Name

Ci-fkh -2.6Kb/Xotch

Targeted Gene

(NOTCH1; NOTCH2; NOTCH3)

Family

Sequence-based

Type

overexpression_construct

Supplier

n/a

Comment

Constitutively actived Xotch receptor (achieved by deleting most of the extracellular sequences including the EGF repeats) with a signal sequence from N-Caderin placed at 5 positions of the modified Xotch coding sequence. This construct were placed under the control of the Ciona forkhead (Ci-fkh) promoter region which mediate expression in notochord, endoderm and CNS

Regulation

Gain of function

Publication

Corbo et al. (1998). Suppressor of hairless activates brachyury expression in the Ciona embryo. Dev. Biol. 203(2):358-68