IPR Term	Analysis	Definition
SH3_domain	ProSiteProfiles	SH3 domain
SH3_domain	Pfam	SH3 domain
SH2_dom_sf	Gene3D	SH2 domain superfamily
SH3_domain	SMART	SH3 domain
SH2	SMART	SH2 domain
SH3_domain	PRINTS	SH3 domain
CRK_SH3_N	CDD	CRK, N-terminal SH3 domain
SH2	PRINTS	SH2 domain
SH2	Pfam	SH2 domain
SH2	ProSiteProfiles	SH2 domain
SH2_dom_sf	SUPERFAMILY	SH2 domain superfamily
SH3-like_dom_sf	SUPERFAMILY	SH3-like domain superfamily

GO Term	Annotation Origin	Type
blood vessel development	Orthology	biological process
RNA binding	Orthology	molecular function
signal transducer activity	Orthology	molecular function
receptor binding	Orthology	molecular function
protein binding	Orthology	molecular function
nucleus	Orthology	cellular component
nucleoplasm	Orthology	cellular component
cytoplasm	Orthology	cellular component
endosome	Orthology	cellular component
cytosol	Orthology	cellular component
plasma membrane	Orthology	cellular component
regulation of transcription from RNA polymerase II promoter	Orthology	biological process
heart development	Orthology	biological process
cytoskeletal protein binding	Orthology	molecular function
positive regulation of cell proliferation	Orthology	biological process
regulation of signal transduction	Orthology	biological process
positive regulation of signal transduction	Orthology	biological process
membrane	Orthology	cellular component
cytokine-mediated signaling pathway	Orthology	biological process
enzyme binding	Orthology	molecular function
macromolecular complex	Orthology	cellular component
intracellular signal transduction	Orthology	biological process
identical protein binding	Orthology	molecular function
regulation of GTPase activity	Orthology	biological process
membrane raft	Orthology	cellular component
extracellular exosome	Orthology	cellular component
positive regulation of catalytic activity	Orthology	biological process
protein serine/threonine kinase activity	Orthology	molecular function
cellular response to stress	Orthology	biological process
protein phosphorylation	Orthology	biological process
small GTPase mediated signal transduction	Orthology	biological process
multicellular organism development	Orthology	biological process
cell morphogenesis	Orthology	biological process
animal organ development	Orthology	biological process
anatomical structure morphogenesis	Orthology	biological process
cytoskeleton	Orthology	cellular component
organelle organization	Orthology	biological process
response to oxidative stress	Orthology	biological process
regulation of molecular function	Orthology	biological process
cell adhesion molecule binding	Orthology	molecular function
cell surface receptor signaling pathway	Orthology	biological process
immune system process	Orthology	biological process
cellular response to organic substance	Orthology	biological process
cell morphogenesis involved in differentiation	Orthology	biological process
cell adhesion	Orthology	biological process
response to organic substance	Orthology	biological process
protein kinase binding	Orthology	molecular function
cell motility	Orthology	biological process
protein kinase activity	Blast	molecular function
intracellular part	Blast	cellular component
plasma membrane part	Blast	cellular component

