IPR Term	Analysis	Definition
HLH_DNA-bd_sf	Gene3D	Helix-loop-helix DNA-binding domain superfamily
MiT/TFE_N	Pfam	MiT/TFE transcription factors, N-terminal
TFEB	PANTHER	Transcription factor EB
bHLH_dom	SMART	Myc-type, basic helix-loop-helix (bHLH) domain
bHLH_dom	ProSiteProfiles	Myc-type, basic helix-loop-helix (bHLH) domain
bHLH_dom	CDD	Myc-type, basic helix-loop-helix (bHLH) domain
HLH_DNA-bd_sf	SUPERFAMILY	Helix-loop-helix DNA-binding domain superfamily
bHLH_dom	Pfam	Myc-type, basic helix-loop-helix (bHLH) domain

GO Term	Annotation Origin	Type
negative regulation of transcription from RNA polymerase II promoter	Orthology	biological process
RNA polymerase II core promoter proximal region sequence-specific DNA binding	Orthology	molecular function
RNA polymerase II transcription factor activity, sequence-specific DNA binding	Orthology	molecular function
immune system process	Orthology	biological process
DNA binding	Orthology	molecular function
chromatin binding	Orthology	molecular function
transcription factor activity, sequence-specific DNA binding	Orthology	molecular function
protein binding	Orthology	molecular function
nucleus	Orthology	cellular component
nucleoplasm	Orthology	cellular component
cytoplasm	Orthology	cellular component
cytosol	Orthology	cellular component
transcription, DNA-templated	Orthology	biological process
regulation of transcription, DNA-templated	Orthology	biological process
regulation of transcription from RNA polymerase II promoter	Orthology	biological process
transcription from RNA polymerase II promoter	Orthology	biological process
multicellular organism development	Orthology	biological process
regulation of gene expression	Orthology	biological process
positive regulation of gene expression	Orthology	biological process
cell differentiation	Orthology	biological process
macromolecular complex	Orthology	cellular component
regulation of cell proliferation	Orthology	biological process
negative regulation of apoptotic process	Orthology	biological process
transcription regulatory region DNA binding	Orthology	molecular function
positive regulation of transcription, DNA-templated	Orthology	biological process
positive regulation of transcription from RNA polymerase II promoter	Orthology	biological process
protein dimerization activity	Orthology	molecular function
regulation of RNA biosynthetic process	Orthology	biological process
transcription coactivator activity	Orthology	molecular function
transcription corepressor activity	Orthology	molecular function
negative regulation of nucleic acid-templated transcription	Orthology	biological process
immune response	Orthology	biological process
organelle organization	Orthology	biological process
cell surface receptor signaling pathway	Orthology	biological process
cell-cell signaling	Orthology	biological process
protein modification by small protein conjugation	Orthology	biological process
animal organ development	Orthology	biological process
cell adhesion	Orthology	biological process
cellular response to stress	Orthology	biological process

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type
negative regulation of transcription from RNA polymerase II promoter	Hs	biological process
RNA polymerase II core promoter proximal region sequence-specific DNA binding	Hs	molecular function
RNA polymerase II transcription factor activity, sequence-specific DNA binding	Hs	molecular function
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	Hs	molecular function
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding	Hs	molecular function
adaptive immune response	Hs	biological process
immune system process	Hs	biological process
DNA binding	Hs	molecular function
chromatin binding	Hs	molecular function
transcription factor activity, sequence-specific DNA binding	Hs	molecular function
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	Hs	molecular function
protein binding	Hs	molecular function
nucleus	Hs	cellular component
nucleoplasm	Hs	cellular component
cytoplasm	Hs	cellular component
cytosol	Hs	cellular component
transcription, DNA-templated	Hs	biological process
regulation of transcription, DNA-templated	Hs	biological process
regulation of transcription from RNA polymerase II promoter	Hs	biological process
transcription from RNA polymerase II promoter	Hs	biological process
autophagy	Hs	biological process
humoral immune response	Hs	biological process
lysosome organization	Hs	biological process
multicellular organism development	Hs	biological process
regulation of gene expression	Hs	biological process
positive regulation of autophagy	Hs	biological process
positive regulation of gene expression	Hs	biological process
Wnt signaling pathway	Hs	biological process
protein sumoylation	Hs	biological process
cell differentiation	Hs	biological process
osteoclast differentiation	Hs	biological process
melanocyte differentiation	Hs	biological process
macromolecular complex	Hs	cellular component
regulation of cell proliferation	Hs	biological process
camera-type eye development	Hs	biological process
negative regulation of apoptotic process	Hs	biological process
pigmentation	Hs	biological process
transcription regulatory region DNA binding	Hs	molecular function
cell fate commitment	Hs	biological process
regulation of osteoclast differentiation	Hs	biological process
positive regulation of cell adhesion	Hs	biological process
positive regulation of transcription, DNA-templated	Hs	biological process
positive regulation of transcription from RNA polymerase II promoter	Hs	biological process
bone remodeling	Hs	biological process
protein dimerization activity	Hs	molecular function
E-box binding	Hs	molecular function
regulation of RNA biosynthetic process	Hs	biological process
transcription coactivator activity	Hs	molecular function
transcription corepressor activity	Hs	molecular function
cellular response to heat	Hs	biological process
negative regulation of nucleic acid-templated transcription	Hs	biological process

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type	Score	E-value
RNA polymerase II core promoter proximal region sequence-specific DNA binding	Hs	molecular function	212	6.30e-61
RNA polymerase II transcription factor activity, sequence-specific DNA binding	Hs	molecular function	212	6.30e-61
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	Hs	molecular function	212	6.30e-61
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding	Hs	molecular function	183	8.57e-51
DNA binding	Hs	molecular function	212	6.30e-61
chromatin binding	Hs	molecular function	183	8.57e-51
transcription factor activity, sequence-specific DNA binding	Hs	molecular function	212	6.30e-61
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	Hs	molecular function	183	8.57e-51
protein binding	Hs	molecular function	212	6.30e-61
nucleus	Hs	cellular component	212	6.30e-61
nucleoplasm	Hs	cellular component	212	6.30e-61
cytoplasm	Hs	cellular component	182	4.58e-50
cytosol	Hs	cellular component	212	6.30e-61
macromolecular complex	Hs	cellular component	183	8.57e-51
transcription regulatory region DNA binding	Hs	molecular function	212	6.30e-61
protein dimerization activity	Hs	molecular function	212	6.30e-61
E-box binding	Hs	molecular function	183	8.57e-51

GO Term	Analysis	Type	e-value
regulation of transcription, DNA-templated	PANTHER	biological process	2.6E-89
humoral immune response	PANTHER	biological process	2.6E-89
positive regulation of transcription, DNA-templated	PANTHER	biological process	2.6E-89
protein dimerization activity	PANTHER	molecular function	2.6E-89