Gene Card
Best human hits
LRP4; LRP6
Species
Unique Gene ID
Phmamm.g00011254
Gene Model ID
Phmamm.CG.MTP2014.S691.g11254
Location
S691:25819..64773
Transcript Models and Sequences
Phmamm.CG.MTP2014.S691.g11254.01.t
Phmamm.CG.MTP2014.S691.g11254.02.t
AHC0AAA28YD08
Plate: Plate_28_D08
AHC0AAA39YD04
Plate: Plate_39_D04
AHC0AAA57YJ21
Plate: Plate_57_J21
AHC0AAA117YO08
Plate: Plate_117_O08
AHC0AAA123YC12
Plate: Plate_123_C12
AHC0AAA39YD02
Plate: Plate_39_D02
n/a
You can Right Mouse Click on internal nodes, leaves and outside the tree to see multiple options adapted to your selection.
The 'History' button on the left side permits you to see the changes you have made and eventually to go back.
You can Press 'Shift' Key + Left Mouse Click on the leaf's node to access to a gene card in a new window.
You can Press 'Ctrl' Key + Left Mouse Click on nodes to do a multiple selection.
Click here to see how you can interact with this tree
The 'History' button on the left side permits you to see the changes you have made and eventually to go back.
You can Press 'Shift' Key + Left Mouse Click on the leaf's node to access to a gene card in a new window.
You can Press 'Ctrl' Key + Left Mouse Click on nodes to do a multiple selection.

IPR Term | Analysis | Definition |
---|---|---|
LDLR_classB_rpt | Pfam | LDLR class B repeat |
LDrepeatLR_classA_rpt | ProSiteProfiles | Low-density lipoprotein (LDL) receptor class A repeat |
LDL_receptor-like_sf | SUPERFAMILY | LDL receptor-like superfamily |
LDrepeatLR_classA_rpt | CDD | Low-density lipoprotein (LDL) receptor class A repeat |
Growth_fac_rcpt_cys_sf | SUPERFAMILY | Growth factor receptor cysteine-rich domain superfamily |
LDLR_class-A_CS | ProSitePatterns | Low-density lipoprotein (LDL) receptor class A, conserved site |
LDrepeatLR_classA_rpt | Pfam | Low-density lipoprotein (LDL) receptor class A repeat |
6-blade_b-propeller_TolB-like | Gene3D | Six-bladed beta-propeller, TolB-like |
LDLR_classB_rpt | ProSiteProfiles | LDLR class B repeat |
EGF-like_Ca-bd_dom | SMART | EGF-like calcium-binding domain |
LRP4 | PANTHER | Low-density lipoprotein receptor-related protein 4 |
EGF-like_CS | ProSitePatterns | EGF-like, conserved site |
EGF-like_Ca-bd_dom | Pfam | EGF-like calcium-binding domain |
EGF-type_Asp/Asn_hydroxyl_site | ProSitePatterns | EGF-type aspartate/asparagine hydroxylation site |
LDrepeatLR_classA_rpt | SMART | Low-density lipoprotein (LDL) receptor class A repeat |
LDLR_classB_rpt | SMART | LDLR class B repeat |
LDrepeatLR_classA_rpt | PRINTS | Low-density lipoprotein (LDL) receptor class A repeat |
EGF_Ca-bd_CS | ProSitePatterns | EGF-like calcium-binding, conserved site |
EGF-like_dom | SMART | EGF-like domain |
GO Term | Annotation Origin | Type |
---|---|---|
receptor binding | Orthology | molecular function |
calcium ion binding | Orthology | molecular function |
protein binding | Orthology | molecular function |
extracellular region | Blast | cellular component |
early endosome | Blast | cellular component |
endoplasmic reticulum | Blast | cellular component |
Golgi apparatus | Blast | cellular component |
plasma membrane | Orthology | cellular component |
multicellular organism development | Orthology | biological process |
protein localization | Orthology | biological process |
cell surface | Orthology | cellular component |
membrane | Orthology | cellular component |
integral component of membrane | Orthology | cellular component |
cell differentiation | Orthology | biological process |
negative regulation of Wnt signaling pathway | Orthology | biological process |
cytoplasmic vesicle | Blast | cellular component |
identical protein binding | Blast | molecular function |
protein homodimerization activity | Orthology | molecular function |
neuronal cell body | Orthology | cellular component |
membrane raft | Orthology | cellular component |
synapse | Orthology | cellular component |
animal organ development | Orthology | biological process |
anatomical structure development | Orthology | biological process |
regulation of canonical Wnt signaling pathway | Orthology | biological process |
negative regulation of canonical Wnt signaling pathway | Orthology | biological process |
synaptic membrane | Orthology | cellular component |
regulation of cellular metabolic process | Orthology | biological process |
protein phosphorylation | Orthology | biological process |
membrane organization | Orthology | biological process |
organelle organization | Orthology | biological process |
organelle | Orthology | cellular component |
