IPR Term	Analysis	Definition
Pept_C14A	CDD	Peptidase C14A, caspase catalytic domain
Pept_C14_p20	ProSiteProfiles	Peptidase C14, p20 domain
Pept_C14A	SMART	Peptidase C14A, caspase catalytic domain
DEATH-like_dom_sf	SUPERFAMILY	Death-like domain superfamily
CARD	SMART	CARD domain
CARD	ProSiteProfiles	CARD domain
Caspase-like_dom_sf	SUPERFAMILY	Caspase-like domain superfamily
Caspase_2	PANTHER	Caspase-2
CARD	Pfam	CARD domain
Pept_C14A	PRINTS	Peptidase C14A, caspase catalytic domain
Caspase_his_AS	ProSitePatterns	Peptidase family C14A, His active site
Pept_C14_p10	ProSiteProfiles	Peptidase C14, caspase non-catalytic subunit p10

GO Term	Annotation Origin	Type
protein binding	Orthology	molecular function
nucleus	Orthology	cellular component
nucleoplasm	Blast	cellular component
cytoplasm	Orthology	cellular component
mitochondrion	Orthology	cellular component
cytosol	Orthology	cellular component
plasma membrane	Blast	cellular component
proteolysis	Orthology	biological process
apoptotic process	Orthology	biological process
cellular response to DNA damage stimulus	Orthology	biological process
brain development	Orthology	biological process
peptidase activity	Orthology	molecular function
membrane	Orthology	cellular component
hydrolase activity	Orthology	molecular function
enzyme binding	Orthology	molecular function
intracellular signal transduction	Orthology	biological process
identical protein binding	Orthology	molecular function
regulation of apoptotic process	Orthology	biological process
positive regulation of apoptotic process	Orthology	biological process
negative regulation of apoptotic process	Orthology	biological process
intracellular membrane-bounded organelle	Blast	cellular component
membrane raft	Blast	cellular component
animal organ development	Orthology	biological process
endopeptidase activity	Orthology	molecular function
positive regulation of hydrolase activity	Orthology	biological process
developmental process	Orthology	biological process
peptidase activity, acting on L-amino acid peptides	Orthology	molecular function
gene expression	Orthology	biological process
reproductive process	Orthology	biological process
cell development	Orthology	biological process
programmed cell death	Orthology	biological process
signal transduction	Orthology	biological process
cell surface receptor signaling pathway	Orthology	biological process
cell projection assembly	Orthology	biological process
positive regulation of signal transduction	Orthology	biological process
cell cycle	Blast	biological process
enzyme regulator activity	Blast	molecular function
protein kinase binding	Blast	molecular function
molecular transducer activity	Blast	molecular function
protein serine/threonine kinase activity	Blast	molecular function
receptor binding	Blast	molecular function
enzyme activator activity	Blast	molecular function
plasma membrane part	Blast	cellular component
macromolecular complex	Blast	cellular component

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type
neural retina development	Hs	biological process
cysteine-type endopeptidase activity	Hs	molecular function
protein binding	Hs	molecular function
nucleus	Hs	cellular component
cytoplasm	Hs	cellular component
mitochondrion	Hs	cellular component
cytosol	Hs	cellular component
proteolysis	Hs	biological process
apoptotic process	Hs	biological process
activation of cysteine-type endopeptidase activity involved in apoptotic process	Hs	biological process
brain development	Hs	biological process
aging	Hs	biological process
peptidase activity	Hs	molecular function
cysteine-type peptidase activity	Hs	molecular function
intrinsic apoptotic signaling pathway in response to DNA damage	Hs	biological process
membrane	Hs	cellular component
protein processing	Hs	biological process
hydrolase activity	Hs	molecular function
enzyme binding	Hs	molecular function
protein domain specific binding	Hs	molecular function
ectopic germ cell programmed cell death	Hs	biological process
identical protein binding	Hs	molecular function
regulation of apoptotic process	Hs	biological process
positive regulation of apoptotic process	Hs	biological process
negative regulation of apoptotic process	Hs	biological process
positive regulation of neuron apoptotic process	Hs	biological process
cellular response to mechanical stimulus	Hs	biological process
cysteine-type endopeptidase activity involved in apoptotic process	Hs	molecular function
apoptotic signaling pathway	Hs	biological process
extrinsic apoptotic signaling pathway in absence of ligand	Hs	biological process
execution phase of apoptosis	Hs	biological process
cysteine-type endopeptidase activity involved in execution phase of apoptosis	Hs	molecular function
positive regulation of apoptotic signaling pathway	Hs	biological process

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type	Score	E-value
protease binding	Hs	molecular function	137	7.97e-37
aspartic-type endopeptidase activity	Hs	molecular function	137	7.97e-37
cysteine-type endopeptidase activity	Hs	molecular function	238	2.26e-72
cyclin-dependent protein serine/threonine kinase inhibitor activity	Hs	molecular function	137	7.97e-37
death receptor binding	Hs	molecular function	137	7.97e-37
protein binding	Hs	molecular function	238	2.26e-72
nucleus	Hs	cellular component	238	2.26e-72
nucleoplasm	Hs	cellular component	137	7.97e-37
cytoplasm	Hs	cellular component	238	2.26e-72
mitochondrion	Hs	cellular component	238	2.26e-72
cytosol	Hs	cellular component	238	2.26e-72
plasma membrane	Hs	cellular component	137	7.97e-37
peptidase activity	Hs	molecular function	238	2.26e-72
cysteine-type peptidase activity	Hs	molecular function	238	2.26e-72
cysteine-type endopeptidase activator activity involved in apoptotic process	Hs	molecular function	137	7.97e-37
phospholipase A2 activator activity	Hs	molecular function	137	7.97e-37
membrane	Hs	cellular component	238	2.26e-72
hydrolase activity	Hs	molecular function	238	2.26e-72
enzyme binding	Hs	molecular function	238	2.26e-72
protein domain specific binding	Hs	molecular function	238	2.26e-72
death-inducing signaling complex	Hs	cellular component	137	7.97e-37
identical protein binding	Hs	molecular function	238	2.26e-72
intracellular membrane-bounded organelle	Hs	cellular component	137	8.34e-36
membrane raft	Hs	cellular component	137	7.97e-37
cysteine-type endopeptidase activity involved in apoptotic process	Hs	molecular function	238	2.26e-72
cysteine-type endopeptidase activity involved in execution phase of apoptosis	Hs	molecular function	238	2.26e-72

GO Term	Analysis	Type	e-value
cysteine-type endopeptidase activity	PANTHER	molecular function	1.6E-98
proteolysis	ProSiteProfiles	biological process	35.336
cysteine-type peptidase activity	CDD	molecular function	7.99593E-73
regulation of apoptotic process	SMART	biological process	9.5E-17
cysteine-type endopeptidase activity involved in execution phase of apoptosis	PANTHER	molecular function	1.6E-98