Name

Dorsomorphin

Targeted Gene

(SMAD1; SMAD5; SMAD9)

Targeted Gene Group

(SMAD1; SMAD5; SMAD9)

Family

Sequence-based

Type

inhibitor

Supplier

Wako

Comment

Dorsomorphin is an inhibitor of BMP signaling. Dorsomorphin treatment inhibits phosphorylation of Smad1/5.

Regulation

Loss of function

Publication

Ohta et al. (2013). Multiple signaling pathways coordinate to induce a threshold response in a chordate embryo. PLoS Genet. 9(10):e1003818

Fiuza et al. (2020). A Nodal/Eph signalling relay drives the transition from apical constriction to apico-basal shortening in ascidian endoderm invagination. Development 147(15):