Name

FGF8/17/18>CaEph3 (Stolfi 2011)

Targeted Gene

(EPHA4; EPHA7; EPHB2)

Family

Sequence-based

Type

overexpression_construct

Supplier

Comment

FGF8/17/18 cis-regulatory sequence drives a constitutively active form of Eph3 (KH.C7.568). Constitutively active Eph3 (caEph3) was made by fusing the C-terminal transmembrane and intracellular domains (aa 512-1027) of Eph3 to the self dimerizing N-terminus (aa 1-391) of Drosophila Torso receptor tyrosine kinase (Sprenger and Nusslein-Volhard, 1992).

Regulation

Gain of function

Publication

Stolfi et al. (2011). Neural tube patterning by Ephrin, FGF and Notch signaling relays. Development 138(24):5429-39