IPR Term	Analysis	Definition
Small_GTPase	Pfam	Small GTPase superfamily
Small_GTP-bd_dom	TIGRFAM	Small GTP-binding protein domain
P-loop_NTPase	SUPERFAMILY	P-loop containing nucleoside triphosphate hydrolase
Small_GTPase_Ras	ProSiteProfiles	Small GTPase superfamily, Ras type
Small_GTPase_Ras	PANTHER	Small GTPase superfamily, Ras type

GO Term	Annotation Origin	Type
nucleotide binding	Orthology	molecular function
GTPase activity	Orthology	molecular function
protein binding	Orthology	molecular function
GTP binding	Orthology	molecular function
intracellular	Orthology	cellular component
cytoplasm	Orthology	cellular component
endosome	Orthology	cellular component
early endosome	Orthology	cellular component
cytosol	Orthology	cellular component
plasma membrane	Orthology	cellular component
signal transduction	Orthology	biological process
small GTPase mediated signal transduction	Orthology	biological process
nervous system development	Orthology	biological process
cell proliferation	Orthology	biological process
protein transport	Orthology	biological process
membrane	Orthology	cellular component
cell junction	Orthology	cellular component
neuron projection	Orthology	cellular component
myelin sheath	Orthology	cellular component
positive regulation of GTPase activity	Orthology	biological process
macromolecular complex binding	Orthology	molecular function
perinuclear region of cytoplasm	Orthology	cellular component
extracellular exosome	Orthology	cellular component
positive regulation of catalytic activity	Orthology	biological process
intracellular signal transduction	Orthology	biological process
protein serine/threonine kinase activity	Orthology	molecular function
positive regulation of signal transduction	Orthology	biological process
intracellular non-membrane-bounded organelle	Orthology	cellular component
neuron projection development	Orthology	biological process
enzyme binding	Orthology	molecular function
molecular function regulator	Orthology	molecular function
anion binding	Orthology	molecular function
guanyl ribonucleotide binding	Orthology	molecular function
purine ribonucleoside binding	Orthology	molecular function
intracellular part	Orthology	cellular component
macromolecular complex	Orthology	cellular component
cytoplasmic vesicle	Orthology	cellular component
lysosomal membrane	Orthology	cellular component
endomembrane system	Orthology	cellular component
whole membrane	Orthology	cellular component
intracellular organelle part	Orthology	cellular component
bounding membrane of organelle	Orthology	cellular component
cell surface receptor signaling pathway	Orthology	biological process
cellular response to organic substance	Orthology	biological process
protein kinase activity	Orthology	molecular function
organic substance transport	Orthology	biological process
transmembrane transport	Orthology	biological process
regulation of signaling	Orthology	biological process
cell-cell signaling	Orthology	biological process
cell development	Orthology	biological process
protein phosphorylation	Orthology	biological process
cell	Orthology	cellular component
organelle organization	Orthology	biological process
synapse part	Orthology	cellular component
intracellular transport	Orthology	biological process
neuron part	Orthology	cellular component
membrane organization	Orthology	biological process
chemical synaptic transmission	Orthology	biological process

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type
nucleotide binding	Hs	molecular function
activation of MAPKK activity	Hs	biological process
GTPase activity	Hs	molecular function
protein binding	Hs	molecular function
GTP binding	Hs	molecular function
intracellular	Hs	cellular component
cytoplasm	Hs	cellular component
endosome	Hs	cellular component
early endosome	Hs	cellular component
late endosome	Hs	cellular component
lipid droplet	Hs	cellular component
cytosol	Hs	cellular component
plasma membrane	Hs	cellular component
cell-cell junction	Hs	cellular component
signal transduction	Hs	biological process
small GTPase mediated signal transduction	Hs	biological process
nervous system development	Hs	biological process
cell proliferation	Hs	biological process
protein transporter activity	Hs	molecular function
positive regulation of neuron projection development	Hs	biological process
protein transport	Hs	biological process
membrane	Hs	cellular component
Ras GTPase binding	Hs	molecular function
Rap guanyl-nucleotide exchange factor activity	Hs	molecular function
GDP binding	Hs	molecular function
cell junction	Hs	cellular component
guanyl-nucleotide exchange factor complex	Hs	cellular component
Rap protein signal transduction	Hs	biological process
azurophil granule membrane	Hs	cellular component
specific granule membrane	Hs	cellular component
nerve growth factor signaling pathway	Hs	biological process
neuron projection	Hs	cellular component
myelin sheath	Hs	cellular component
positive regulation of GTPase activity	Hs	biological process
macromolecular complex binding	Hs	molecular function
phagocytic vesicle	Hs	cellular component
positive regulation of protein kinase activity	Hs	biological process
positive regulation of glucose import	Hs	biological process
perinuclear region of cytoplasm	Hs	cellular component
regulation of insulin secretion	Hs	biological process
establishment of endothelial barrier	Hs	biological process
extracellular exosome	Hs	cellular component
positive regulation of ERK1 and ERK2 cascade	Hs	biological process
cellular response to glucose stimulus	Hs	biological process
cellular response to organic cyclic compound	Hs	biological process
cellular response to gonadotropin-releasing hormone	Hs	biological process
regulation of cell junction assembly	Hs	biological process
regulation of establishment of cell polarity	Hs	biological process
negative regulation of synaptic vesicle exocytosis	Hs	biological process

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type	Score	E-value
nucleotide binding	Hs	molecular function	315	1.60e-111
GTPase activity	Hs	molecular function	315	1.60e-111
protein binding	Hs	molecular function	315	1.60e-111
GTP binding	Hs	molecular function	315	1.60e-111
intracellular	Hs	cellular component	315	1.60e-111
cytoplasm	Hs	cellular component	315	1.60e-111
endosome	Hs	cellular component	300	9.76e-106
early endosome	Hs	cellular component	300	9.76e-106
late endosome	Hs	cellular component	300	9.76e-106
lipid droplet	Hs	cellular component	315	1.60e-111
cytosol	Hs	cellular component	315	1.60e-111
plasma membrane	Hs	cellular component	315	1.60e-111
cell-cell junction	Hs	cellular component	315	1.60e-111
protein transporter activity	Hs	molecular function	300	9.76e-106
membrane	Hs	cellular component	315	1.60e-111
Ras GTPase binding	Hs	molecular function	300	9.76e-106
Rap guanyl-nucleotide exchange factor activity	Hs	molecular function	300	9.76e-106
GDP binding	Hs	molecular function	315	1.60e-111
cell junction	Hs	cellular component	315	1.60e-111
guanyl-nucleotide exchange factor complex	Hs	cellular component	300	9.76e-106
azurophil granule membrane	Hs	cellular component	315	1.60e-111
specific granule membrane	Hs	cellular component	300	9.76e-106
neuron projection	Hs	cellular component	300	9.76e-106
myelin sheath	Hs	cellular component	300	9.76e-106
macromolecular complex binding	Hs	molecular function	315	1.60e-111
phagocytic vesicle	Hs	cellular component	300	9.76e-106
perinuclear region of cytoplasm	Hs	cellular component	300	9.76e-106
extracellular exosome	Hs	cellular component	315	1.60e-111

GO Term	Analysis	Type	e-value
GTPase activity	CDD	molecular function	5.89395E-118
GTP binding	PANTHER	molecular function	4.5E-104
signal transduction	PANTHER	biological process	4.5E-104
membrane	PANTHER	cellular component	4.5E-104