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type
activation of MAPKK activity	Hs	biological process
blood vessel development	Hs	biological process
phosphotyrosine residue binding	Hs	molecular function
response to yeast	Hs	biological process
RNA binding	Hs	molecular function
signal transducer activity	Hs	molecular function
SH3/SH2 adaptor activity	Hs	molecular function
insulin-like growth factor receptor binding	Hs	molecular function
protein binding	Hs	molecular function
nucleus	Hs	cellular component
nucleoplasm	Hs	cellular component
cytoplasm	Hs	cellular component
endosome	Hs	cellular component
cytosol	Hs	cellular component
plasma membrane	Hs	cellular component
regulation of transcription from RNA polymerase II promoter	Hs	biological process
JNK cascade	Hs	biological process
Ras protein signal transduction	Hs	biological process
pattern specification process	Hs	biological process
heart development	Hs	biological process
cytoskeletal protein binding	Hs	molecular function
positive regulation of cell proliferation	Hs	biological process
regulation of cell shape	Hs	biological process
animal organ morphogenesis	Hs	biological process
anterior/posterior pattern specification	Hs	biological process
regulation of signal transduction	Hs	biological process
positive regulation of signal transduction	Hs	biological process
actin cytoskeleton	Hs	cellular component
membrane	Hs	cellular component
SH3 domain binding	Hs	molecular function
cytokine-mediated signaling pathway	Hs	biological process
enzyme binding	Hs	molecular function
protein domain specific binding	Hs	molecular function
protein binding, bridging	Hs	molecular function
regulation of actin cytoskeleton organization	Hs	biological process
macromolecular complex	Hs	cellular component
intracellular signal transduction	Hs	biological process
SH2 domain binding	Hs	molecular function
response to hydrogen peroxide	Hs	biological process
identical protein binding	Hs	molecular function
regulation of GTPase activity	Hs	biological process
regulation of protein binding	Hs	biological process
protein self-association	Hs	molecular function
membrane raft	Hs	cellular component
cadherin binding	Hs	molecular function
protein phosphorylated amino acid binding	Hs	molecular function
ephrin receptor binding	Hs	molecular function
vascular endothelial growth factor receptor signaling pathway	Hs	biological process
ephrin receptor signaling pathway	Hs	biological process
thymus development	Hs	biological process
parathyroid gland development	Hs	biological process
extracellular exosome	Hs	cellular component
cellular response to transforming growth factor beta stimulus	Hs	biological process
scaffold protein binding	Hs	molecular function
positive regulation of substrate adhesion-dependent cell spreading	Hs	biological process
response to peptide	Hs	biological process
protein tyrosine kinase binding	Hs	molecular function
negative regulation of cell motility	Hs	biological process

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type	Score	E-value
phosphotyrosine residue binding	Hs	molecular function	268	1.32e-89
RNA binding	Hs	molecular function	268	1.32e-89
non-membrane spanning protein tyrosine kinase activity	Hs	molecular function	95.5	1.58e-23
signal transducer activity	Hs	molecular function	268	1.32e-89
SH3/SH2 adaptor activity	Hs	molecular function	268	1.32e-89
receptor binding	Hs	molecular function	95.5	1.58e-23
insulin-like growth factor receptor binding	Hs	molecular function	256	7.42e-85
protein binding	Hs	molecular function	268	1.32e-89
nucleus	Hs	cellular component	256	7.42e-85
nucleoplasm	Hs	cellular component	268	1.32e-89
cytoplasm	Hs	cellular component	268	1.32e-89
endosome	Hs	cellular component	268	1.32e-89
cytosol	Hs	cellular component	268	1.32e-89
plasma membrane	Hs	cellular component	256	7.42e-85
cytoskeletal protein binding	Hs	molecular function	256	7.42e-85
actin cytoskeleton	Hs	cellular component	256	7.42e-85
membrane	Hs	cellular component	256	7.42e-85
SH3 domain binding	Hs	molecular function	256	7.42e-85
enzyme binding	Hs	molecular function	256	7.42e-85
protein domain specific binding	Hs	molecular function	256	7.42e-85
protein binding, bridging	Hs	molecular function	256	7.42e-85
extrinsic component of cytoplasmic side of plasma membrane	Hs	cellular component	95.5	1.58e-23
macromolecular complex	Hs	cellular component	256	7.42e-85
SH2 domain binding	Hs	molecular function	256	7.42e-85
identical protein binding	Hs	molecular function	268	1.32e-89
protein self-association	Hs	molecular function	256	7.42e-85
membrane raft	Hs	cellular component	256	7.42e-85
cadherin binding	Hs	molecular function	268	1.32e-89
protein phosphorylated amino acid binding	Hs	molecular function	256	7.42e-85
ephrin receptor binding	Hs	molecular function	256	7.42e-85
extracellular exosome	Hs	cellular component	268	1.32e-89
scaffold protein binding	Hs	molecular function	256	7.42e-85
protein tyrosine kinase binding	Hs	molecular function	256	7.42e-85

GO Term	Analysis	Type	e-value
protein binding	SUPERFAMILY	molecular function	1.58E-21