord development	Hs	biological process
cerebral cortex development	Hs	biological process
cell differentiation	Hs	biological process
extracellular matrix organization	Hs	biological process
axon	Hs	cellular component
growth cone	Hs	cellular component
protein binding, bridging	Hs	molecular function
neuron projection regeneration	Hs	biological process
nuclear membrane	Hs	cellular component
TSC1-TSC2 complex	Hs	cellular component
cytoplasmic ribonucleoprotein granule	Hs	cellular component
locomotion	Hs	biological process
myelin sheath	Hs	cellular component
phospholipase binding	Hs	molecular function
response to peptide hormone	Hs	biological process
negative regulation of neuron apoptotic process	Hs	biological process
cell body	Hs	cellular component
intermediate filament cytoskeleton organization	Hs	biological process
protein heterodimerization activity	Hs	molecular function
neuron projection morphogenesis	Hs	biological process
positive regulation of axonogenesis	Hs	biological process
neuromuscular process controlling balance	Hs	biological process
protein polymerization	Hs	biological process
neurofilament cytoskeleton organization	Hs	biological process
positive regulation of glial cell proliferation	Hs	biological process
long-term synaptic potentiation	Hs	biological process
axon development	Hs	biological process
regulation of molecular function	Hs	biological process
glial cell projection	Hs	cellular component
neurofibrillary tangle	Hs	cellular component
astrocyte projection	Hs	cellular component
astrocyte end-foot	Hs	cellular component
cytoplasmic side of lysosomal membrane	Hs	cellular component
axon cytoplasm	Hs	cellular component

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type	Score	E-value
double-stranded RNA binding	Hs	molecular function	353	1.29e-117
structural molecule activity	Hs	molecular function	353	1.29e-117
structural constituent of cytoskeleton	Hs	molecular function	353	1.29e-117
structural constituent of eye lens	Hs	molecular function	353	1.29e-117
protein binding	Hs	molecular function	353	1.29e-117
nucleus	Hs	cellular component	290	9.81e-93
cytoplasm	Hs	cellular component	353	1.29e-117
peroxisome	Hs	cellular component	353	1.29e-117
cytosol	Hs	cellular component	353	1.29e-117
polysome	Hs	cellular component	353	1.29e-117
cytoskeleton	Hs	cellular component	353	1.29e-117
intermediate filament	Hs	cellular component	353	1.29e-117
plasma membrane	Hs	cellular component	353	1.29e-117
cell-cell junction	Hs	cellular component	290	9.81e-93
fascia adherens	Hs	cellular component	290	9.81e-93
focal adhesion	Hs	cellular component	353	1.29e-117
protein C-terminus binding	Hs	molecular function	353	1.29e-117
cytoskeletal protein binding	Hs	molecular function	290	9.81e-93
intercalated disc	Hs	cellular component	290	9.81e-93
membrane	Hs	cellular component	290	9.81e-93
protein domain specific binding	Hs	molecular function	353	1.29e-117
Z disc	Hs	cellular component	290	9.81e-93
intracellular ribonucleoprotein complex	Hs	cellular component	353	1.29e-117
cell leading edge	Hs	cellular component	353	1.29e-117
neuromuscular junction	Hs	cellular component	290	9.81e-93
sarcolemma	Hs	cellular component	290	9.81e-93
identical protein binding	Hs	molecular function	353	1.29e-117
cell projection	Hs	cellular component	353	1.29e-117
neuron projection	Hs	cellular component	353	1.29e-117
contractile fiber	Hs	cellular component	290	9.81e-93
type III intermediate filament	Hs	cellular component	283	2.20e-90
intermediate filament cytoskeleton	Hs	cellular component	290	9.81e-93
phagocytic vesicle	Hs	cellular component	353	1.29e-117
extracellular exosome	Hs	cellular component	353	1.29e-117
scaffold protein binding	Hs	molecular function	353	1.29e-117
cardiac myofibril	Hs	cellular component	290	9.81e-93
keratin filament binding	Hs	molecular function	353	1.29e-117

GO Term	Analysis	Type	e-value
structural molecule activity	PANTHER	molecular function	2.2E-136
intermediate filament	PANTHER	cellular component	2.2E-136
efflux transmembrane transporter activity	Pfam	molecular function	8.3E-5
transmembrane transport	Pfam	biological process	8.3E-5