postsynapse | Orthology | cellular component |
neuron part | Orthology | cellular component |
cell surface receptor signaling pathway | Orthology | biological process |
cell-cell signaling | Orthology | biological process |
plasma membrane region | Orthology | cellular component |
macromolecular complex | Orthology | cellular component |
anatomical structure morphogenesis | Orthology | biological process |
regulation of transcription from RNA polymerase II promoter | Orthology | biological process |
cellular response to organic substance | Orthology | biological process |
protein kinase binding | Orthology | molecular function |
transmembrane signaling receptor activity | Orthology | molecular function |
protein localization to membrane | Orthology | biological process |
cell morphogenesis involved in neuron differentiation | Orthology | biological process |
neuron projection morphogenesis | Orthology | biological process |
axonogenesis | Orthology | biological process |
cellular component organization | Orthology | biological process |
nervous system development | Orthology | biological process |
protein oligomerization | Orthology | biological process |
macromolecular complex binding | Blast | molecular function |
kinase activity | Blast | molecular function |
enzyme regulator activity | Blast | molecular function |
transmembrane transport | Blast | biological process |
whole membrane | Blast | cellular component |
intracellular organelle part | Blast | cellular component |
bounding membrane of organelle | Blast | cellular component |
signaling receptor activity | Blast | molecular function |
plasma membrane part | Blast | cellular component |
GO Term | SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae |
Type | Score | E-value |
---|---|---|---|---|
low-density lipoprotein receptor activity | Hs | molecular function | 759 | 0.0 |
receptor binding | Hs | molecular function | 759 | 0.0 |
frizzled binding | Hs | molecular function | 759 | 0.0 |
calcium ion binding | Hs | molecular function | 1236 | 0.0 |
protein binding | Hs | molecular function | 1236 | 0.0 |
extracellular region | Hs | cellular component | 759 | 0.0 |
early endosome | Hs | cellular component | 759 | 0.0 |
endoplasmic reticulum | Hs | cellular component | 759 | 0.0 |
Golgi apparatus | Hs | cellular component | 759 | 0.0 |
plasma membrane | Hs | cellular component | 1236 | 0.0 |
caveola | Hs | cellular component | 759 | 0.0 |
cell surface | Hs | cellular component | 1236 | 0.0 |
postsynaptic density | Hs | cellular component | 1236 | 0.0 |
membrane | Hs | cellular component | 1236 | 0.0 |
integral component of membrane | Hs | cellular component | 1236 | 0.0 |
flotillin complex | Hs | cellular component | 1236 | 0.0 |
Wnt-protein binding | Hs | molecular function | 1236 | 0.0 |
kinase inhibitor activity | Hs | molecular function | 759 | 0.0 |
toxin transporter activity | Hs | molecular function | 759 | 0.0 |
dendrite | Hs | cellular component | 1236 | 0.0 |
receptor tyrosine kinase binding | Hs | molecular function | 1236 | 0.0 |
cytoplasmic vesicle | Hs | cellular component | 759 | 0.0 |
neuromuscular junction | Hs | cellular component | 1236 | 0.0 |
early endosome membrane | Hs | cellular component | 759 | 0.0 |
apolipoprotein binding | Hs | molecular function | 1236 | 0.0 |
identical protein binding | Hs | molecular function | 759 | 0.0 |
protein homodimerization activity | Hs | molecular function | 1236 | 0.0 |
Wnt-activated receptor activity | Hs | molecular function | 1236 | 0.0 |
neuronal cell body | Hs | cellular component | 1236 | 0.0 |
receptor complex | Hs | cellular component | 1236 | 0.0 |
membrane raft | Hs | cellular component | 759 | 0.0 |
synapse | Hs | cellular component | 759 | 0.0 |
coreceptor activity involved in Wnt signaling pathway | Hs | molecular function | 759 | 0.0 |
synaptic membrane | Hs | cellular component | 1236 | 0.0 |
scaffold protein binding | Hs | molecular function | 1236 | 0.0 |
coreceptor activity involved in canonical Wnt signaling pathway | Hs | molecular function | 759 | 0.0 |
Wnt-Frizzled-LRP5/6 complex | Hs | cellular component | 759 | 0.0 |
Wnt signalosome | Hs | cellular component | 759 | 0.0 |
GO Term | Analysis | Type | e-value |
---|---|---|---|
calcium ion binding | SMART | molecular function | 3.7E-9 |
protein binding | PRINTS | molecular function | 4.3E-39 |
BMP signaling pathway | PANTHER | biological process | 0.0 |
animal organ development | PANTHER | biological process | 0.0 |
regulation of canonical Wnt signaling pathway | PANTHER | biological process | 0.0 |